Definition of cyclophosphamide - National Cancer Institute Drug Dictionary

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cyclophosphamide

A synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic and immunosuppressive activities. In the liver, cyclophosphamide is converted to the active metabolites aldophosphamide and phosphoramide mustard, which bind to DNA, thereby inhibiting DNA replication and initiating cell death. Check for or using this agent. ()

Synonyms:		Ciclofosfamida Ciclofosfamide Claphene CP monohydrate CPM Cyclophospham Cyclophosphamid monohydrate Cyclophosphamidum Cyclophosphan Cyclophosphanum Cytophosphane Mitoxan Syklofosfamid Zytoxan

US brand names:		Clafen Cytoxan Neosar

Foreign brand names:		Carloxan Cicloxal Cycloblastin Cycloblastine CYCLO-cell Cyclostin Cyclostine Cytophosphan Endoxan Endoxana Enduxan Fosfaseron Genoxal Ledoxina Procytox Sendoxan

Abbreviation:		CTX

Code names:		Asta B 518 B-518 WR-138719

Chemical structure names:		1-bis(2-chloroethyl)-amino-1-oxo-2-aza-5-oxaphosphoridin monohydrate 2-[bis(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide monohydrate 2-[bis(b-chloroethyl)amino]-1-oxa-3-aza-2-phosphacyclohexane-2-oxide monohydrate 2-[di(chloroethyl)amino]-1-oxa-3-aza-2-phosphacyclohexane 2-oxide monohydrate 2H-1,3,2-oxazaphosphorin-2-amine, N,N-is(2-chloroethyl)tetrahydro-,2-oxide bis(2-chloroethyl)phosphamide cyclic propanolamide ester monohydrate bis(2-chloroethyl)phosphoramide cyclic propanolamide ester monohydrate N,N-bis(2-chloroethyl)-N'-(3-hydroxypropyl)phosphorodiamidic acid intramolecular ester monohydrate N,N-bis(2-chloroethyl)-N',O-propylenephosphoric acid ester diamide monohydrate N,N-bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-Oxide N,N-bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide monohydrate N,N-bis(b-chloroethyl)-N',O-trimethylenephosphoric acid ester diamide monohydrate N,N-bis(beta-chloroethyl)-N',O-propylenephosphoric acid ester diamide monohydrate N,N-bis(beta-chloroethyl)-N',O-trimethylenephosphoric acid ester diamide monohydrate

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