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oral JAK inhibitor INCB18424 An orally bioavailable Janus-associated kinase (JAK) inhibitor with potential antineoplastic and immunomodulating activities. Oral JAK inhibitor INCB18424 specifically binds to and inhibits protein tyrosine kinases JAK 1 and 2, which may lead to a reduction in inflammation and an inhibition of cellular proliferation. The JAK-STAT (signal transducer and activator of transcription) pathway plays a key role in the signaling of many cytokines and growth factors and is involved in cellular proliferation, growth, hematopoiesis, and the immune response; JAK kinases may be upregulated in inflammatory diseases, myeloproliferative disorders, and various malignancies. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
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Synonym: | ![](https://webarchive.library.unt.edu/eot2008/20090509222048im_/http://www.cancer.gov/images/spacer.gif) | oral Janus-associated kinase inhibitor INCB18424 | | ![](https://webarchive.library.unt.edu/eot2008/20090509222048im_/http://www.cancer.gov/images/spacer.gif) | Code name: | ![](https://webarchive.library.unt.edu/eot2008/20090509222048im_/http://www.cancer.gov/images/spacer.gif) | INCB18424 | | ![](https://webarchive.library.unt.edu/eot2008/20090509222048im_/http://www.cancer.gov/images/spacer.gif) |
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