Alternate Title
Basic Trial Information
Objectives
Entry Criteria
Expected Enrollment
Outline
Published Results
Trial Contact Information
Registry Information

Alternate Title

Temozolomide and O6-benzylguanine in Treating Patients With Newly Diagnosed, Recurrent, or Progressive Anaplastic Glioma

Basic Trial Information

Phase	Type	Status	Age	Sponsor	Protocol IDs
Phase I	Treatment	Closed	18 and over	NCI	DUMC-1388-02-8R2 DUMC-1388-00-8, NCI-490, DUMC-1388-01-8R1, NCT00006474, 490

Objectives

1. Determine the dose of O6-benzylguanine (O6-BG) effective in producing complete suppression of tumor O6-alkylguanine-DNA alkyltransferase activity in patients with newly diagnosed (closed to accrual 12/19/2000) or recurrent or progressive cerebral anaplastic glioma.
2. Determine the maximum tolerated dose of temozolomide administered after O6-BG in these patients.
3. Determine the toxicity of this regimen in these patients.
4. Determine the anti-tumor response in patients treated with this regimen.

Entry Criteria

Disease Characteristics:

• Part I:
  • Histologically confirmed, newly diagnosed glioblastoma multiforme or anaplastic astrocytoma (closed to accrual 12/19/2000)



• Parts I and II:
  • Histologically confirmed astrocytic, oligodendroglial, or mixed glial tumor
    • Grade III or higher
    • Recurrent or progressive after radiotherapy



• Evaluable residual disease by contrast-enhanced MRI or CT scan

Prior/Concurrent Therapy:

Biologic therapy:

• At least 6 weeks since prior biologic therapy and recovered

Chemotherapy:

• At least 2 weeks since prior chemotherapy (including but not limited to topotecan) and recovered
  • Patients in trials with one of the following treatment combinations are allowed to enroll 6 weeks after receiving carmustine (BCNU):
    • BCNU on day 1
    • BCNU on day 1 and topotecan on days 1, 8, 15, 22, 29, and 36
    • BCNU on day 1 and irinotecan on days 1, 8, 15, and 22

Endocrine therapy:

• Patients on corticosteroids must be on a stable dose for at least 2 weeks before study
• At least 6 weeks since other prior endocrine therapy and recovered

Radiotherapy:

• See Disease Characteristics
• At least 6 weeks since prior radiotherapy and recovered

Surgery:

• Not specified

Patient Characteristics:

Age:

• 18 and over

Performance status:

• Karnofsky 60-100%

Life expectancy:

• Not specified

Hematopoietic:

• Granulocyte count at least 1,500/mm3
• Platelet count at least 100,000/mm3

Hepatic:

• SGOT no greater than 2.5 times upper limit of normal
• Bilirubin normal

Renal:

• Creatinine no greater than 1.5 mg/dL

  OR

• Creatinine clearance greater than 60 mL/min
• BUN no greater than 25 mg/dL

Other:

• Not pregnant or nursing
• Negative pregnancy test
• Fertile patients must use effective contraception during and for 2 months after study

Expected Enrollment

Approximately 20-30 patients (with 14 patients participating in Part II) will be accrued for this study.

Outline

This is a dose-escalation, multicenter study.

• Part I: Patients receive escalating doses of O6-benzylguanine (O6-BG) IV continuously for 49 hours until the dose that produces the target depletion of tumor O6-alkylguanine-DNA alkyltransferase (AGT) is determined. Patients undergo a craniotomy after completion of the O6-BG infusion. (closed to accrual 12/19/2000)



• Part II: After determination of the O6-BG dose in Part I, patients with recurrent malignant gliomas receive O6-BG IV continuously for 49 hours beginning on day 1. Patients also receive oral temozolomide on day 1. Treatment repeats every 28 days in the absence of disease progression or unacceptable toxicity.

  Cohorts of 3-6 patients receive escalating doses of temozolomide until the maximum tolerated dose (MTD) is determined. The MTD is defined as the dose at which no more than 1 of 6 patients experiences dose-limiting toxicity.

Quinn JA, Desjardins A, Weingart J, et al.: Phase I trial of temozolomide plus O6-benzylguanine for patients with recurrent or progressive malignant glioma. J Clin Oncol 23 (28): 7178-87, 2005.[PUBMED Abstract]

Trial Contact Information

Trial Lead Organizations

Duke Comprehensive Cancer Center

Henry Friedman, MD, Protocol chair		Ph: 919-684-5301 Email: fried003@mc.duke.edu

Registry Information
Official Title		Phase I Trial of Temodar Plus O6-Benzylguanine (O6-BG) (NSC 637037) in the Treatment of Patients with Newly Diagnosed (Part 1) or Recurrent/Progressive (Parts 1 and 2) Cerebral Anaplastic Gliomas
Trial Start Date		2001-03-02
Registered in ClinicalTrials.gov		NCT00006474
Date Submitted to PDQ		2000-09-26
Information Last Verified		2003-05-06
NCI Grant/Contract Number		P30-CA14236