Hans H Cheng
Avian Disease and Oncology Laboratory
Supervisory Research Geneticist
Phone: (517) 337-6758
Fax: (517) 337-6776
3606 E MOUNT HOPE ROAD
EAST LANSING, MI, 48823-5338
Groenen, M.A., Wahlberg, P., Foglio, M., Cheng, H.H., Megens, H.J., Crooijmans, R.P., Besnier, F., Lathrop, M., Muir, W.M., Wong, G.K., Gut, I., Andersson, L. 2009. A High-Density SNP-Based Linkage Map of the Chicken Genome Reveals Sequence Features Correlated With Recombination Rate. Genome Research. 19(3):510-519.
Muir, W.M., Wong, G., Zhang, Y., Wang, J., Groenen, M., Crooijmans, R., Megens, H., Zhang, H., Okimoto, R., Vereijken, A., Jungerius, A., Albers, G., Taylor Lawley, C., Delany, M.E., Maceachern, S.A., Cheng, H.H. 2008. Genome-wide assessment of worldwide chicken SNP genetic diversity indicates significant absence of rare alleles in commercial breeds. Proceedings of the National Academy of Sciences. 105(45):17312-17317.
Cheng, H., Niikura, M., Kim, T., Mao, W., MacLea, K., Hunt, H., Dodgson, J., Burnside, J., Morgan, R., Ouyang, M., Lamont, S., Dekkers, J., Fulton, J., Soller, M., Muir, W. 2008. Using integrative genomics to elucidate genetic resistance to Marek's disease in chicken. In: Pinard M-H, Gay, C., Pastoret, P-P, Dodet, B., editors. Integrative Genomics for Disease Resistance: Animal Genomics for Animal Health. Developments in Biologicals. Basel, Switzerland: Karger. p. 365-372.
Mao, W., Niikura, M., Silva, R.F., Cheng, H.H. 2008. Quantitative evaluation of viral fitness due to a single nucleotide polymorphism in the Marek's disease virus UL41 gene via an in vitro competition assay. Journal of Virological Methods. 148:125-131.
Zhang, H.M., Bacon, L.D., Heidari, M., Muir, W.M., Groenen, M.A.M., Zhang, Y., Wong, G.K.S., Fulton, J.E., O'Sullivan, N.P., Albers, G.A.A., Vereijken, A.L.J., Rattink, A.P., Okimoto, R., McKay, J.C., McLeod, S., Cheng, H.H. 2007. Genetic variation at the tumour virus B locus in commercial and laboratory chicken populations assessed by a medium-throughput or a high-throughput assay. Avian Pathology. p. 283-291.
Granevitze, Z., Blum, S., Cheng, H.H., Vignal, A., Morisson, M., Ben-Ari, G., David, L., Feldman, M.W., Weigend, S., Hillel, J. 2007. Female-specific DNA sequences in the chicken genome. Journal of Heredity. 98:238-242.
Zhang, H.M., Dunn, J.R., Witter, R.L., Heidari, M., Bacon, L.D., Cui, Y., Song, J., Cheng, H.H. 2007. Putative evidence that genes outside the MHC have a significant influence on efficacy of Marek's disease vaccine [abstract]. Plant and Animal Genome VX Conference Abstracts. Paper #107. p. 128.
Niikura, M., Kim, T., Hunt, H.D., Burnside, J., Morgan, R., Dodgson, J., Cheng, H.H. 2007. Marek's disease virus up-regulates major histocompatibility complex class II cell surface expression in infected cells. Virology. 359(1): 212-219.
Cheng, H.H., Hunt, H.D., Delany, M.E. 2006. Molecular characterization of MD tumors with respect to clonality, loss of heterozygosity, and MDV integration [abstract]. 4th International Workshop on Molecular Pathogenesis of Marek's Disease Virus. p. 6.
MacLea, K.S., Cheng, H.H. 2006. Purification of MDV-chicken protein complexes using molecularly cloned and tagged MDV-BACS [abstract]. 4th International Workshop on Molecular Pathogenesis of Marek's Disease Virus. p. 38.
Kim, T., Hunt, H.D., Cheng, H.H. 2006. Characterization of MDV LORF4 and R-LORF10 in MDV-infected cells and chicken [abstract]. 4th International Workshop on Molecular Pathogenesis of Marek's Disease Virus. p. 38.
Backstrom, N., Brandstrom, M., Gustafsson, L., Qvarnstrom, A., Cheng, H.H., Ellegren, H. 2006. Genetic mapping in a natural population of collared flycatchers (Ficedula albicollis): conserved synteny but gene order rearrangements on the avian Z chromosome. Genetics. Paper no. 106.058917(1). Available: http://www.genetics.org/cgi/content/abstract/genetics.
Hunt, H.D., Kim, T., Niikura, M., Cheng, H.H., Parcells, M., Ewald, S., Osterrieder, K. 2006. Marek's disease virus immune escape mechanisms. American Association of Avian Pathologists. In: American Association of Avian Pathologists Symposium Program. Impact of Subclinical Immunosuppression on Poultry Production, July 2006, Honolulu, Hawaii. p. 61-66.
Cheng, H.H., Kim, T.J., Niikura, M., Hunt, H.D. 2006. Using recombinant viruses to query the functional significance of the protein-protein interactions between chicken MHC class II and Marek's disease virus LORF4 and R-LORF10 [abstract]. International Symposium on Animal Functional Genomics. p. 8.
Atzmon, G., Ronin, Y.I., Korol, A., Yonash, N., Cheng, H.H., Hillel, J. 2006. QTLs associated with growth traits and abdominal fat weight and their interactions with gender and hatch in commercial meat-type chickens. Animal Genetics. 37(4):352-358.
Niikura, M., Dodgson, J., Cheng, H.H. 2006. Direct evidence of host genome acquisition by the alphaherpesvirus Marek's disease virus (MDV)[Abstract]. Keystone Symposia: Cell Biology of Virus Entry, Replication and Pathogenesis. p. 69
Niikura, M., Dodgson, J.B., Cheng, H.H. 2006. Stability of Marek's disease virus 132bp repeats during serial in vitro passages. Archives of Virology. 151:1431-1438.
Ben-Avraham, D., Blum, S., Granevitze, Z., Weigend, S., Cheng, H.H., Hillel, J. 2006. W-specific microsatellite loci detected by in silico analysis, map to chromosome Z of the chicken genome. Animal Genetics. 37:179-188.
Cheng, H.H., Zhang, H.M., Muir, W.M., Groenen, M.A., Wong, G.K. 2006. Preliminary results on the validation and application of 3,072 chicken SNPs by genotyping 2,576 commercial and experimental birds [abstract]. Plant and Animal Genome XIV. p. 143.
Niikura, M., Dodgson, J., Cheng, H.H. 2006. Direct evidence of host genome acquisition by the alphaherpesvirus Marek's disease virus. Archives of Virology. 151:537-549. Available online. DOI 10.1007/S00705-005-0633-7.
Zhang, H.M., Bacon, L.D., Cheng, H.H., Hunt, H.D. 2005. Development and validation of a PCR-RFLP assay to evaluate TVB haplotypes coding receptors for subgroup B and subgroup E avian leukosis viruses in White Leghorns. Avian Pathology. 34(4):324-331.
Cheng, H.H. 2005. Integrated genomic approaches to understanding resistance to Marek's disease. In: Proceedings of the 3rd International Symposium on Genetics of Animal Health, July 13-15, 2005, Ames, Iowa. p. 24-33.
Cheng, H.H., Niikura, M., Kim, T., MacLea, K.S., Hunt, H.D., Morgan, R., Burnside, J. 2005. Integrating genomic and immunological approaches to understand Marek's disease [abstract]. Keystone Symposia: Systems and Biology (X4), p. 101.
Wong, G., Liu, B., Andersson, L., Groenen, M., Hunt, H.D., Cheng, H.H. 2004. A genetic variation map for chicken with 2.8 million single nucleotide polymorphisms. Nature Magazine. 432:717-722.
Zhang, H.M., Hunt, H.D., Cheng, H.H., Dodgson, J.B., Romanov, M., Bacon, L.D. 2005. Identification and evaluation of SNPs at the 3' end of the tva gene segregating among ALSV resistance and susceptible lines of chickens [abstract]. Plant & Animal Genome XIII Conference. p. 197:123.
Wallis, J.W., Aerts, J., Groenen, M., Crooijmans, R., Layman, D., Graves, T.A., Scheer, D., Kremitzki, C., Fedele, M., Mudd, N., Cardenas, M., Higginbotham, J., Carter, J., McGrane, R., Gaige, T., Mead, K., Walker, J., Albracht, D., Davito, J., Yang, S., Leong, S., Chinwalla, A., Sekhon, M., Wylie, K., Dodgson, J., Romanov, M., Cheng, H.H., deJong, P., Osoegawa, K., Nefedov, M., Zhang, H., McPherson, J., Krzywinski, M., Schein, J., Hillier, L., Mardis, E., Wilson, R., Warren, W. 2004. A physical map of the chicken genome. Nature Magazine. 432:761-764.
Cheng, H.H., Niikura, M., Hunt, H.D. 2004. Identification of novel genes involved in resistance to Marek's disease [abstract]. International Marek's Disease Symposium Abstracts and Proceedings. Paper No. II-5.
Niikura, M., Dodgson, J., Cheng, H.H. 2004. Characterization and complete sequence of an infectious Marek's disease virus bacterial artificial chromosome clone generated from a virulent strain [abstract]. International Marek's Disease Symposium Abstracts and Proceedings. Paper No. P.17.
Cheng, H.H., Niikura, M., Hunt, H.D. 2004. Identification of novel genes involved in resistance to Marek's disease. International Marek's Disease Symposium Abstracts and Proceedings. Paper II.5.
Cheng, H.H., Niikura, M., Hunt, H.D. 2004. Identifying Marek's disease resistance gene and pathways through integrative genomic approaches. World Veterinary Poultry Association Congress Proceedings, June 8-13, 2004, Istanbul, Turkey. 2004 CD ROM.
Zhang, H.M., Cheng, H.H. 2004. SNP identification and genetic mapping of chicken ephrin type-B receptor 2 gene to linkage group E54. Animal Genetics. 35:162-163.
Niikura, M., Liu, H.C., Dodgson, J.B., Cheng, H.H. 2004. A comprehensive screen for chicken proteins that interact with proteins unique to virulent strains of Marek's disease virus. Poultry Science. 83:1117-1123.
Cheng, H.H., Liu, H., Niikura, M. 2004. A comprehensive screen for Marek's disease virus-chicken protein interactions to identify disease resistance genes. Plant and Animal Genome Conference Proceedings. p. 293.
Liu, H., Niikura, M., Fulton, J.E., Cheng, H.H. 2003. Identification of chicken lymphocyte antigen 6 complex, locus e (LY6E, alias SCA2) as a putative Marek's disease resistance gene via a virus-host protein interaction screen. Cytogenetics and Genome Research. 102:304-308. (DOI:10.1159/000075767).
Zhang, H.M., Hunt, H.D., Cheng, H.H., Bacon, L.D. 2003. A PCR based SNP analysis of the chicken TVB receptor gene [abstract]. Poultry Science. 82(1):49.
Zhu, J.J., Lillehoj, H.S., Allen, P.C., Van Tassell, C.P., Sonstegard, T.S., Cheng, H.H., Pollock, D., Sadjadi, M., Min, W., Emara, M.G. 2003. Mapping quantitative trait locus associated with resistance to avian coccidiosis and growth. Poultry Science 82:9-16.
Cheng, H.H., Liu, H. 2003. Identifying disease resistance genes and pathways through host-pathogen protein interactions [abstract]. Plant and Animal Genome Conference Proceedings. p. 40.
Liu, H., Niikura, M., Cheng, H.H. 2003. Screening for candidate genes that confer marek's disease resistance by combining two-hybrid assays and QTL linkage analysis [abstract]. Plant and Animal Genome Conference Proceedings. p. 108.
Liu, H., Cheng, H.H. 2002. Integrating molecular approaches with QTL to identify positional candidate genes. World Congress of Genetics Applied in Livestock Production. p. 40-49.