Basic Trial Information
Trial Description
     Summary
     Further Trial Information
     Eligibility Criteria
Trial Contact Information

Basic Trial Information

Phase	Type	Status	Age	Sponsor	Protocol IDs
Phase II	Treatment	Active	18 to 65	Other	CHUBX 2007/11 NCT00607854

Trial Description

Summary

The purpose of this study is to evaluate the safety and efficacy of Zevalin® in a Reduced Intensity Conditioning regimen followed by allogenic stem cell support in patients with aggressive lymphomas who are responsive to a salvage chemotherapy regimen.

Further Study Information

The benefit of Zevalin® in the setting of autologous stem cell transplantation has been largely reported. The addition of Zevalin® to a fludarabine-based Reduced Intensity Conditioning regimen has been already evaluated in the setting of allo-SCT and the results reported so far seem to be promising without an overwhelming toxicity neither a delayed hematologic recovery. The assumption that the addition of Zevalin® to the conditioning regimen might improve lymphoma control and the demonstration that nucleoside analogs such as fludarabine synergize optimally with RIT led us to conduct this trial using the following preparative regimen: rituximab 250 mg/m² on days -21 and -14, Zevalin® 0,4 mCi/Kg body weight on day -14, fludarabine 30 mg/m² intravenously from days -6 to -2, Busulfan orally (4 mg/Kg body weight) or intravenously (0,8 mg/Kg body weight) on days -5 and -4 and ATG (Thymoglobulin®) 2,5 mg/Kg body weight intravenously on day -1. Cyclosporine A is administered at 2 or 3 mg/Kg body weight from day -1 to day 28 than followed by a dose reduction.

The purpose of this study is to evaluate the safety and efficacy of Zevalin® in a Reduced Intensity Conditioning regimen followed by allogenic stem cell support in patients with aggressive lymphomas who are responsive to a salvage chemotherapy regimen

Patients are followed from the beginning of the RIC regimen until day 365 for primary and secondary objectives of the study than on a regular basis depending on the practice of each centre. The evaluation includes physical examination (performance status, hematologic assessment, acute and chronic GVH disease), biologic tests (blood screening for blood count, renal and hepatic function, B and T-cell recovery, chimerism analysis, response assessment) and complementary examinations (marrow biopsies, tomography scan, positron emission tomography, …).

Eligibility Criteria

Inclusion Criteria:

• Age ≥ 18 and ≤ 65

• CD20 positive diffuse large B-cell lymphoma in relapse after two prior regimens or after one regimen including autologous stem cell transplantation

• CD20 positive mantle-cell lymphoma in relapse after two prior regimens or after one regimen including autologous stem cell transplantation

• HLA-matched related or unrelated donor without contra-indication for stem cell mobilization

• ECOG (Eastern Cooperative Oncology Group) < 2

• Having or not received previously rituximab

• With a chemosensitive relapse NHL (at least partial response > 50% as defined with cheson criteria (See appendix 5)

• Eligible for an allogenic transplant

• With a signed informed consent (obtained on the screening day at the latest and before any investigation)

• Patient affiliated to or beneficiary of the National Health Service

Exclusion Criteria:

• Patient allografted previously

• History of cancer

• Patient with HIV or HCV positive serology and requiring treatment

• Childbearing or child breastfeading women

• Women who are pregnant or nursing, or man, in the absence of effective contraception during treatment and up to 12 months after stopping treatment

• Any contraindication to allogenic stem cell transplantation:

• Cardiac insufficiency (ejection fraction < 50% by echocardiography)

• Respiratory insufficiency defined as DLCO below 50% of the theoretical value

• Renal failure defined as creatinin clearance < 30 ml/mn

• Hepatic failure defined as a 2-fold increase of bilirubin or transaminases except if due to the lymphoma

• Known hypersensitivity to murine antibodies and other proteins, the active ingredients or any of the ingredients of the products under review

• Patient under the protection of justice

Trial Contact Information

Trial Lead Organizations/Sponsors

CHU de Bordeaux - Hopital Pellegrin

Krimo BOUABDALLAH, MD

Principal Investigator

Geneviève CHENE, Pr

Study Chair

Krimo BOUABDALLAH, MD		Ph: +33 (0) 5 57 65 65 11
		Email: krimo.bouabdallah@chu-bordeaux.fr

France
	Bordeaux - Pessac
		Stephane VIGOUROUX	Sub-Investigator
		Reza TABRIZI	Sub-Investigator
		Noel MILPIED	Sub-Investigator
	Hopital Haut Leveque
		Krimo BOUABDALLAH, MD	Principal Investigator

Link to the current ClinicalTrials.gov record.
NLM Identifer NCT00607854
Information obtained from ClinicalTrials.gov on March 18, 2009