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biricodar dicitrate The dicitrate salt of a synthetic pipecolinate derivative with potential chemosensitizing activity. Biricodar binds directly to the plasma membrane drug-efflux pumps P-glycoprotein (Pgp) and multidrug resistance protein 1 (MRP-1) and inhibits their activities, which may result in increased intracellular accumulation and retention of cytotoxic agents. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonym: | | biricodar | | | US brand name: | | Incel | | | Code name: | | VX-710 | | |
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