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Dose-Finding of Lenalidomide as Maintenance in Multiple Myeloma
Basic Trial Information Trial Description Summary Eligibility Criteria Trial Contact Information
Basic Trial Information
Phase | Type | Status | Age | Protocol IDs |
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Phase II, Phase I | Treatment | Active | Over 18 | Revlimid as maintenance in MM NCT00778752 |
Trial Description
Summary This study is a Phase I (non-randomized) study evaluating three dose-levels of Lenalidomide in patients after allogeneic stem cell transplantation, accomplished in two institutions (University Medical Center Hamburg-Eppendorf/ University Medical Center Heidelberg). Eligibility Criteria Inclusion Criteria: - Understand and voluntarily sign informed consent form
- Age > 18 years at the time of signing the informed consent form
- Able to adhere to the study visit schedule and other protocol requirements
- Multiple myeloma patients who received allogeneic stem cell transplantation (100 to 180 days ago)
- No active acute GvHD (grade II - IV)
- No active infectious complications
- ECOG performance status of < 2 at study entry
- Laboratory test results within these ranges:
- Absolute WBC count > 3.0 x 10^9/l
- Platelet count > 80 x 10^9/l
- Serum creatinine < 1.5 mg/dl
- Total bilirubin < 1,5 mg/dl
- AST (SGOT) and ALT (SGPT) < 3 x ULN
- Females of childbearing potential must agree to use two reliable forms of contraception simultaneously or to practice complete abstinence from heterosexual intercourse for at least 28 days before starting study drug, while participating in the study and at least 28 days after discontinuation from the study.
- male subjects must agree to use a latex condom during sexual contact with females of childbearing potential while participating in the study and for at least 28 days after discontinuation of study drug
- disease free of prior malignancies for > 5 years with exception of currently treated basal cell, squamous cell carcinoma of the skin, or carcinoma "in situ" of the cervix or breast
Exclusion Criteria: - Any serious medical condition, laboratory abnormality, or psychiatric illness that would prevent the subject from signing the informed consent form
- pregnant or breast feeding females
- use of any other experimental drug or therapy within 28 days of baseline
- known hypersensitivity to thalidomide
- concurrent use of other anti-cancer agents or treatments
- known positive for HIV of infectious hepatitis, type A, B, or C
Trial Contact Information
Trial Lead Organizations/Sponsors University Medical Center Hamburg - Eppendorf Nicolaus Kroeger, Prof. Dr. | | Principal Investigator |
Trial Sites
Link to the current ClinicalTrials.gov record.
NLM Identifer NCT00778752 Information obtained from ClinicalTrials.gov on April 10, 2009 Note: Information about this trial is from the ClinicalTrials.gov database. The versions designated for health professionals and patients contain
the same text. Minor
changes may be made to the ClinicalTrials.gov record to standardize the names of study sponsors, sites, and
contacts. Cancer.gov only lists sites that are recruiting patients for active trials, whereas ClinicalTrials.gov lists all sites for all trials. Questions and comments regarding the presented information should
be directed to ClinicalTrials.gov. Back to Top |
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