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KW 2189 A semisynthetic water-soluble derivative of the antineoplastic antibiotic duocarmycin B2. Activated by carboxyl esterase, KW 2189 alkylates DNA by binding to adenine-thymine (A-T)-rich sequences in the minor groove of DNA, thereby inhibiting DNA replication and inducing apoptosis. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
![](https://webarchive.library.unt.edu/eot2008/20090509191941im_/http://www.cancer.gov/images/spacer.gif)
Synonym: | ![](https://webarchive.library.unt.edu/eot2008/20090509191941im_/http://www.cancer.gov/images/spacer.gif) | Duocamycin B2 Analog | | ![](https://webarchive.library.unt.edu/eot2008/20090509191941im_/http://www.cancer.gov/images/spacer.gif) | Code name: | ![](https://webarchive.library.unt.edu/eot2008/20090509191941im_/http://www.cancer.gov/images/spacer.gif) | KW-2189 | | ![](https://webarchive.library.unt.edu/eot2008/20090509191941im_/http://www.cancer.gov/images/spacer.gif) | Chemical structure name: | ![](https://webarchive.library.unt.edu/eot2008/20090509191941im_/http://www.cancer.gov/images/spacer.gif) | Benzo(1,2-b:4,3-b')dipyrrole-1-carboxylic Acid, 8-(bromomethyl)-3,6,7,8-tetrahydro-2-methy-4-(((4-methyl-1-piperazinyl)carbonyl)oxy)-6-((5,6,7,-trimethoxy-1H-indol-2-yl)carbonyl)-, Methyl Ester (S) | | ![](https://webarchive.library.unt.edu/eot2008/20090509191941im_/http://www.cancer.gov/images/spacer.gif) |
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