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safingol A saturated derivative of sphingosine. As an inhibitor of protein kinase C (PKC), safingol competitively binds to the regulatory phorbol-binding domain of PKC, a kinase involved in tumorigenesis. This agent has been shown to act synergistically with other chemotherapeutic agents and may potentiate chemotherapy drug-induced apoptosis in vitro and in vivo. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
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Synonym: | ![](https://webarchive.library.unt.edu/eot2008/20090509174524im_/http://www.cancer.gov/images/spacer.gif) | sphinganine | | ![](https://webarchive.library.unt.edu/eot2008/20090509174524im_/http://www.cancer.gov/images/spacer.gif) | US brand name: | ![](https://webarchive.library.unt.edu/eot2008/20090509174524im_/http://www.cancer.gov/images/spacer.gif) | Kynacyte | | ![](https://webarchive.library.unt.edu/eot2008/20090509174524im_/http://www.cancer.gov/images/spacer.gif) | Chemical structure names: | ![](https://webarchive.library.unt.edu/eot2008/20090509174524im_/http://www.cancer.gov/images/spacer.gif) | - 2-amino-1,3-dihydroxyoctadecane
- L-threo-dihydrosphingosine
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