 |
|
CNGRC peptide-TNF alpha conjugate
A cytokine-peptide conjugate composed of the cytokine tumor necrosis factor alpha (TNF-alpha) chemically linked to the peptide CNGRC. The peptide moiety CNGRC, a ligand for the membrane-bound metalloprotease CD13, binds to endothelial cells of the angiogenic vasculature that express CD13 (also known as aminopeptidase N); subsequently, the TNF-alpha moiety induces apoptosis in endothelial cells expressing CD13, thereby inhibiting tumor-associated angiogenesis. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
| Synonyms: | | CNGRC peptide-tumor necrosis factor alpha conjugate
tumor vasculature-targeted tumor necrosis factor alpha | | | | Abbreviations: | | NGR-hTNF
NGR-TNF | | |
|
|
