Projects

BOVINE VIRAL DISEASE PATHOGENESIS AND IMMUNOLOGY Appropriated (D)   Accession Number: 415093

Publications

Adenovirus-Mediated Expression of Interferon-Alpha Delays Viral Replication and Reduces Disease Signs in Swine Challenged with Porcine Reproductive and Respiratory Syndrome Virus - (Peer Reviewed Journal) - (24-Jan-09)

Minimum intravenous infectious dose of ovine progressive pneumonia virus (OPPV) - (Peer Reviewed Journal) - (19-Jan-09)

Serologic and hexon phylogenetic analysis of ruminant adenoviruses - (Peer Reviewed Journal)

Lehmkuhl, H.D. 2008. Serologic and hexon phylogenetic analysis of ruminant adenoviruses. Archives of Virology. 153(5):891-897.

EVALUATION OF THE PATHOGENIC POTENTIAL OF CERVID ADENOVIRUS IN CALVES - (Peer Reviewed Journal)

Woods, L.W., Lehmkuhl, H.D., Parker, J.C., Manzer, M. 2008. Evaluation of the Pathogenic Potential of Cervid Adenovirus in Calves. Journal of Veterinary Diagnostic Investigation. 20(1):33-37.

Pretreatment with recombinant human vascular endothelial growth factor reduces virus replication and inflammation in a peri-natal lamb model of RSV infection - (Abstract)

Meyerholz, D.K., Gallup, J.M., Lazic, T., Macedo, M.M., Lehmkuhl, H.D., Ackermann, M.R. 2006. Pretreatment with recombinant human vascular endothelial growth factor reduces virus replication and inflammation in a peri-natal lamb model of RSV infection [abstract]. Interscience Conference on Antimicrobial Agents & Chemotherapy Proceedings. September 30, 2006, San Francisco, California. p. 461.

Viruses as Predisposing Factors to Bacterial Pneumonia - (Abstract)

Lehmkuhl, H.D., Briggs, R.E., Sacco, R.E., Tatum, F.M. 2007. Viruses as Predisposing Factors to Bacterial Pneumonia [abstract]. Respiratory Disease in Mountain Sheep: Knowledge Gaps and Future Research. p. 154.

Pretreatment with recombinant human vascular endothelial growth factor virus replication and inflammation in a perinatal lamb model of RSV infection - (Peer Reviewed Journal)

Meyerholz, D.K., Gallup, J.M., Tatjana, L., De Macedo, M.M., Lehmkuhl, H.D., Ackermann, M.R. 2006. Pretreatment with Recombinant Human Vascular Endothelial Growth Factor Virus Replication and Inflammation in a Perinatal Lamb Model of RSV Infection. Viral Immunology. 20(1):188-196.

NEONATAL OVINE PULMONARY DENDRITIC CELLS SUPPORT BRSV REPLICATION WITH ENHANCED IL-4 AND IL-10 GENE TRANSCRIPTS - (Peer Reviewed Journal)

Fach, S.J., Meyerholz, D.K., Gallup, J.M., Ackermann, M.R., Lehmkuhl, H.D., Sacco, R.E. 2007. Neonatal Ovine Pulmonary Dendritic Cells Support BRSV Replication with Enhanced IL-4 and IL-10 Gene Transcripts. Viral Immunology. 20(1):119-130.

Presence of interferon-alpha delays viral replication and reduces disease signs in pigs challenged with porcine reproductive and respiratory syndrome virus - (Abstract)

Brockmeier, S.L., Lager, K.M., Grubman, M.J., Brough, D., Ettyreddy, D., Sacco, R.E., Gauger, P.C., Lehmkuhl, H.D. 2006. Presence of interferon-alpha delays viral replication and reduces disease signs in pigs challenged with porcine reproductive and respiratory syndrome virus. Proceedings of the 87th Conference of Research Workers in Animal Diseases, December 3-5, 2006. Chicago, Illinois. p.124.

Presence of interferon-alpha delays viral replication and reduces disease signs in pigs challenged with porcine reproductive and respiratory syndrome virus - (Abstract)

Brockmeier, S.L., Lager, K.M., Grubman, M.J., Brough, D., Ettyreddy, D., Sacco, R.E., Gauger, P.C., Lehmkuhl, H.D. 2006. Presence of interferon-alpha delays viral replication and reduces disease signs in pigs challenged with porcine reproductive and respiratory syndrome virus. Proceeding of the International PRRS Symposium, December 1-2, 2006, Chicago, Illinois. p. 27.

Pretreatment with recombinant human vascular endothelial growth factor (VEGF) reduces virus replication and inflammation in a perinatal lamb model of RSV infection - (Abstract)

Meyerholz, D.K., Gallup, J.M., Lazic, T., Macedo, M.M., Lehmkuhl, H.D., Ackermann, M.R. 2006. Pretreatment with recombinant human vascular endothelial growth factor (VEGF) reduces virus replication and inflammation in a perinatal lamb model of RSV infection [abstract]. Veterinary Comparative Respiratory Meeting, October 9-10, 2006, Jena, Germany. p.56.

Differential Expression of Ovine Innate Immune Genes by Preterm and Neonatal Lung Epithelia Infected with Respiratory Syncytial Virus - (Abstract)

Kawashima, K., Meyerholz, D.K., Gallup, J.M., Grubor, B., Lazic, T., Lehmkuhl, H.D., Ackermann, M.R. Differential Expression of Ovine Innate Immune Genes by Preterm and Neonatal Lung Epithelia Infected with Respiratory Syncytial Virus [abstract]. Veterinary Comparative Respiratory Meeting, October 9-10, 2006, Jena, Germany. p. 1.

Differential Expression of Ovine Innate Immune Genes by Preterm and Neonatal Lung Epithelia Infected with Respiratory Syncytial Virus - (Peer Reviewed Journal)

Kawashima, K., Meyerholz, D.K., Gallup, J.M., Grubor, B., Lazic, T., Lehmkuhl, H.D., Ackermann, M.R. Differential Expression of Ovine Innate immune Genes by Preterm and Neonatal Lung Epithelia Infected with Respiratory Syncytial Virus. Viral Immunology. 19(2):316-323.

PULMONARY DENDRITIC CELLS ISOLATED FROM NEONATAL AND ADULT OVINE LUNG TISSUE - (Peer Reviewed Journal)

Fach, S.J., Brockmeier, S., Hobbs, L.A., Lehmkuhl, H.D., Sacco, R.E. 2006. Pulmonary dendritic cells isolated from neonatal and adult ovine lung tissue. Veterinary Immunology and Immunopathology. 112(3-4):171-82.

OVERVIEW OF RESEARCH AT THE NATIONAL ANIMAL DISEASE CENTER - (Abstract)

Lehmkuhl, H.D. 2005. Overview of Research at the National Animal Disease Center[abstract]. United States Japan Natural Resources Animal and Avian Health Panel. p. 4-5.

NOVEL CAPRINE ADENO-ASSOCIATED VIRUS (AAV) CAPSID (AAV-GO.1) IS CLOSELY RELATED TO THE PRIMATE AAV-5 AND HAS UNIQUE TROPISM AND NEUTRALIZATION PROPERTIES - (Peer Reviewed Journal)

Arbetman, A.E., Lochrie, M., Shangzhen, Z., Wellman, J., Scallan, C., Doroudchi, M.M., Lehmkuhl, H.D., Hobbs, L.A., Pierce, G.F., Colosi, P. 2005. Novel caprine adeno-associated virus (AAV) capsid (AAV-GO.1) is closely related to the primate AAV-5 and has unique tropism and neutralization properties. Journal of Virology. 79(24):15238-15245.

EVALUATION OF THE PATHOGENIC POTENTIAL OF DEER ADENOVIRUS INFECTION IN CALVES - (Abstract)

Woods, L., Lehmkuhl, H.D., Parker, J., Hobbs, L.A., Manzer, M. 2005. Evaluation of the pathogenic potential of deer adenovirus infection in calves [abstract]. American Association of Veterinary Laboratory Diagnosticians. p.30.

NEONATAL LAMB RESPIRATORY TRACT DENDRITIC CELLS AND THE EFFECTS OF RSV INFECTION - (Abstract)

Fach, S.J., Meyerholz, D.K., Gallup, J.M., Ackermann, M.R., Lehmkuhl, H.D., Sacco, R.E. 2005. Neonatal lamb respiratory tract dendritic cells and the effects of RSV infection [abstract]. Federation of American Societies for Experimental Biology Conference. 19:A403.

EFFECT OF BRSV INFECTION IN NEONATAL LAMBS ON RESPIRATORY TRACT DENDRITIC CELLS - (Abstract)

Fach, S.J., Meyerholz, D.K., Gallup, J.M., Ackermann, M.R., Lehmkuhl, H.D., Sacco, R.E. 2004. Effect of BRSV infection in neonatal lambs on respiratory tract dendritic cells [abstract]. Autumn Immunology Conference. p. 52.

INNATE IMMUNITY OF RESPIRATORY EPITHELIA: EFFECTS OF PRETERM BIRTH AND RESPIRATORY SYNCYTIAL VIRUS INFECTION - (Abstract)

Ackermann, M.R., Meyerholz, D.K., Grubor, B., Lehmkuhl, H.D., Sacco, R.E., Gallup, J.M., Derscheid, R., Lazic, T., Fach, S., Kawashima, K. 2004. Innate immunity of respiratory epithelia: effects of preterm birth and respiratory syncytial virus infection [abstract]. Conference of Research Workers in Animal Diseases. p. 136.

ADENOVIRUS INFECTION IN SHEEP AND GOATS - (Abstract)

Lehmkuhl, H.D. 2004. Adenovirus infection in sheep and goats. Proceedings of the United States Animal Health Association. Available: http://www.usaha.org/committees/sg/sg.shtml.

INCREASED SEVERITY OF BOVINE RESPIRATORY SYNCYTIAL VIRUS INFECTION IN PRETERM LAMBS - (Abstract)

Meyerholz, D.K., Grubor, B., Fach, S.J., Sacco, R.E., Lehmkuhl, H.D., Gallup, J.M., Ackermann, M.R. 2004. Increased severity of bovine respiratory syncytial virus infection in preterm lambs [abstract]. Bi-Annual All-Iowa Virology Symposium. Paper No. 12.

REDUCED CLEARANCE OF RESPIRATORY SYNCYTIAL VIRUS IN A PRETERM LAMB MODEL - (Peer Reviewed Journal)

Meyerholz, D.K., Grubor, B., Fach, S.J., Sacco, R.E., Lehmkuhl, H.D., Gallup, J.M., Ackermann, M.R. 2004. Reduced clearance of respiratory syncytial virus in a preterm lamb model. Microbes and Infection. 6(14):1312-1319.

ADENOVIRIDAE - (Book/Chapter)

Benko, M., Harrach, B., Both, G.W., Russell, W.C., Adair, B.M., Adam, E., deJong, J.C., Hess, M., Johnson, M., Kajon, A., Kidd, A.H., Lehmkuhl, H.D., Li, Q., Mautner, V., Pring-Akerblom, P., Wadell, G. 2005. Adenoviridae. In: Fauquet, C.M., Mayo, M.A., Maniloff, J., Desselberger, U., Ball, L.A., editors. Virus Taxonomy. Eighth Report of the International Committee on the Taxonomy of Viruses. San Diego, California: Elsevier Academic Press. p. 213-228.

ADENOVIRUS-MEDIATED GENE THERAPY ENHANCES PARAINFLUENZA VIRUS 3 INFECTION IN NEONATAL LAMBS - (Peer Reviewed Journal)

Meyerholz, D.K., Grubor, B., Gallup, J.M., Lehmkuhl, H.D., Anderson, R.D., Lazic, T., Ackermann, M.R. 2004. Adenovirus-mediated gene therapy enhances parainfluenza virus 3 infection in neonatal lambs. Journal of Clinical Microbiology. 42(10):4780-4787.

RESPIRATORY SYNCYTIAL VIRUS INFECTION IN PRETERM LAMBS - (Abstract)

Meyerholz, D.K., Grubor, B., Fach, S.J., Sacco, R.E., Ensley, D., Lehmkuhl, H.D., Gallup, J.M., Ackermann, M.R. Respiratory syncytial virus infection in preterm lambs. 2004. Presented at FASEB Meeting. Abstract No. 1074.

ISOLATION OF AN ADENOVIRUS AND AN ADENO-ASSOCIATED VIRUS FROM GOAT KIDS WITH ENTERITIS - (Peer Reviewed Journal)

Olson, E.J., Haskell, S.R., Frank, R.K., Lehmkuhl, H.D., Hobbs, L.A., Warg, J.V., Landgraf, J., Wunschmann, A. 2004. Isolation of an adenovirus and an adeno-associated virus from goat kids with enteritis. Journal of Veterinary Diagnostic Investigation. 16:461-464.

ISOLATION OF A CLOSE AAV5 RELATIVE FROM GOAT TISSUE: EVIDENCE OF HOST PROMISCUITY - (Abstract)

Arbetman, A., Lochrie, M., Randlev, B., Surosky, R., Zhou, S., Wellman, J., Pater, C., Lehmkuhl, H.D., Hobbs, L.A., Pierce, G., Colosi, P. 2004. Isolation of a close AAAV5 relative from goat tissue: evidence of host promiscuity. Gene Therapy. Abstract #89.

ENHANCED SURFACTANT PROTEIN AND DEFENSIN MRNA LEVELS AND REDUCED VIRAL REPLICATION DURING PARAINFLUENZA VIRUS TYPE 3 PNEUMONIA IN NEONATAL LAMBS - (Peer Reviewed Journal)

Grubor, B., Gallup, J.M., Meyerholz, D.K., Crouch, E.C., Evans, R.B., Brogden, K.A., Lehmkuhl, H.D., Ackermann, M.R. 2004. Enhanced surfactant protein and defensin mrna levels and reduced viral replication during parainfluenza virus type 3 pneumonia in neonatal lambs. Clinical and Diagnostic Laboratory Immunology. 11(3):599-607.

THE EFFECTS OF BACTERIAL AND VIRAL PNEUMONIA ON SURFACTANT PROTEIN D MRNA EXPRESSION - (Abstract)

GRUBOR, B., MEYERHOLZ, D.K., GALLUP, J.M., BROGDEN, K.A., LEHMKUHL, H.D., ACKERMANN, M.R. THE EFFECTS OF BACTERIAL AND VIRAL PNEUMONIA ON SURFACTANT PROTEIN D MRNA EXPRESSION. AMERICAN COLLEGE OF VETERINARY PATHOLOGISTS ABSTRACTS. 2003. E4.

OVERVIEW OF RESEARCH AT THE NATIONAL ANIMAL DISEASE CENTER - (Abstract)

LEHMKUHL, H.D. OVERVIEW OF RESEARCH AT THE NATIONAL ANIMAL DISEASE CENTER. UNITED STATES JAPAN NATURAL RESOURCES ANIMAL AND AVIAN HEALTH PANEL. Oral presentation at the 38th Meeting of US-Japan Cooperative Program in Natural Resources, December 3, 2003 in Tsukuba, Japan. P. 29. Abstract.

CLINICAL AND PATHOLOGICAL PARAMETERS OF PARAINFLUENZA VIRUS-3 INFECTION IN NEONATAL LAMBS WITH CONCURRENT ADENOVIRAL-MEDIATED BETA-DEFENSIN GENE THERAPY - (Abstract)

MEYERHOLZ, D.K., ANDERSON, R.D., HASKELL, R.E., LEHMKUHL, H.D., GRUBOR, B.M., GALLUP, J.M., ACKERMANN, M.R. CLINICAL AND PATHOLOGICAL PARAMETERS OF PARAINFLUENZA VIRUS-3 INFECTION IN NEONATAL LAMBS WITH CONCURRENT ADENOVIRAL-MEDIATED BETA-DEFENSIN GENE THERAPY. AMERICAN COLLEGE OF VETERINARY PATHOLOGISTS ABSTRACTS. Vet. Pathol. 40:5, 603, Abstract #42.

LAMB AGE AFFECTS SUSCEPTIBILITY AND LESION SEVERITY IN BOVINE RESPSIRATORY SYNCYTIAL VIRUS INFECTION - (Abstract)

MEYERHOLZ, D.K., GRUBOR, B.M., GALLUP, J.M., LEHMKUHL, H.D., ACKERMANN, M.R. LAMB AGE AFFECTS SUSCEPTIBILITY AND LESION SEVERITY IN BOVINE RESPSIRATORY SYNCYTIAL VIRUS INFECTION. AMERICAN COLLEGE OF VETERINARY PATHOLOGISTS ABSTRACTS. Vet. Pathol. 39:5, 2003, p. 633, Abstract #84.

GENOMES OF THE PARAPOXVIRUSES OF ORF VIRUS AND BOVINE PAPULAR STOMATITIS VIRUS - (Peer Reviewed Journal)

Delhon, G., Tulman, E.R., Afonso, C.L., Lu, Z., Concha-Bermejillo, A., Lehmkuhl, H.D., Piccone, M.E., Kutish, G.F., Rock, D.L. 2004. Genomes of the parapoxviruses of ORF virus and bovine papular stomatitis virus. Journal of Virology. 78(1):168-177.

NEED FOR WILDLIFE SPECIFIC TOOLS: CHARACTERIZATION OF AN ADENOVIRUS THAT CAUSES HEMORRHAGIC DISEASE IN DEER - (Abstract)

LEHMKUHL, H.D., HOBBS, L.A., WOODS, L.W. NEED FOR WILDLIFE SPECIFIC TOOLS: CHARACTERIZATION OF AN ADENOVIRUS THAT CAUSES HEMORRHAGIC DISEASE IN DEER. DISEASES AT THE INTERFACE BETWEEN DOMESTIC LIVESTOCK AND WILDLIFE SPECIES. 2003. Abstract. P. 22.

ALTERATIONS OF SURFACTANT PROTEIN-A AND TUMOR NECROSIS FACTOR-ALPHA EXPRESSION DURING ACUTE BOVINE RESPIRATORY SYNCYTIAL VIRUS INFECTION - (Abstract)

MEYERHOLZ, D.K., GRUBOR, B., GALLUP, J.M., LEHMKUHL, H.D., EVANS, R.B., ACKERMANN, M.R. ALTERATIONS OF SURFACTANT PROTEIN-A AND TUMOR NECROSIS FACTOR-ALPHA EXPRESSION DURING ACUTE BOVINE RESPIRATORY SYNCYTIAL VIRUS INFECTION. AMERICAN SOCIETY FOR MICROBIOLOGY ANNUAL MEETING. 2003. Abstract p. 675, #Z-004.

PARAINFLUENZA VIRUS-3 PULMONARY LESIONS ARE NOT ENHANCED BY BOVINE VIRAL DIARRHEA VIRUS - (Proceedings/Symposium)

GRUBOR, B., MEYERHOLZ, D.K., GALLUP, J.M., LEHMKUHL, H.D., ACKERMANN, M.R. PARAINFLUENZA VIRUS-3 PULMONARY LESIONS ARE NOT ENHANCED BY BOVINE VIRAL DIARRHEA VIRUS. VETERINARY PATHOLOGY PROCEEDINGS OF THE ANNUAL MEETING OF THE AMERICAN COLL. 2002. v. 39(5). p. 637, #97.

AN UPDATE OF ADENOVIRAL HEMORRHAGIC DISEASE IN MULE DEER IN CALIFORNIA - (Abstract)

SWIFT, P.K., WOODS, L.W., LEHMKUHL, H.D., JONES, K.R. AN UPDATE OF ADENOVIRAL HEMORRHAGIC DISEASE IN MULE DEER IN CALIFORNIA. WILDLIFE DISEASE ASSOCIATION ANNUAL MEETING. 2002. Abstract p. 144, #115.

PRELIMINARY INVESTIGATION OF SQUIRRELS AS A POSSIBLE RESERVOIR FOR DEER ADENOVIRUS (ORAL PRESENTATION) - (Abstract)

PARKER, J., WOODS, L.W., LEHMKUHL, H.D., STILLIAN, M.H. PRELIMINARY INVESTIGATION OF SQUIRRELS AS A POSSIBLE RESERVOIR FOR DEER ADENOVIRUS. 51st WILDLIFE DISEASE ASSOCIATION CONFERENCE. 2002. Abstract p. 98, #74.

PHYLOGENETIC AND SEROLOGIC ANALYSIS OF RUMINANT ATADENOVIRUSES - (Proceedings/Symposium)

LEHMKUHL, H.D., HOBBS, L.A. PHYLOGENETIC AND SEROLOGIC ANALYSIS OF RUMINANT ATADENOVIRUSES. XIIth INTERNATIONAL CONGRESS OF VIROLOGY. 2002. Abstract p. 311, #V-925.

BOVINE ADENOVIRUS SEROTYPE 7 INFECTIONS IN POSTWEANING CALVES - (Peer Reviewed Journal)

FENT, G.M., FULTON, R.W., SLAIKI, J.T., CASELTINE, S.L., LEHMKUHL, H.D., CONFER, A.W., PURDY, C.W., BRIGGS, R.E., LOAN, R.W., DUFF, G.C. BOVINE ADENOVIRUS SEROTYPE 7 INFECTIONS IN POSTWEANING CALVES. AMERICAN JOURNAL OF VETERINARY RESEARCH. 2002. V. 63(7); p. 976-978.

BRIEF REPORT: ODOCOILEUS HEMIONUS DEER ADENOVIRUS IS RELATED TO THE MEMBERS OF ATADENOVIRUS GENUS - (Peer Reviewed Journal)

ZAKHARTCHOUK, A., BOUT, A., WOODS, L.W., LEHMKUHL, H.D., HAVENGA, M.J. BRIEF REPORT: ODOCOILEUS HEMIONUS DEER ADENOVIRUS IS RELATED TO THE MEMBERS OF ATADENOVIRUS GENUS. ARCHIVES OF VIROLOGY. 2002. V. 147(4); p. 841-847.