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rubitecan
A semisynthetic agent related to camptothecin with potent antitumor and antiviral properties. Rubitecan binds to and inhibits the enzyme topoisomerase I and induces protein-linked DNA single-strand breaks, thereby blocking DNA and RNA synthesis in dividing cells; this agent also prevents repair of reversible single-strand DNA breaks. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
| Synonyms: | | 9-nitrocamptothecin
9-nitro-CPT
nitrocamptothecin | | | | US brand names: | | Camptogen
Orathecin | | | | Abbreviation: | | 9-NC | | | | Code name: | | RFS 2000 | | | | Chemical structure name: | | 9-Nitro-20 (S-)Camptothecin | | |
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