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trofosfamide
An orally bioavailable oxazaphosphorine prodrug with antineoplastic activity. Trofosfamide (TFF) is metabolized predominantly to the cyclophosphamide analogue ifosfamide (IFO), which is then metabolized by liver cytochrome P450s to the active isophosphoramide mustard (IPM). IPM alkylates DNA to form DNA-DNA cross-links, which may result in inhibition of DNA, RNA and protein synthesis, and tumor cell apoptosis. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
| Synonym: | | trofosfamid | | | | US brand name: | | Ixoten | | | | Foreign brand name: | | Genoxal Trofosfamida | | | | Abbreviation: | | TFF | | | | Code name: | | A-4828 | | | | Chemical structure names: | | - 2-[bis(2-chloroethyl)amino]-3-(2-chloroethyl)tetrahydro-2H-1,3,2-oxaphosphorine 2-oxide
- N,N,3-tris(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide
- N,N,N'-tris(2-chloroethyl)-N',O-propylene phosphoric acid ester diamide
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