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transferrin-CRM107
A synthetic targeted protein toxin which consists of human transferrin (Tf) conjugated to a diphtheria toxin that contains a point mutation (CRM107). After binding to the transferrin receptor expressed on the tumor cell surface, transferrin-CRM107 is internalized, where the diphtheria toxin moiety exerts its cytotoxic effect intracellularly by inhibiting protein synthesis through ADP-ribosylation of elongation factor. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
| Synonym: | | Tf-CRM107 | | | | US brand name: | | TransMID | | | | Code name: | | HN-66000 | | |
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