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halofuginone hydrobromide The hydrobromide salt of halofuginone, a semisynthetic quinazolinone alkaloid anticoccidial derived from the plant Dichroa febrifuga, with antifibrotic and potential antineoplastic activities. Halofuginone specifically inhibits collagen type I gene expression and matrix metalloproteinase 2 (MMP-2) gene expression, which may result in the suppression of angiogenesis, tumor stromal cell development, and tumor cell growth. These effects appear to be due to halofuginone-mediated inhibition of the collagen type I and MMP-2 promoters. Collagen type I and MMP-2 play important roles in fibro-proliferative diseases. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
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Synonyms: | ![](https://webarchive.library.unt.edu/eot2008/20090509171107im_/http://www.cancer.gov/images/spacer.gif) | halofuginone halofuginone HBr | | ![](https://webarchive.library.unt.edu/eot2008/20090509171107im_/http://www.cancer.gov/images/spacer.gif) | US brand name: | ![](https://webarchive.library.unt.edu/eot2008/20090509171107im_/http://www.cancer.gov/images/spacer.gif) | Tempostatin | | ![](https://webarchive.library.unt.edu/eot2008/20090509171107im_/http://www.cancer.gov/images/spacer.gif) | Code name: | ![](https://webarchive.library.unt.edu/eot2008/20090509171107im_/http://www.cancer.gov/images/spacer.gif) | RU 19110 | | ![](https://webarchive.library.unt.edu/eot2008/20090509171107im_/http://www.cancer.gov/images/spacer.gif) |
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