 |
|
peplomycin
A semisynthetic analog of Bleomycin, a mixture of several basic glycopeptide antineoplastic antibiotics isolated from the fungus Streptomyces verticillus. Peplomycin forms complexes with iron that reduce molecular oxygen to superoxide and hydroxyl radicals that cause single- and double-stranded breaks in DNA. This agent appears to show greater antitumor activity than bleomycin; its use is limited due to pulmonary toxicity. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
| Synonym: | | pepleomycin | | | | Abbreviation: | | PEP | | | | Chemical structure names: | | - (S)-n1-[3-[(1-phenylethyl)amino]propyl]bleomycinamide
- n1-[3[[(S)-alpha-methylbenzyl]amino]propyl]bleomycinamide
| | |
|
|
