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PI3K delta inhibitor CAL-101 A small molecule inhibitor of the delta isoform of the 110 kDa catalytic subunit of class IA phosphoinositide-3 kinases (PI3K) with potential immunomodulating and antineoplastic activities. PI3K-delta inhibitor CAL-101 inhibits the production of the second messenger phosphatidylinositol-3,4,5-trisphosphate (PIP3), preventing the activation of the PI3K signaling pathway and thus inhibiting tumor cell proliferation, motility, and survival. Unlike other isoforms of PI3K, PI3K-delta is expressed primarily in hematopoietic lineages. The targeted inhibition of PI3K-delta is designed to preserve PI3K signaling in normal, non-neoplastic cells. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
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Synonym: | ![](https://webarchive.library.unt.edu/eot2008/20090509192730im_/http://www.cancer.gov/images/spacer.gif) | phosphoinositide-3 kinase delta inhibitor CAL-101 | | ![](https://webarchive.library.unt.edu/eot2008/20090509192730im_/http://www.cancer.gov/images/spacer.gif) | Code name: | ![](https://webarchive.library.unt.edu/eot2008/20090509192730im_/http://www.cancer.gov/images/spacer.gif) | CAL-101 | | ![](https://webarchive.library.unt.edu/eot2008/20090509192730im_/http://www.cancer.gov/images/spacer.gif) |
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