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PNP-expressing ovine atadenovirus FP253 An ovine atadenovirus encoding E. coli purine nucleoside phosphorylase (PNP) with prodrug activating activity. Under the control of a prostate-directed promoter, PNP-expressing atadenovirus vaccine FP253 expresses PNP in prostate tissue only after intraprostatic administration; this enzyme catalyzes systemically administered fludarabine prodrug into the active agent, 2-fluoroadenine. Localized prodrug activation provides prostate-targeted chemotherapy, potentially reducing systemic side effects.
Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
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Code name: | ![](https://webarchive.library.unt.edu/eot2008/20090509195442im_/http://www.cancer.gov/images/spacer.gif) | FP253 | | ![](https://webarchive.library.unt.edu/eot2008/20090509195442im_/http://www.cancer.gov/images/spacer.gif) |
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