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darbepoetin alfa A recombinant analog of the endogenous cytokine erythropoietin, an erythropoiesis-stimulating protein. Due to the addition of two carbohydrate chains, darbepoetin alfa exhibits a three-fold greater half-life than does erythropoietin. Similar to erythropoietin, darbopoietin alfa binds to and activates epoetin receptors, thereby inducing the differentiation and maturation of erythrocyte progenitors, stimulating endothelial cell proliferation, and stimulating B-cell proliferation and immunoglobulin production. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
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Synonym: | ![](https://webarchive.library.unt.edu/eot2008/20090509191507im_/http://www.cancer.gov/images/spacer.gif) | Novel Erythropoiesis Stimulating Protein | | ![](https://webarchive.library.unt.edu/eot2008/20090509191507im_/http://www.cancer.gov/images/spacer.gif) | US brand name: | ![](https://webarchive.library.unt.edu/eot2008/20090509191507im_/http://www.cancer.gov/images/spacer.gif) | Aranesp | | ![](https://webarchive.library.unt.edu/eot2008/20090509191507im_/http://www.cancer.gov/images/spacer.gif) | Foreign brand name: | ![](https://webarchive.library.unt.edu/eot2008/20090509191507im_/http://www.cancer.gov/images/spacer.gif) | Nespo | | ![](https://webarchive.library.unt.edu/eot2008/20090509191507im_/http://www.cancer.gov/images/spacer.gif) | Abbreviation: | ![](https://webarchive.library.unt.edu/eot2008/20090509191507im_/http://www.cancer.gov/images/spacer.gif) | NESP | | ![](https://webarchive.library.unt.edu/eot2008/20090509191507im_/http://www.cancer.gov/images/spacer.gif) | Code name: | ![](https://webarchive.library.unt.edu/eot2008/20090509191507im_/http://www.cancer.gov/images/spacer.gif) | KRN321 | | ![](https://webarchive.library.unt.edu/eot2008/20090509191507im_/http://www.cancer.gov/images/spacer.gif) |
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