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denileukin diftitox A cytotoxic recombinant protein consisting of interleukin-2 (IL-2) protein sequences fused to diphtheria toxin. The IL-2 protein sequence moiety of denileukin difitox directs the cytocidal action of diphtheria toxin to cells that express IL-2 receptors. After the toxin moiety is internalized into target IL-2 receptor-expressing cells, its catalytic domain catalyzes the transfer of the ADP-ribose moiety of NAD to a posttranslationally modified histidine residue of elongation factor 2 (EF-2), called diphthamine. This covalent modification inactivates EF-2 and disrupts polypeptide chain elongation, resulting in cell death. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
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Synonyms: | ![](https://webarchive.library.unt.edu/eot2008/20090509191630im_/http://www.cancer.gov/images/spacer.gif) | DAB(389)-interleukin-2 DAB389 interleukin-2 DAB389 interleukin-2 immunotoxin DABIL2 | | ![](https://webarchive.library.unt.edu/eot2008/20090509191630im_/http://www.cancer.gov/images/spacer.gif) | US brand name: | ![](https://webarchive.library.unt.edu/eot2008/20090509191630im_/http://www.cancer.gov/images/spacer.gif) | ONTAK | | ![](https://webarchive.library.unt.edu/eot2008/20090509191630im_/http://www.cancer.gov/images/spacer.gif) | Abbreviation: | ![](https://webarchive.library.unt.edu/eot2008/20090509191630im_/http://www.cancer.gov/images/spacer.gif) | DAB389-IL2 | | ![](https://webarchive.library.unt.edu/eot2008/20090509191630im_/http://www.cancer.gov/images/spacer.gif) | Code name: | ![](https://webarchive.library.unt.edu/eot2008/20090509191630im_/http://www.cancer.gov/images/spacer.gif) | LY335348 | | ![](https://webarchive.library.unt.edu/eot2008/20090509191630im_/http://www.cancer.gov/images/spacer.gif) |
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