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genistein
A soy-derived isoflavone and phytoestrogen with antineoplastic activity. Genistein binds to and inhibits protein-tyrosine kinase, thereby disrupting signal transduction and inducing cell differentiation. This agent also inhibits topoisomerase-II, leading to DNA fragmentation and apoptosis, and induces G2/M cell cycle arrest. Genistein exhibits antioxidant, antiangiogenic, and immunosuppressive activities. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
| Synonyms: | | CI 75610
Genestein
genisteol
genisterin
prunetol
sophoricol | | | | Chemical structure names: | | - 4',5,7-trihydroxyisoflavone
- 5,7-dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
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