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gusperimus A derivative of the antitumor antibiotic spergualin with immunosuppressant activity. Gusperimus inhibits the interleukin-2-stimulated maturation of T cells to the S and G2/M phases and the polarization of the T cells into IFN-gamma-secreting Th1 effector T cells, resulting in the inhibition of growth of activated naive CD4 T cells; this agent may suppress growth of certain T-cell leukemia cell lines. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
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Synonyms: | ![](https://webarchive.library.unt.edu/eot2008/20090509185103im_/http://www.cancer.gov/images/spacer.gif) | deoxyspergualin Deoxyspergualin Hydrochloride Gusperimus Trihydrochloride | | ![](https://webarchive.library.unt.edu/eot2008/20090509185103im_/http://www.cancer.gov/images/spacer.gif) | Foreign brand name: | ![](https://webarchive.library.unt.edu/eot2008/20090509185103im_/http://www.cancer.gov/images/spacer.gif) | Spanidin | | ![](https://webarchive.library.unt.edu/eot2008/20090509185103im_/http://www.cancer.gov/images/spacer.gif) | Abbreviation: | ![](https://webarchive.library.unt.edu/eot2008/20090509185103im_/http://www.cancer.gov/images/spacer.gif) | DSG | | ![](https://webarchive.library.unt.edu/eot2008/20090509185103im_/http://www.cancer.gov/images/spacer.gif) | Code names: | ![](https://webarchive.library.unt.edu/eot2008/20090509185103im_/http://www.cancer.gov/images/spacer.gif) | BMS-181173 BMY-42215-1 NKT-01 | | ![](https://webarchive.library.unt.edu/eot2008/20090509185103im_/http://www.cancer.gov/images/spacer.gif) | Chemical structure names: | ![](https://webarchive.library.unt.edu/eot2008/20090509185103im_/http://www.cancer.gov/images/spacer.gif) | - 15-deoxyspergualin hydrochloride
- 1-amino-19-guanidino-11-hydroxy-4,9,12-triazanonadecane-10,13-dione
- 7-{(aminoiminomethyl)amino]-N-[2-[[4-[(3-aminopropyl)amino]butyl]amnio]-1-hydroxy-2-oxoethyl]heptanamide
- N-[[[4-[(3-Aminopropyl)amino]-butyl]carbamoyl]hydroxymethyl]-7-guanidinoheptanamide
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