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Copyright © 2009 Cochrane; licensee BioMed Central Ltd. Inhibition of HIV-1 gene expression by Sam68ΔC: multiple targets but a common mechanism? Alan Cochrane  11Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada Corresponding author.Alan Cochrane: alan.cochrane/at/utoronto.ca Received February 11, 2009; Accepted March 2, 2009. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | ||||
Abstract Two recent publications have explored the mechanisms by which a mutant of the host protein Sam68 blocks HIV-1 structural protein synthesis and expands its activity to encompass Nef. Although the two studies propose different mechanisms for the responses observed, it is possible that a common activity is responsible. Understanding how this Sam68 mutant discriminates among the multiple viral mRNAs promises to reveal unique properties of HIV-1 RNA metabolism. | ||||
