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epothilone ZK-219477
A novel synthetic epothilone with potential antineoplastic activity. Epothilone ZK-219477 binds to microtubules, predominantly in tumor cells, thereby inducing microtubule bundling, formation of multipolar spindles, and mitotic arrest in a manner similar to taxanes. Epothilones are poor substrates for the multidrug resistance 1 (MDR1) P-glycoprotein drug efflux pump and, unlike the taxanes, appear to be able to evade some drug-resistance mechanisms. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
| Synonym: | | ZK-Epothilone | | | | Code names: | | SHY03757
ZK-219477 | | |
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