Research and research training are aimed at elucidating how normal and pathological aging affect the nervous system and encompass areas of neuroscience (exclusive of research on the dementias of aging) in the following categories:
Fundamental Neuroscience—Research at the cellular and molecular level that elucidates age-related structural and functional changes. Areas of special interest include:
Fundamental Neuroscience—Research at the cellular and molecular level that elucidates age-related structural and functional changes.
Areas of special interest include:
Integrative Neurobiology—Research on neural mechanisms underlying age-related changes in endocrine functions, neurodegenerative diseases of aging associated with infectious agents, and central nervous system, neuroendocrine system, and immune system interactions in aging. One major focus is on the neural control of the senescence of reproductive function and the reciprocal control of the relevant hypothalamic regions by the gonadal hormones. Sleep and Biological Rhythms—Research on epidemiology, etiology, pathogenesis, diagnosis, treatment, and prevention of sleep disorders of older people. Other areas of research include age-related mechanisms underlying sleep-wakefulness cycles and behavioral sequelae in the aged; effects of normal and disordered biological rhythmicity on the aging nervous system; and cellular and molecular mechanisms controlling biological rhythmicity within the aging nervous system. Sensory Processes—Research on mechanisms of normal aging and disease-related alterations in visual, auditory, somatosensory, and chemosensory functions from the whole organism to the gene. Areas of special research interest include clarifying how cellular, molecular, and central mechanisms affect the age-associated changes in hearing, vision, and the chemical and proprioceptive senses and their interactions as multimodal systems. Motor Function—Research on proprioception, postural control, sensory-guided movement, vestibular, and movement disorders in aging.
Integrative Neurobiology—Research on neural mechanisms underlying age-related changes in endocrine functions, neurodegenerative diseases of aging associated with infectious agents, and central nervous system, neuroendocrine system, and immune system interactions in aging.
One major focus is on the neural control of the senescence of reproductive function and the reciprocal control of the relevant hypothalamic regions by the gonadal hormones.
Sleep and Biological Rhythms—Research on epidemiology, etiology, pathogenesis, diagnosis, treatment, and prevention of sleep disorders of older people.
Other areas of research include age-related mechanisms underlying sleep-wakefulness cycles and behavioral sequelae in the aged; effects of normal and disordered biological rhythmicity on the aging nervous system; and cellular and molecular mechanisms controlling biological rhythmicity within the aging nervous system.
Sensory Processes—Research on mechanisms of normal aging and disease-related alterations in visual, auditory, somatosensory, and chemosensory functions from the whole organism to the gene.
Areas of special research interest include clarifying how cellular, molecular, and central mechanisms affect the age-associated changes in hearing, vision, and the chemical and proprioceptive senses and their interactions as multimodal systems.
Motor Function—Research on proprioception, postural control, sensory-guided movement, vestibular, and movement disorders in aging.
Research to better understand the alterations in attention, cognition, affect, language, learning, and memory that occur with normal aging in the following categories:
Cognitive Neuroscience—Research on the mechanisms underlying how attention, learning, memory, spatial orientation, language, affect, reasoning, decisionmaking, and judgment may change with age and experience. Examples include:
Cognitive Neuroscience—Research on the mechanisms underlying how attention, learning, memory, spatial orientation, language, affect, reasoning, decisionmaking, and judgment may change with age and experience.
Examples include:
Research on basic, clinical, and epidemiological studies of the etiology, diagnosis, and treatment of Alzheimer's disease and other dementias and treatable brain disorders of older people in the following categories:
Basic Research—Research on the etiology of Alzheimer's disease and other age-related neurodegenerative disorders. Areas of research interest include studies to identify genetic loci associated with inherited forms of these diseases and biochemical and molecular genetic analysis of the components of amyloid plaques, neurofibrillary tangles, and other abnormal structures found in the brains of people with Alzheimer's disease. Population Studies—Research on the epidemiology of Alzheimer's disease and models for large area registries for Alzheimer's disease and other dementing diseases of later life.
Basic Research—Research on the etiology of Alzheimer's disease and other age-related neurodegenerative disorders.
Areas of research interest include studies to identify genetic loci associated with inherited forms of these diseases and biochemical and molecular genetic analysis of the components of amyloid plaques, neurofibrillary tangles, and other abnormal structures found in the brains of people with Alzheimer's disease.
Population Studies—Research on the epidemiology of Alzheimer's disease and models for large area registries for Alzheimer's disease and other dementing diseases of later life.
Clinical Studies—Research on the diagnosis, treatment, and management of patients with Alzheimer's disease. Areas of research include:
Clinical Studies—Research on the diagnosis, treatment, and management of patients with Alzheimer's disease.
Areas of research include:
Research on treatment and management of Alzheimer's disease include:
Research Center—Alzheimer's Disease Centers (ADC) Program. ADC supports a multifaceted approach to Alzheimer's disease, including clinical and other core services, basic and clinical research, professional and public information, and educational activities. The ADC provides core resources that serve as the foundation for the development of expanded multidisciplinary research activities in Alzheimer's disease.
Research Center—Alzheimer's Disease Centers (ADC) Program.
ADC supports a multifaceted approach to Alzheimer's disease, including clinical and other core services, basic and clinical research, professional and public information, and educational activities. The ADC provides core resources that serve as the foundation for the development of expanded multidisciplinary research activities in Alzheimer's disease.
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