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HPPH
A lipophilic, second-generation, chlorin-based photosensitizer. Upon intravenous administration, HPPH selectively accumulates in the cytoplasm of cancer or pre-cancerous cells. When laser light is applied, a photodynamic reaction between HPPH and oxygen occurs, resulting in the production of cytotoxic free radicals and singlet oxygen and free radical-mediated cell death. Compared to the first-generation photosensitizer porfimer sodium, HPPH shows improved pharmacokinetic properties and causes only mild skin photosensitivity which declines rapidly within a few days after administration. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
| US brand name: | | Photochlor | | | | Chemical structure name: | | 2-(1-Hexyloxyethyl)-2-Devinyl Pyropheophorbide-a | | |
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