Structure and Function of the Anthrax Toxin Pore |
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| Air date: | Tuesday, December 02, 2008, 3:00:00 PM |
| Category: | Wednesday Afternoon Lectures |
| Runtime: | 60 minutes |
| NLM Title: | Structure and function of the anthrax toxin pore [electronic resource] / R. John Collier. |
| Series: | NIH director's Wednesday afternoon lecture series |
| Author: | Collier, R John. National Institutes of Health (U.S.) |
| Publisher: | [Bethesda, Md. : National Institutes of Health, 2008] |
| Other Title(s): | NIH director's Wednesday afternoon lecture series |
| Abstract: | (CIT): Anthrax toxin represents an interesting example of how a proteinaceous pore transports large globular proteins across a biological membrane. One component of the toxin, termed protective antigen (PA), forms an oligomeric pore in the endosomal membrane and translocates the two enzymatic moieties of the toxin, the lethal factor and the edema factor, across the membrane to the cytosolic compartment. This presentation will summarize current knowledge of the structure of the pore, how it inserts into the endosomal membrane, and how it mediates translocation of its substrate proteins across the bilayer. |
| Subjects: | Bacillus anthracis Bacterial Toxins Pore Forming Cytotoxic Proteins Protein Transport |
| Publication Types: | Government Publications Lectures |
| Download: | Download
Video How to download a Videocast |
| NLM Classification: | QU 55.7 |
| NLM ID: | 101493072 |
| CIT File ID: | 14804 |
| CIT Live ID: | 7022 |
| Permanent link: | http://videocast.nih.gov/launch.asp?14804 |
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Enhanced Audio Podcast | 1:06:01 |
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Enhanced Video Podcast | 1:06:01 | |