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recombinant interleukin-11 A recombinant therapeutic agent which is chemically identical to or similar to the endogenous cytokine interleukin 11 (IL-11). Secreted by bone marrow stromal cells and a number of mesenchymal cells, IL-11 binds to and activates its cell-surface receptor, promoting primary and secondary immune responses, modulating antigen-specific antibody reactions, and preventing apoptotic cell death. This agent also stimulates the T-cell-dependent development of IgG-secreting B-cells in spleen cell cultures and may be an important regulator of megakaryocytopoiesis. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
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Synonyms: | ![](https://webarchive.library.unt.edu/eot2008/20090509195806im_/http://www.cancer.gov/images/spacer.gif) | adipogenesis inhibitory factor IL-11 interleukin 11 Oprelvekin recombinant human interleukin-11 therapeutic interleukin-11 | | ![](https://webarchive.library.unt.edu/eot2008/20090509195806im_/http://www.cancer.gov/images/spacer.gif) | US brand name: | ![](https://webarchive.library.unt.edu/eot2008/20090509195806im_/http://www.cancer.gov/images/spacer.gif) | Neumega | | ![](https://webarchive.library.unt.edu/eot2008/20090509195806im_/http://www.cancer.gov/images/spacer.gif) | Abbreviation: | ![](https://webarchive.library.unt.edu/eot2008/20090509195806im_/http://www.cancer.gov/images/spacer.gif) | rhIL-11 | | ![](https://webarchive.library.unt.edu/eot2008/20090509195806im_/http://www.cancer.gov/images/spacer.gif) |
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