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fluphenazine hydrochloride The hydrochloride salt of fluphenazine, a phenothiazine with antipsychotic activity and potential antineoplastic activity. Fluphenazine blocks postsynaptic dopamine D2 receptors in the limbic system, cortical system and basal ganglia, resulting a reduction of schizophrenia-associated hallucinations and delusions. In addition, as a serotonin antagonist, this agent may inhibit lymphocyte and myeloma cell proliferation by blocking 5-hydroxytrptamine type 1B (5-HT type 1B) receptors for serotonin. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
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US brand names: | ![](https://webarchive.library.unt.edu/eot2008/20090509172712im_/http://www.cancer.gov/images/spacer.gif) | Permitil Prolixin | | ![](https://webarchive.library.unt.edu/eot2008/20090509172712im_/http://www.cancer.gov/images/spacer.gif) |
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