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HDAC inhibitor CHR-3996 An orally bioavailable, second-generation hydroxamic acid-based inhibitor of histone deacetylase (HDAC) with potential antineoplastic activity. HDAC inhibitor CHR-3996 inhibits HDAC, resulting in an accumulation of highly acetylated histones, the induction of chromatin remodeling, and the selective transcription of tumor suppressor genes; these events may result in the inhibition of tumor cell division and the induction of tumor cell apoptosis. This agent may upregulate HSP70 and downregulate anti-apoptotic Bcl-2 proteins more substantially than some first-generation HDAC inhibitors. HDACs, upregulated in many tumor cell types, are a family of metalloenzymes responsible for the deacetylation of chromatin histone proteins. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
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Synonym: | ![](https://webarchive.library.unt.edu/eot2008/20090509165759im_/http://www.cancer.gov/images/spacer.gif) | histone eacetylase inhibitor CHR-3996 | | ![](https://webarchive.library.unt.edu/eot2008/20090509165759im_/http://www.cancer.gov/images/spacer.gif) | Code name: | ![](https://webarchive.library.unt.edu/eot2008/20090509165759im_/http://www.cancer.gov/images/spacer.gif) | CHR-3996 | | ![](https://webarchive.library.unt.edu/eot2008/20090509165759im_/http://www.cancer.gov/images/spacer.gif) |
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