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trimethoprim-sulfamethoxazole A synthetic combination of two antibacterial agents, trimethoprim and sulfamethoxazole. This synergistic combination, also known as co-trimoxazole, inhibits two sequential steps in the bacterial metabolism of folic acid. Trimethoprim is a pyrimidine inhibitor of dihydrofolate reductase; sulfamethoxazole is a sulfamide inhibitor of bacterial dihydrofolate synthetase. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
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Synonyms: | ![](https://webarchive.library.unt.edu/eot2008/20090509165239im_/http://www.cancer.gov/images/spacer.gif) | cotrimoxazole Eslectin insozalin trimedin trimezole | | ![](https://webarchive.library.unt.edu/eot2008/20090509165239im_/http://www.cancer.gov/images/spacer.gif) | US brand names: | ![](https://webarchive.library.unt.edu/eot2008/20090509165239im_/http://www.cancer.gov/images/spacer.gif) | Bactrim Cotrim Septra Sulfamethoprim Sulfatrim Sulmeprim | | ![](https://webarchive.library.unt.edu/eot2008/20090509165239im_/http://www.cancer.gov/images/spacer.gif) | Abbreviations: | ![](https://webarchive.library.unt.edu/eot2008/20090509165239im_/http://www.cancer.gov/images/spacer.gif) | SMZ-TMP TMP-SMX | | ![](https://webarchive.library.unt.edu/eot2008/20090509165239im_/http://www.cancer.gov/images/spacer.gif) |
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