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sulindac A sulfinylindene derivative prodrug with potential antineoplastic activity. Converted in vivo to an active metabolite, sulindac, a nonsteroidal anti-inflammatory drug (NSAID), blocks cyclic guanosine monophosphate-phosphodiesterase (cGMP-PDE), an enzyme that inhibits the normal apoptosis signal pathway; this inhibition permits the apoptotic signal pathway to proceed unopposed, resulting in apoptotic cell death. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
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Synonym: | ![](https://webarchive.library.unt.edu/eot2008/20090509153735im_/http://www.cancer.gov/images/spacer.gif) | Sulindac Sulfoxide | | ![](https://webarchive.library.unt.edu/eot2008/20090509153735im_/http://www.cancer.gov/images/spacer.gif) | US brand names: | ![](https://webarchive.library.unt.edu/eot2008/20090509153735im_/http://www.cancer.gov/images/spacer.gif) | Aflodac Clinoril | | ![](https://webarchive.library.unt.edu/eot2008/20090509153735im_/http://www.cancer.gov/images/spacer.gif) | Foreign brand names: | ![](https://webarchive.library.unt.edu/eot2008/20090509153735im_/http://www.cancer.gov/images/spacer.gif) | Algocetil Apo-Sulin Arthrocine Artribid Citireuma Clisundac Imbaral Novo-Sundac Reumofil Reumyl Sudac Sulinol Sulreuma | | ![](https://webarchive.library.unt.edu/eot2008/20090509153735im_/http://www.cancer.gov/images/spacer.gif) | Abbreviation: | ![](https://webarchive.library.unt.edu/eot2008/20090509153735im_/http://www.cancer.gov/images/spacer.gif) | SULIN | | ![](https://webarchive.library.unt.edu/eot2008/20090509153735im_/http://www.cancer.gov/images/spacer.gif) | Code name: | ![](https://webarchive.library.unt.edu/eot2008/20090509153735im_/http://www.cancer.gov/images/spacer.gif) | MK-231 | | ![](https://webarchive.library.unt.edu/eot2008/20090509153735im_/http://www.cancer.gov/images/spacer.gif) | Chemical structure names: | ![](https://webarchive.library.unt.edu/eot2008/20090509153735im_/http://www.cancer.gov/images/spacer.gif) | - (Z)-5-fluoro-2-methyl-1-[[4-(methylsulfinyl)phenyl]methylene]-1H-indene-3-acetic acid
- cis-5-fluoro-2-methyl-1-[p-(methylsulfinyl)benzylidene]indene-3-acetic acid
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