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azathioprine sodium The sodium salt form of azathioprine, a pro-drug of purine analogue with immunosuppressive activity. Azathioprine is converted in vivo to its active metabolite 6-mercaptopurine (6-MP), which substitutes for the normal nucleoside and mistakenly gets incorporated into DNA sequences. This leads to inhibition of DNA, RNA, and protein synthesis. As a result, cell proliferation may be inhibited, particularly in lymphocytes and leukocytes. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
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US brand name: | ![](https://webarchive.library.unt.edu/eot2008/20090509212908im_/http://www.cancer.gov/images/spacer.gif) | Imuran | | ![](https://webarchive.library.unt.edu/eot2008/20090509212908im_/http://www.cancer.gov/images/spacer.gif) | Foreign brand name: | ![](https://webarchive.library.unt.edu/eot2008/20090509212908im_/http://www.cancer.gov/images/spacer.gif) | Imurel | | ![](https://webarchive.library.unt.edu/eot2008/20090509212908im_/http://www.cancer.gov/images/spacer.gif) | Abbreviations: | ![](https://webarchive.library.unt.edu/eot2008/20090509212908im_/http://www.cancer.gov/images/spacer.gif) | AZA AZTP | | ![](https://webarchive.library.unt.edu/eot2008/20090509212908im_/http://www.cancer.gov/images/spacer.gif) |
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