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NCI Drug Dictionary

metformin hydrochloride
The hydrochloride salt of the biguanide metformin with antihyperglycemic activity. Metformin decreases hepatic gluconeogenesis and intestinal absorption of glucose. This agent also increases the number and/or affinity of insulin receptors on muscle and adipose cells, increasing the sensitivity to insulin at receptor and post-receptor binding sites and increasing glucose uptake peripherally. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)

US brand name:Glucophage
Chemical structure names:
  • 1,1-dimethylbiguanide hydrochloride
  • N,N-dimethylimidodicarbonimidic diamide monohydrochloride

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