Genome Architecture, Rearrangements, Evolution and Genomic Disorders |
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| Launch in standalone player | |
| Air date: | Wednesday, April 21, 2004, 3:00:00 PM |
| Category: | Wednesday Afternoon Lectures |
| Description: | The term "genomic disorder" refers to a disease that is caused by an alteration of the genome that results in complete loss, gain, or disruption of the structural integrity of a dosage sensitive gene(s). In most of the common chromosome deletion/duplication syndromes, the rearranged genomic segments are flanked by large (usually>10kb), highly homologous low copy repeat (LCR) structures that can act as recombination substrates. Recombination between non-allelic LCR copies, also known as non-allelic homologous recombination (NAHR), can result in deletion or duplication of the intervening segment.
For more information, visit James Lupski The NIH Director's Wednesday Afternoon Lecture Series |
| Author: | James R. Lupski, M.D., Ph.D. Baylor College of Medicine |
| Runtime: | 75 minutes |
| Rights: | This is a work of the United States Government. No copyright exists on this material. It may be disseminated freely. |
| Download: | Download
Video How to download a Videocast |
| CIT File ID: | 11982 |
| CIT Live ID: | 2624 |
| Permanent link: | http://videocast.nih.gov/launch.asp?11982 |