Retroviral Insertional Mutagenesis: A Roadmap for Navigating the Cancer Genome |
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| Launch in standalone player | |
| Air date: | Wednesday, March 24, 2004, 3:00:00 PM |
| Category: | Wednesday Afternoon Lectures |
| Description: | Inbred mouse strains such as BXH2 or AKXD have high spontaneous incidences of leukemia or lymphoma and provide important mouse models for the study of human hematopoietic disease. Tumors in these mice are caused by retroviruses these mice inherit from their parents. These retroviruses do not carry oncogenes in their genome; rather, they induce disease by integrating into the genome of hematopoietic cells and occasionally deregulating the expression of a proto-oncogene or inactivating the expression of a tumor suppressor gene. The integrated retroviruses in these tumors thus provide powerful molecular tags for cancer gene identification.
For more information, visit Neal G. Copeland and Nancy A. Jenkins The NIH Director's Wednesday Afternoon Lecture Series |
| Author: | Neal G. Copeland, Ph.D. and Nancy A. Jenkins, Ph.D. |
| Runtime: | 75 minutes |
| Rights: | This is a work of the United States Government. No copyright exists on this material. It may be disseminated freely. |
| Download: | Download
Video How to download a Videocast |
| CIT File ID: | 11937 |
| CIT Live ID: | 2620 |
| Permanent link: | http://videocast.nih.gov/launch.asp?11937 |