Towards Imaging Biomarkers for Osteoarthritis: Surprises, Challenges, and Opportunities |
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| Launch in standalone player | |
| Air date: | Wednesday, January 21, 2009, 3:00:00 PM |
| Category: | Wednesday Afternoon Lectures |
| Runtime: | 60 minutes |
| NLM Title: | Towards imaging biomarkers for osteoarthritis : surprises, challenges, and opportunities [electronic resource] / Martha Gray. |
| Series: | NIH director's Wednesday afternoon lecture series |
| Author: | Gray, Martha. National Institutes of Health (U.S.) |
| Publisher: | [Bethesda, Md. : National Institutes of Health, 2009] |
| Other Title(s): | NIH director's Wednesday afternoon lecture series |
| Abstract: | (CIT): Many new therapeutic strategies have been and are being developed to correct, prevent, or slow the progression of osteoarthritis (OA). Our ability to evaluate the efficacy of these techniques, or to determine the situations for which they might provide the most benefit, critically depends on diagnostic measures that can serve as proxies or "biomarkers" for the present or predicted state of the cartilage. Accordingly, much research over the past decade has been devoted to the development of biomarkers for OA, including considerable efforts towards developing imaging biomarkers for OA. Biomarker development requires two phases of validation. The first is technical validity: is the marker measuring what it aims to measure? The second is pathophysiologic validity: is the information provided by the marker of pathophysiological or clinical use? Many of the magnetic resonance imaging techniques that have been emerging over the past decades appear promising in that they have shown technical validity in measuring the morphologic and molecular state of cartilage, and with emerging clinical studies, efforts are beginning to offer evidence regarding pathophysiological validity. As a case study, this talk will focus on biomarkers for glycosaminoglycan (GAG). In addition to illustrating technical and pathophysiological validity, and some of the surprising insights that have come along the way, we will also explore the way in which such biomarkers might change the scientific and clinical paradigm for advancing our understanding, diagnosis and treatment of osteoarthritis. |
| Subjects: | Biological Markers Cartilage--physiopathology Glycosaminoglycans Magnetic Resonance Imaging--methods Osteoarthritis |
| Publication Types: | Government Publications Lectures |
| Download: | Download
Video How to download a Videocast |
| NLM Classification: | WE 348 |
| NLM ID: | 101496163 |
| CIT File ID: | 14863 |
| CIT Live ID: | 7028 |
| Permanent link: | http://videocast.nih.gov/launch.asp?14863 |
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Enhanced Audio Podcast | 1:05:36 |
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Enhanced Video Podcast | 1:05:36 | |