Mechanisms and Therapeutic Applications of Immune Stimulatory Bacterial CpG DNA |
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| Launch in standalone player | |
| Air date: | Wednesday, May 26, 2004, 3:00:00 PM |
| Category: | Wednesday Afternoon Lectures |
| Description: | Unmethylated CpG dinucleotides in bacterial or viral DNA can engage the Toll-like receptor (TLR)9, thereby stimulating innate and adaptive immunity. These immune effects can be mimicked by synthetic oligodeoxynucleotides containing CpG motifs (CpG ODN). In humans only B cells and plasmacytoid dendritic cells (pDC) express TLR9 and are activated directly by CpG ODN. Depending on the structure and sequence of the CpG ODN, at least three distinct classes of immune effects can be induced. Depending on their class, CpG ODN activate B cells to proliferate and secrete immunoglobulin; and pDC to secrete a variety of Th1-like cytokines, chemokines, and type I interferons, and to express increased costimulatory molecules. When activated by CpG, pDC gain the ability to stimulate Th1-like T cell responses.
NIH Director's Wednesday Afternoon Lecture Series |
| Author: | Arthur M. Krieg, M.D., Coley Pharmaceutical Group |
| Runtime: | 60 minutes |
| Rights: | This is a work of the United States Government. No copyright exists on this material. It may be disseminated freely. |
| Download: | Download
Video How to download a Videocast |
| CIT File ID: | 12050 |
| CIT Live ID: | 2628 |
| Permanent link: | http://videocast.nih.gov/launch.asp?12050 |