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Pilot Phase II Study with Anguidine to Prevent Myelosuppression in Patients with Leukemia and Solid Tumors Treated with ARA-C
Basic Trial Information
Objectives I. Determine whether prior and concurrent treatment with low doses of anguidine can ameliorate or prevent myelosuppression in patients with leukemia and solid tumors treated with cytosine arabinoside. II. Determine the qualitative and quantitative toxicities associated with treatment with both of these agents. Entry Criteria Disease Characteristics: See General Eligibility Criteria Patient Characteristics: See General Eligibility Criteria General Eligibility Criteria: Patients with leukemia and solid tumors who might derive benefit from treatment with cytosine arabinoside. Expected Enrollment Protocol closed February 1983. Outline Nonrandomized study. Single-agent Chemotherapy plus Myeloprotective Therapy. Cytosine arabinoside, ARA-C, NSC-63878; plus Anguidine, ANG, NSC-141537. Trial Lead Organizations M. D. Anderson Cancer Center at University of Texas
Note: The purpose of most clinical trials listed in this database is to test new cancer treatments, or new methods of diagnosing, screening, or preventing cancer. Because all potentially harmful side effects are not known before a trial is conducted, dose and schedule modifications may be required for participants if they develop side effects from the treatment or test. The therapy or test described in this clinical trial is intended for use by clinical oncologists in carefully structured settings, and may not prove to be more effective than standard treatment. A responsible investigator associated with this clinical trial should be consulted before using this protocol. |
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