 |
|
anti-CD22 immunotoxin CAT-8015
A recombinant immunotoxin consisting of the Fv portion of the anti-CD22 antibody covalently fused to a 38 KDa fragment of Pseudomonas exotoxin-A (PE38) with potential antineoplastic activity. The Fv portion of anti-CD22 immunotoxin CAT-8015 binds to CD22, a cell surface receptor expressed on a variety of malignant B-cells, thereby delivering the toxin moiety PE38 directly to tumor cells. Once internalized, PE38 induces caspase-mediated apoptosis via a mechanism involving mitochondrial damage and blocks translational elongation by binding to elongation factor 2 (EF-2). Anti-CD22 immunotoxin CAT-8015 exhibits a greater affinity for CD22 than its predecessor, anti-CD22 immunotoxin CAT-3888 (BL22 immunotoxin), and hence may be more effective against tumor cells expressing lower levels of CD22. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
| Code name: | | CAT-8015 | | |
| Previous: | anti-CD19 fully human monoclonal antibody MDX-1342, anti-CD19-DM4 immunoconjugate SAR3419, anti-CD20 monoclonal antibody AME-133v, anti-CD20 monoclonal antibody R7159, anti-CD200 monoclonal antibody ALXN6000 | | Next: | anti-CD3 immunotoxin A-dmDT390-bisFv(UCHT1), anti-CD30 monoclonal antibody MDX-1401, anti-CD30 monoclonal antibody XmAb2513, anti-CD33 monoclonal antibody-DM4 conjugate AVE9633, anti-CD37 single-chain polypeptide TRU-016 |
|
|
