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anti-CD38 monoclonal antibody
A fully human monoclonal antibody directed against the cell surface glycoprotein CD-38 with potential antineoplastic activity. The binding of anti-CD38 monoclonal antibody to natural killer (NK) cells mimics the normal CD38-CD31 interaction on the NK cell surface. CD38 is also present on multiple myeloma (MM) cells and plasma leukemia cells; this agent may preferentially bind these cells, triggering antitumoral antibody-dependent
cellular cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC).
CD38, a cell surface glycoprotein, is present on various immune cells and has been shown to regulate the cytotoxic response of activated NK cells. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
| US brand name: | | HuMax-CD38 | | |
| Previous: | anti-CD3 immunotoxin A-dmDT390-bisFv(UCHT1), anti-CD30 monoclonal antibody MDX-1401, anti-CD30 monoclonal antibody XmAb2513, anti-CD33 monoclonal antibody-DM4 conjugate AVE9633, anti-CD37 single-chain polypeptide TRU-016 | | Next: | anti-CD45 monoclonal antibody, anti-CD45 monoclonal antibody AHN-12, anti-CD70 monoclonal antibody MDX-1411, anti-CEA IgCD28TCR-transduced autologous T cells, anti-CEA/anti-DTPA-In (F6-734) bispecific antibody |
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