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anti-CD3 immunotoxin A-dmDT390-bisFv(UCHT1)
A bivalent recombinant fusion protein immunotoxin derived from the anti-CD3 monoclonal antibody UCHT1 with potential antineoplastic activity. Anti-CD3 immunotoxin A-dmDT390-bisFv(UCHT1) consists of 1-390 amino acid residues of chain A diphtheria toxin (DT) joined via a spacer to the Fv fragment of UCHT1, which is connected to a second UCHT1 Fv fragment via a disulfide bond (hence the "bisFv" designation); the addition of the second Fv fragment overcomes the steric hindrance of immunotoxin binding due to the large N-terminal DT domain. Once inside target T cells, the DT moiety catalyzes the transfer of the ADP-ribose moiety of NAD to diphthamide, a posttranslationally modified histidine residue found in elongation factor 2 (EF-2); inactivation of EF-2, disruption of polypeptide chain elongation, and cell death ensue. CD3 is a complex of five cell-surface polypeptides associated with the T cell receptor (TCR) complex. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
| Synonyms: | | A-dmDT390-bisFv(UCHT1) fusion protein
anti-T cell immunotoxin A-dmDT390-bisFv(UCHT1) | | | | Abbreviation: | | A-dmDT390-bisFv(UCHT1) | | |
| Previous: | anti-CD19-DM4 immunoconjugate SAR3419, anti-CD20 monoclonal antibody AME-133v, anti-CD20 monoclonal antibody R7159, anti-CD200 monoclonal antibody ALXN6000, anti-CD22 immunotoxin CAT-8015 | | Next: | anti-CD30 monoclonal antibody MDX-1401, anti-CD30 monoclonal antibody XmAb2513, anti-CD33 monoclonal antibody-DM4 conjugate AVE9633, anti-CD37 single-chain polypeptide TRU-016, anti-CD38 monoclonal antibody |
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