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anti-CD45 monoclonal antibody
A monoclonal antibody directed against the receptor-like leukocyte cell surface glycoprotein CD45 with leukocyte-depleting activity. Upon administration, anti-CD45 monoclonal antibody binds to leukocyte surface-expressed CD45, which may result in the transient depletion of circulating leukocytes including circulating T cell depletion (TCD). CD45, a receptor-like protein-tyrosine phosphatase that consists of several isoforms, is present on all differentiated hematopoietic cells except erythrocytes and plasma cells and is essential for T cell development and lymphocyte activation. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
| Previous: | anti-CD30 monoclonal antibody MDX-1401, anti-CD30 monoclonal antibody XmAb2513, anti-CD33 monoclonal antibody-DM4 conjugate AVE9633, anti-CD37 single-chain polypeptide TRU-016, anti-CD38 monoclonal antibody | | Next: | anti-CD45 monoclonal antibody AHN-12, anti-CD70 monoclonal antibody MDX-1411, anti-CEA IgCD28TCR-transduced autologous T cells, anti-CEA/anti-DTPA-In (F6-734) bispecific antibody, anti-CS1 monoclonal antibody HuLuc63 |
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