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alpha-galactosylceramide-pulsed autologous dendritic cells A cancer vaccine comprised of autologous dendritic cells (DCs) pulsed with the marine sponge glycolipid alpha-galactosylceramide (alpha-GalCer) with potential immunostimulatory and antimetastatic activities. Upon administration, alpha-galactosylceramide-pulsed autologous dendritic cells may result in the activation and proliferation of a subset of endogenous natural killer T ( NKT) cells, B cells, and CD4+ and CD8+ T cells, and the production of interferon-gamma and interleukin-12; these cascade events may result in a T helper-1 cell-biased proinflammatory antitumor immune response. The NKT cell ligand alpha-GalCer was originally isolated from the marine sponge Agelas mauritianusis. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
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Synonym: | ![](https://webarchive.library.unt.edu/eot2008/20090509151012im_/http://www.cancer.gov/images/spacer.gif) | KRN7000-pulsed autologous dendritic cells | | ![](https://webarchive.library.unt.edu/eot2008/20090509151012im_/http://www.cancer.gov/images/spacer.gif) | Abbreviation: | ![](https://webarchive.library.unt.edu/eot2008/20090509151012im_/http://www.cancer.gov/images/spacer.gif) | DC-KRN7000 | | ![](https://webarchive.library.unt.edu/eot2008/20090509151012im_/http://www.cancer.gov/images/spacer.gif) |
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