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aerosolized liposomal 9-nitro-20 (S) camptothecin An aerosolized liposomal preparation of a water-insoluble derivative of camptothecin with potential antineoplastic activity. 9-nitro-20 (S)-camptothecin and its active metabolite 9-aminocamptothecin (9-AC) selectively stabilize topoisomerase I-DNA covalent complexes during S-phase, thereby inhibiting religation of topoisomerase I-mediated single-strand DNA breaks and producing potentially lethal double-strand DNA breaks when encountered by the DNA replication machinery.
This agent is formulated with dilauroylphosphatidylcholine and nebulized in particle sizes of 1.2-1.6 micrometer mass median aerodynamic diameter. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
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Synonym: | ![](https://webarchive.library.unt.edu/eot2008/20090511150604im_/http://www.cancer.gov/images/spacer.gif) | aerosolized liposomal 9-nitrocamptothecin | | ![](https://webarchive.library.unt.edu/eot2008/20090511150604im_/http://www.cancer.gov/images/spacer.gif) | Code name: | ![](https://webarchive.library.unt.edu/eot2008/20090511150604im_/http://www.cancer.gov/images/spacer.gif) | L9NC | | ![](https://webarchive.library.unt.edu/eot2008/20090511150604im_/http://www.cancer.gov/images/spacer.gif) |
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