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isotretinoin A naturally-occurring retinoic acid with potential antineoplastic activity. Isotretinoin binds to and activates nuclear retinoic acid receptors (RARs); activated RARs serve as transcription factors that promote cell differentiation and apoptosis. This agent also exhibits immunomodulatory and anti-inflammatory responses and inhibits ornithine decarboxylase, thereby decreasing polyamine synthesis and keratinization. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
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Synonyms: | ![](https://webarchive.library.unt.edu/eot2008/20090509151055im_/http://www.cancer.gov/images/spacer.gif) | 13-cis-retinoic acid 13-cis-vitamin A acid cis-retinoic acid isotretinoinum neovitamin A Neovitamin A Acid | | ![](https://webarchive.library.unt.edu/eot2008/20090509151055im_/http://www.cancer.gov/images/spacer.gif) | US brand names: | ![](https://webarchive.library.unt.edu/eot2008/20090509151055im_/http://www.cancer.gov/images/spacer.gif) | Accutane Amnesteem Cistane Claravis Sotret | | ![](https://webarchive.library.unt.edu/eot2008/20090509151055im_/http://www.cancer.gov/images/spacer.gif) | Foreign brand names: | ![](https://webarchive.library.unt.edu/eot2008/20090509151055im_/http://www.cancer.gov/images/spacer.gif) | Accure Isotrex Isotrexin Oratane Roaccutan Roaccutane Roacutan | | ![](https://webarchive.library.unt.edu/eot2008/20090509151055im_/http://www.cancer.gov/images/spacer.gif) | Abbreviation: | ![](https://webarchive.library.unt.edu/eot2008/20090509151055im_/http://www.cancer.gov/images/spacer.gif) | 13-CRA | | ![](https://webarchive.library.unt.edu/eot2008/20090509151055im_/http://www.cancer.gov/images/spacer.gif) | Code name: | ![](https://webarchive.library.unt.edu/eot2008/20090509151055im_/http://www.cancer.gov/images/spacer.gif) | Ro 4-3780 | | ![](https://webarchive.library.unt.edu/eot2008/20090509151055im_/http://www.cancer.gov/images/spacer.gif) | Chemical structure names: | ![](https://webarchive.library.unt.edu/eot2008/20090509151055im_/http://www.cancer.gov/images/spacer.gif) | - 3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)2-cis-4-trans-6-trans-8-trans-nonatetraenoic Acid
- 3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexene-1-yl)2cis-4-trans-6-trans-8-trans-nonatetraenoic Acid
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