![](https://webarchive.library.unt.edu/eot2008/20090511122751im_/http://www.cancer.gov/images/spacer.gif) |
|
![](https://webarchive.library.unt.edu/eot2008/20090511122751im_/http://www.cancer.gov/images/spacer.gif)
adenoviral vector encoding HSV thymidine kinase An adenoviral vector engineered to express the herpes simplex virus thymidine kinase (HSV-tk) gene, which, when administered in conjunction with a synthetic acyclic guanosine analogue, possesses potential antineoplastic activity. Adenoviral vector encoding HSV thymidine kinase is transduced into tumor cells, sensitizing tumor cells that overexpress HSV-tk to synthetic acyclic guanosine analogues. Subsequently, a low dose of a synthetic acyclic guanosine analogue such as valacyclovir (VCV) or ganciclovir (GCV) is given, which may preferentially kill tumor cells containing the adenoviral vector and overexpressing HSV-tk. Release of tumor-associated antigens (TAAs) by dying tumor cells may then stimulate an antitumor cytotoxic T lymphocyte (CTL) response. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
![](https://webarchive.library.unt.edu/eot2008/20090511122751im_/http://www.cancer.gov/images/spacer.gif)
Synonym: | ![](https://webarchive.library.unt.edu/eot2008/20090511122751im_/http://www.cancer.gov/images/spacer.gif) | adenoviral vector encoding herpes simplex virus thymidine kinase | | ![](https://webarchive.library.unt.edu/eot2008/20090511122751im_/http://www.cancer.gov/images/spacer.gif) | Abbreviations: | ![](https://webarchive.library.unt.edu/eot2008/20090511122751im_/http://www.cancer.gov/images/spacer.gif) | Ad HSV-tk adeno-HSV-tk ADV-tk | | ![](https://webarchive.library.unt.edu/eot2008/20090511122751im_/http://www.cancer.gov/images/spacer.gif) |
Previous: | Adanon, Adderall, Adderall XR, adefovir dipivoxil, adenovector encoding MDA7 | Next: | adenovirus 5-tumor necrosis factor alpha, adenovirus B7-1, adenovirus encoding human aquaporin-1, adenovirus encoding recombinant human endostatin, adenovirus HER2-transduced autologous dendritic cell vaccine |
|
![](https://webarchive.library.unt.edu/eot2008/20090511122751im_/http://www.cancer.gov/images/spacer.gif) |