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ABT-751 An orally bioavailable antimitotic sulfonamide. ABT-751 binds to the colchicine-binding site on beta-tubulin and inhibits the polymerization of microtubules, thereby preventing tumor cell replication. This agent also disrupts tumor neovascularization, reducing tumor blood flow and so inducing a cytotoxic effect. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
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Code name: | ![](https://webarchive.library.unt.edu/eot2008/20090509150830im_/http://www.cancer.gov/images/spacer.gif) | E7010 | | ![](https://webarchive.library.unt.edu/eot2008/20090509150830im_/http://www.cancer.gov/images/spacer.gif) | Chemical structure name: | ![](https://webarchive.library.unt.edu/eot2008/20090509150830im_/http://www.cancer.gov/images/spacer.gif) | N-[2-[(4-Hydroxyphenyl)amino]-3-pyridinyl]-4-methoxybenzenesulfonamide | | ![](https://webarchive.library.unt.edu/eot2008/20090509150830im_/http://www.cancer.gov/images/spacer.gif) |
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