![Study Results & Research Projects Study Results & Research Projects](https://webarchive.library.unt.edu/eot2008/20090511140534im_/http://ntp-server.niehs.nih.gov/images/template/subMastHead_studyResults.gif)
Pathology Tables for Peer Review
Pathology Tables for Peer Review
Home » Study Results & Research Projects » Pathology Tables for Peer Review » The National Toxicology Program
NTP Experiment-Test: 92013-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 01/12/04 Route: DOSED FEED Time: 14:42:16 FINAL #1 MICE Facility: Southern Research Institute Chemical CAS #: 822-36-6 Lock Date: 09/13/02 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All Page 1 NTP Experiment-Test: 92013-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 01/12/04 Route: DOSED FEED Time: 14:42:16 _____________________________________________________________________________________________________________________ | 5| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| DAY ON TEST | 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| | 9| 4| 4| 0| 4| 5| 5| 5| 5| 5| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 6| 3| 6| 6| 6| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Gallbladder | + + + + + A + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| Edema | 2 | |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Lymphoid | 4 3 | |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Lymphoid | | |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Basophilic Focus | X | Cyst | 3 | Eosinophilic Focus | | Hematopoietic Cell Proliferation | 4 3 1 2 | Hyperplasia, Lymphoid | 2 2 | Infiltration Cellular, Mixed Cell | | Mixed Cell Focus | | Necrosis, Focal | 4 2 | Centrilobular, Necrosis | | Hepatocyte, Hypertrophy | | Hepatocyte, Vacuolization Cytoplasmic| | Kupffer Cell, Pigmentation | 2 | |__________________________________________________________________________| Mesentery | + + | Fat, Necrosis | 4 2 | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 2 NTP Experiment-Test: 92013-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 01/12/04 Route: DOSED FEED Time: 14:42:16 _____________________________________________________________________________________________________________________ | 5| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| DAY ON TEST | 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| | 9| 4| 4| 0| 4| 5| 5| 5| 5| 5| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 6| 3| 6| 6| 6| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | Cyst | | Necrosis | 3 | Acinus, Cytoplasmic Alteration | 3 | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Lymphoid | | |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Diverticulum | X X | Ulcer | 2 | Epithelium, Hyperplasia | 2 2 | |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Tongue | + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Accessory Adrenal Cortical Nodule | X X X X X X | Hyperplasia, Diffuse | | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 | |__________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + M + + + + + + + + + + +| Pars Distalis, Cyst | | Pars Distalis, Hyperplasia, Focal | 3 | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 3 NTP Experiment-Test: 92013-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 01/12/04 Route: DOSED FEED Time: 14:42:16 _____________________________________________________________________________________________________________________ | 5| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| DAY ON TEST | 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| | 9| 4| 4| 0| 4| 5| 5| 5| 5| 5| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 6| 3| 6| 6| 6| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ENDOCRINE SYSTEM - cont | | Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Follicle, Cyst | 3 2 1 1 1 3 2| Follicular Cell, Hyperplasia | 2 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic | | |__________________________________________________________________________| Ovary | + + + + + + + + + I + + + + + + + + + + M + + + +| Angiectasis | 2 2 3 | Cyst | 3 3 3 3 3 3 | Granulosa Cell, Hyperplasia | | |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Cystic | 2 4 4 4 3 3 3 3 4 2 4 3 3 3 3 3 3 4 4 3 1 4 3 3| Inflammation, Chronic | | Metaplasia, Squamous | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 4 4 3 | |__________________________________________________________________________| Lymph Node | + + | |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 2 | Hyperplasia, Lymphoid | 2 2 3 2 | Pigmentation | 2 2 3 2 2 | |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Ectasia | 4 | Hematopoietic Cell Proliferation | 1 | Hyperplasia, Lymphoid | 2| __________________________________________|__________________________________________________________________________| Page 4 NTP Experiment-Test: 92013-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 01/12/04 Route: DOSED FEED Time: 14:42:16 _____________________________________________________________________________________________________________________ | 5| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| DAY ON TEST | 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| | 9| 4| 4| 0| 4| 5| 5| 5| 5| 5| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 6| 3| 6| 6| 6| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 4 2 1 3 4 2 2 | Hyperplasia, Lymphoid | 4 3 3 4 4| Lymphoid Follicle, Atrophy | | Lymphoid Follicle, Hyperplasia | 2 2 2 2 2 2 3 | |__________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 3 | Hyperplasia, Lymphoid | 2 3 | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 1 1 1 1 1 1 1 | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Subcutaneous Tissue, Inflammation, | | Granulomatous | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperostosis | 3 3 3 2 | |__________________________________________________________________________| Skeletal Muscle | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 1 | Hyperplasia, Lymphoid | 3 1 1 | Infiltration Cellular, Histiocyte | | Metaplasia, Osseous | | __________________________________________|__________________________________________________________________________| Page 5 NTP Experiment-Test: 92013-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 01/12/04 Route: DOSED FEED Time: 14:42:16 _____________________________________________________________________________________________________________________ | 5| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| DAY ON TEST | 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| | 9| 4| 4| 0| 4| 5| 5| 5| 5| 5| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 6| 3| 6| 6| 6| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| RESPIRATORY SYSTEM - cont | | Alveolar Epithelium, Hyperplasia | 1 | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic | | |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal | 2 | Inflammation, Chronic | 3 | |__________________________________________________________________________| Zymbal's Gland | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 3 | Hyperplasia, Lymphoid | 2 | Metaplasia, Osseous | 3 | Nephropathy | 1 1 1 1 2 2 1 3 1 1 | Renal Tubule, Accumulation, Hyaline | | Droplet | 3 | Renal Tubule, Hyperplasia | | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Lymphoid | | Inflammation, Chronic | | __________________________________________|__________________________________________________________________________ Page 6 NTP Experiment-Test: 92013-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 01/12/04 Route: DOSED FEED Time: 14:42:16 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 0| 3| 3| 3| 3| 3| 0| 3| 3| 3| | | 6| 6| 6| 6| 6| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 4| 4| 4| 4| 4| 6| 9| 4| 4| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Gallbladder | + + + + + + + + + I + A + + + + + + + + + + + + +| 47 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + A + + + + + + + M + + + + +| 48 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + A + + + + + + + + + + + + +| 49 | Edema | 2 2 | 3 2.0| |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + A + + + + + + + + M + + + +| 48 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia, Lymphoid | 3 3 | 4 3.3| |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + A + + + + + + + + + A + + +| 48 | Hyperplasia, Lymphoid | 4 | 1 4.0| |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Basophilic Focus | | 1 | Cyst | 3 3 | 3 3.0| Eosinophilic Focus | X | 1 | Hematopoietic Cell Proliferation | 3 3 | 6 2.7| Hyperplasia, Lymphoid | | 2 2.0| Infiltration Cellular, Mixed Cell | 4 | 1 4.0| Mixed Cell Focus | X | 1 | Necrosis, Focal | 3 4 | 4 3.3| Centrilobular, Necrosis | 2 | 1 2.0| Hepatocyte, Hypertrophy | 3 | 1 3.0| Hepatocyte, Vacuolization Cytoplasmic| 3 | 1 3.0| Kupffer Cell, Pigmentation | | 1 2.0| |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 7 NTP Experiment-Test: 92013-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 01/12/04 Route: DOSED FEED Time: 14:42:16 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 0| 3| 3| 3| 3| 3| 0| 3| 3| 3| | | 6| 6| 6| 6| 6| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 4| 4| 4| 4| 4| 6| 9| 4| 4| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | Mesentery | + | 3 | Fat, Necrosis | 2 | 3 2.7| |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + A + + + + + + + + + + + + +| 49 | Cyst | 3 3 3 | 3 3.0| Necrosis | | 1 3.0| Acinus, Cytoplasmic Alteration | | 1 3.0| |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia, Lymphoid | 3 2 3 | 3 2.7| |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Diverticulum | | 2 | Ulcer | | 1 2.0| Epithelium, Hyperplasia | 2 | 3 2.0| |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + A + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Tongue | + + | 3 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Accessory Adrenal Cortical Nodule | X X X | 9 | Hyperplasia, Diffuse | 3 | 1 3.0| |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + A + + + + + + + + + + + + +| 49 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 8 NTP Experiment-Test: 92013-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 01/12/04 Route: DOSED FEED Time: 14:42:16 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 0| 3| 3| 3| 3| 3| 0| 3| 3| 3| | | 6| 6| 6| 6| 6| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 4| 4| 4| 4| 4| 6| 9| 4| 4| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | Hyperplasia | | 1 2.0| |__________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + M + +| 49 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Pars Distalis, Cyst | 3 | 1 3.0| Pars Distalis, Hyperplasia, Focal | 3 | 2 3.0| |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Follicle, Cyst | 2 1 1 1 3 1 1 2 1 1 2 2 1| 20 1.6| Follicular Cell, Hyperplasia | | 1 2.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic | 2 | 1 2.0| |__________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Angiectasis | 2 2 2 2 4 3 | 9 2.4| Cyst | 3 3 X 3 3 3 3 3 3 3| 16 3.0| Granulosa Cell, Hyperplasia | 2 | 1 2.0| |__________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia, Cystic | 3 3 2 2 4 3 3 3 4 4 4 4 3 2 3 2 4 4 3 4 3| 45 3.2| Inflammation, Chronic | 2 | 1 2.0| Metaplasia, Squamous | 2 3 | 2 2.5| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 3 2 2 2 3 2 3 4 4 | 13 2.9| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 9 NTP Experiment-Test: 92013-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 01/12/04 Route: DOSED FEED Time: 14:42:16 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 0| 3| 3| 3| 3| 3| 0| 3| 3| 3| | | 6| 6| 6| 6| 6| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 4| 4| 4| 4| 4| 6| 9| 4| 4| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | |__________________________________________________________________________|____________| Lymph Node | + | 3 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + I + + + + + + + + I + I +| 47 | Hematopoietic Cell Proliferation | | 1 2.0| Hyperplasia, Lymphoid | 2 4 | 6 2.5| Pigmentation | 3 3 3 2 2 2 3| 12 2.4| |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + A + + + + + + + + + + + + +| 49 | Ectasia | | 1 4.0| Hematopoietic Cell Proliferation | 3 | 2 2.0| Hyperplasia, Lymphoid | 2 4 | 3 2.7| |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + A + + + + + + + + + + + + +| 49 | Hematopoietic Cell Proliferation | 3 1 2 4 3 3 4 4 | 15 2.8| Hyperplasia, Lymphoid | 2 4 4 | 8 3.5| Lymphoid Follicle, Atrophy | 3 | 1 3.0| Lymphoid Follicle, Hyperplasia | 2 3 3 2 2 3 2 | 14 2.3| |__________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + I + + + + + + + + + + + +| 49 | Atrophy | 3 3 | 3 3.0| Hyperplasia, Lymphoid | 2 | 3 2.3| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 1 1 1 1 1 1 1 2 1 | 16 1.1| |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Subcutaneous Tissue, Inflammation, | | | Granulomatous | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 10 NTP Experiment-Test: 92013-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 01/12/04 Route: DOSED FEED Time: 14:42:16 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 0| 3| 3| 3| 3| 3| 0| 3| 3| 3| | | 6| 6| 6| 6| 6| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 4| 4| 4| 4| 4| 6| 9| 4| 4| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| MUSCULOSKELETAL SYSTEM - cont | | | Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperostosis | 2 2 3 2 2 3| 10 2.5| |__________________________________________________________________________|____________| Skeletal Muscle | + | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemorrhage | | 1 1.0| Hyperplasia, Lymphoid | 1 3 2 | 6 1.8| Infiltration Cellular, Histiocyte | 1 | 1 1.0| Metaplasia, Osseous | 1 | 1 1.0| Alveolar Epithelium, Hyperplasia | 2 2 | 3 1.7| |__________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic | 3 | 1 3.0| |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia, Focal | 2 | 2 2.0| Inflammation, Chronic | | 1 3.0| |__________________________________________________________________________|____________| Zymbal's Gland | + | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 11 NTP Experiment-Test: 92013-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 01/12/04 Route: DOSED FEED Time: 14:42:16 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 0| 3| 3| 3| 3| 3| 0| 3| 3| 3| | | 6| 6| 6| 6| 6| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 4| 4| 4| 4| 4| 6| 9| 4| 4| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| URINARY SYSTEM - cont | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + A + + + + + + + + + + + + +| 49 | Cyst | | 1 3.0| Hyperplasia, Lymphoid | | 1 2.0| Metaplasia, Osseous | | 1 3.0| Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 | 21 1.2| Renal Tubule, Accumulation, Hyaline | | | Droplet | 3 2 | 3 2.7| Renal Tubule, Hyperplasia | 2 | 1 2.0| |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia, Lymphoid | 3 | 1 3.0| Inflammation, Chronic | 2 | 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 12 NTP Experiment-Test: 92013-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 01/12/04 Route: DOSED FEED Time: 14:42:16 _____________________________________________________________________________________________________________________ | 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| | 4| 4| 4| 5| 4| 5| 5| 5| 5| 5| 5| 5| 9| 5| 5| 4| 4| 8| 4| 4| 4| 4| 4| 4| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 312 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| Edema | 2 2 2 | |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Lymphoid | 3 | |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + M + + + + + + + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Eosinophilic Focus | | Hyperplasia, Lymphoid | 3 2 4 | Infiltration Cellular, Mixed Cell | 2 | Necrosis, Focal | 2 1 | Hepatocyte, Vacuolization Cytoplasmic| | Kupffer Cell, Pigmentation | | |__________________________________________________________________________| Mesentery | + + | Fat, Necrosis | 4 | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 4 | Cyst | 3 | Hyperplasia, Lymphoid | | Acinus, Cytoplasmic Alteration | | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + M + + + + + + + + + + + +| Hyperplasia, Lymphoid | 3 3 2 | __________________________________________|__________________________________________________________________________| Page 13 NTP Experiment-Test: 92013-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 01/12/04 Route: DOSED FEED Time: 14:42:16 _____________________________________________________________________________________________________________________ | 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| | 4| 4| 4| 5| 4| 5| 5| 5| 5| 5| 5| 5| 9| 5| 5| 4| 4| 8| 4| 4| 4| 4| 4| 4| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 312 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Ulcer | | Epithelium, Hyperplasia | 3 4 | |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Tongue | + | |__________________________________________________________________________| Tooth | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | | |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Myocardium, Necrosis | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Accessory Adrenal Cortical Nodule | X X X X X| Capsule, Hyperplasia | 2 2 | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | | |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + M + + + + + + + + + + +| Pars Distalis, Cyst | 3 3 3| Pars Distalis, Hyperplasia, Focal | 2 1 | |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Follicle, Cyst | 1 2 2 2 2 1 2 1 1 1 3 1 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | __________________________________________|__________________________________________________________________________| Page 14 NTP Experiment-Test: 92013-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 01/12/04 Route: DOSED FEED Time: 14:42:16 _____________________________________________________________________________________________________________________ | 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| | 4| 4| 4| 5| 4| 5| 5| 5| 5| 5| 5| 5| 9| 5| 5| 4| 4| 8| 4| 4| 4| 4| 4| 4| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 312 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic | | |__________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 2 2 2 3 3 3 2 | Cyst | 3 3 3 3 3 3 3 3 3 3 3 3 | Inflammation, Granulomatous | | Granulosa Cell, Hyperplasia | | |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 2 | Hyperplasia, Cystic | 3 2 2 3 3 4 3 2 4 2 4 4 3 2 4 3 3 2 3 4 3 3 4 4| Inflammation, Chronic | | Metaplasia, Squamous | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 2 2 3 3 2 | Infiltration Cellular, Mast Cell | 3 | |__________________________________________________________________________| Lymph Node | + + + | Iliac, Hemorrhage | 3 | Iliac, Hyperplasia, Lymphoid | | Inguinal, Hyperplasia, Lymphoid | | Mediastinal, Hyperplasia, Lymphoid | | |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + M + + + + + + + + + + + +| Hyperplasia, Lymphoid | 2 | Pigmentation | 2 2 2 2 2 2 2 2 3 3 2 2 2| |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + M + + + + + + + + + + + +| Atrophy | 2 | Hematopoietic Cell Proliferation | 3 | Hyperplasia, Lymphoid | 3 2 | |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 15 NTP Experiment-Test: 92013-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 01/12/04 Route: DOSED FEED Time: 14:42:16 _____________________________________________________________________________________________________________________ | 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| | 4| 4| 4| 5| 4| 5| 5| 5| 5| 5| 5| 5| 9| 5| 5| 4| 4| 8| 4| 4| 4| 4| 4| 4| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 312 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | Hematopoietic Cell Proliferation | 2 4 2 3 2 4 1 1 | Hyperplasia, Lymphoid | 4 3 4 2 4 | Pigmentation | | Lymphoid Follicle, Atrophy | | Lymphoid Follicle, Hyperplasia | 3 2 2 2 3| |__________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 3 3 | Hyperplasia, Lymphoid | 3 | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 1 1 1 1 2 1 | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Epidermis, Hyperplasia | 1 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperostosis | 2 2 2 2 2 3| |__________________________________________________________________________| Skeletal Muscle | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | | |__________________________________________________________________________| Peripheral Nerve | + | |__________________________________________________________________________| Spinal Cord | + | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 1 | __________________________________________|__________________________________________________________________________| Page 16 NTP Experiment-Test: 92013-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 01/12/04 Route: DOSED FEED Time: 14:42:16 _____________________________________________________________________________________________________________________ | 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| | 4| 4| 4| 5| 4| 5| 5| 5| 5| 5| 5| 5| 9| 5| 5| 4| 4| 8| 4| 4| 4| 4| 4| 4| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 312 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| RESPIRATORY SYSTEM - cont | | Hyperplasia, Lymphoid | 2 2 2 | Infiltration Cellular, Histiocyte | 2 1 | Alveolar Epithelium, Hyperplasia | 1 4 | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + M + + + + + + + + + + +| |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal | | Hyperplasia | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 3 | Hydronephrosis | | Hyperplasia, Lymphoid | 3 | Metaplasia, Osseous | 2 | Nephropathy | 2 1 1 1 1 1 1 1 1 2 1| Renal Tubule, Accumulation, Hyaline | | Droplet | 4 3 | Renal Tubule, Necrosis | | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | | Hyperplasia, Lymphoid | 2 | Inflammation, Chronic | | __________________________________________|__________________________________________________________________________ Page 17 NTP Experiment-Test: 92013-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 01/12/04 Route: DOSED FEED Time: 14:42:16 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 6| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 9| 5| 3| 2| 3| 3| 3| 3| 2| 0| 3| 3| 0| 3| 3| 3| 3| | | 6| 6| 6| 6| 6| 2| 5| 5| 7| 6| 5| 7| 5| 5| 5| 6| 1| 2| 6| 6| 5| 7| 7| 7| 7| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A | 312 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Gallbladder | + + + + + A + + A + + A + + + + + + + + + + + + +| 47 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + I + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + A + + + + + A + + + + + + + + + + + + +| 48 | Edema | 2 | 4 2.0| |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + I + + A + + A + + + + + + + + + + + + +| 47 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + A + + A + + + + + + + + + + + + +| 48 | Hyperplasia, Lymphoid | 4 | 2 3.5| |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + A + + A + + A + + + + + + + + A + + + +| 45 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Eosinophilic Focus | X X | 2 | Hyperplasia, Lymphoid | | 3 3.0| Infiltration Cellular, Mixed Cell | 3 1 | 3 2.0| Necrosis, Focal | 1 | 3 1.3| Hepatocyte, Vacuolization Cytoplasmic| 3 | 1 3.0| Kupffer Cell, Pigmentation | 2 | 1 2.0| |__________________________________________________________________________|____________| Mesentery | + + + + + | 7 | Fat, Necrosis | 2 3 | 3 3.0| |__________________________________________________________________________|____________| Pancreas | + + + + + A + + + + + M + + + + + + + + + + + + +| 48 | Atrophy | | 1 4.0| Cyst | | 1 3.0| Hyperplasia, Lymphoid | 2 | 1 2.0| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 18 NTP Experiment-Test: 92013-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 01/12/04 Route: DOSED FEED Time: 14:42:16 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 6| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 9| 5| 3| 2| 3| 3| 3| 3| 2| 0| 3| 3| 0| 3| 3| 3| 3| | | 6| 6| 6| 6| 6| 2| 5| 5| 7| 6| 5| 7| 5| 5| 5| 6| 1| 2| 6| 6| 5| 7| 7| 7| 7| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A | 312 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | Acinus, Cytoplasmic Alteration | 3 | 1 3.0| |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + A + + + + + + + + + + + + +| 48 | Hyperplasia, Lymphoid | 2 | 4 2.5| |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Ulcer | 3 | 1 3.0| Epithelium, Hyperplasia | 2 3 1 | 5 2.6| |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + A + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Tongue | + + | 3 | |__________________________________________________________________________|____________| Tooth | + | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | + | 1 | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Myocardium, Necrosis | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Accessory Adrenal Cortical Nodule | X X X X | 9 | Capsule, Hyperplasia | | 2 2.0| |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + A + + + + + M + + + + + + + + + + + + +| 48 | |__________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + M + + + + + + + + + + + + +| 49 | Cyst | 3 | 1 3.0| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 19 NTP Experiment-Test: 92013-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 01/12/04 Route: DOSED FEED Time: 14:42:16 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 6| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 9| 5| 3| 2| 3| 3| 3| 3| 2| 0| 3| 3| 0| 3| 3| 3| 3| | | 6| 6| 6| 6| 6| 2| 5| 5| 7| 6| 5| 7| 5| 5| 5| 6| 1| 2| 6| 6| 5| 7| 7| 7| 7| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A | 312 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + M M + + + + + + + + + + M + + + + + + +| 46 | Pars Distalis, Cyst | | 3 3.0| Pars Distalis, Hyperplasia, Focal | 2 3 | 4 2.0| |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + M + + + + + + + + + + + + +| 49 | Follicle, Cyst | 2 2 3 1 1 1 2 2 3 1 | 22 1.7| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + + M + + + + + + + + + + + + +| 49 | Inflammation, Chronic | 2 2 2| 3 2.0| |__________________________________________________________________________|____________| Ovary | + + + M + + + + + + + + + + + + + + + + + + + + +| 49 | Angiectasis | 3 2 | 9 2.4| Cyst | 3 3 3 3 3 3 3 3 | 20 3.0| Inflammation, Granulomatous | 3 | 1 3.0| Granulosa Cell, Hyperplasia | 3 | 1 3.0| |__________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | 3 2 | 3 2.3| Hyperplasia, Cystic | 4 4 4 2 4 4 3 4 2 4 4 3 3 4 2 2 2 4 3 4 3 4 4| 47 3.2| Inflammation, Chronic | 3 | 1 3.0| Metaplasia, Squamous | 2 4 2| 3 2.7| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 3 4 3 3 3 2 2 | 13 2.6| Infiltration Cellular, Mast Cell | | 1 3.0| |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 20 NTP Experiment-Test: 92013-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 01/12/04 Route: DOSED FEED Time: 14:42:16 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 6| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 9| 5| 3| 2| 3| 3| 3| 3| 2| 0| 3| 3| 0| 3| 3| 3| 3| | | 6| 6| 6| 6| 6| 2| 5| 5| 7| 6| 5| 7| 5| 5| 5| 6| 1| 2| 6| 6| 5| 7| 7| 7| 7| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A | 312 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | Lymph Node | + + + + + + | 9 | Iliac, Hemorrhage | | 1 3.0| Iliac, Hyperplasia, Lymphoid | 2 3 | 2 2.5| Inguinal, Hyperplasia, Lymphoid | 2 3 | 2 2.5| Mediastinal, Hyperplasia, Lymphoid | 2 3 | 2 2.5| |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + M + + + + M + + + + + + + +| 47 | Hyperplasia, Lymphoid | 2 3 2 3 2 2 2 | 8 2.3| Pigmentation | 3 2 2 2 3 2 | 19 2.2| |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + A + + + + + M + + + + + + + + + + + + +| 47 | Atrophy | 3 | 2 2.5| Hematopoietic Cell Proliferation | | 1 3.0| Hyperplasia, Lymphoid | 2 3 2 2 2 2| 8 2.3| |__________________________________________________________________________|____________| Spleen | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 | Hematopoietic Cell Proliferation | 2 1 1 3 3 2 2 3 | 16 2.3| Hyperplasia, Lymphoid | 3 3 4 4 4 3 | 11 3.5| Pigmentation | 3 | 1 3.0| Lymphoid Follicle, Atrophy | 3 | 1 3.0| Lymphoid Follicle, Hyperplasia | 2 2 2 3 2 3 2| 12 2.3| |__________________________________________________________________________|____________| Thymus | + M + + + + + + + + + + + + + + + + + + + + + + +| 49 | Atrophy | 2 3 3 2 | 6 2.7| Hyperplasia, Lymphoid | | 1 3.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 1 1 1 1 | 10 1.1| |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Epidermis, Hyperplasia | | 1 1.0| _____________________________________________________________________________________________________________________| | * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 21 NTP Experiment-Test: 92013-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 01/12/04 Route: DOSED FEED Time: 14:42:16 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 6| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 9| 5| 3| 2| 3| 3| 3| 3| 2| 0| 3| 3| 0| 3| 3| 3| 3| | | 6| 6| 6| 6| 6| 2| 5| 5| 7| 6| 5| 7| 5| 5| 5| 6| 1| 2| 6| 6| 5| 7| 7| 7| 7| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A | 312 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperostosis | 2 3 3 2 2 1 | 12 2.2| |__________________________________________________________________________|____________| Skeletal Muscle | + | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemorrhage | 3 3 | 2 3.0| |__________________________________________________________________________|____________| Peripheral Nerve | + | 2 | |__________________________________________________________________________|____________| Spinal Cord | + | 2 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemorrhage | 2 | 2 1.5| Hyperplasia, Lymphoid | 2 2 3| 6 2.2| Infiltration Cellular, Histiocyte | 2 1 1 | 5 1.4| Alveolar Epithelium, Hyperplasia | | 2 2.5| |__________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia, Focal | 4 2 2 | 3 2.7| Hyperplasia | 3 | 1 3.0| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 22 NTP Experiment-Test: 92013-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 01/12/04 Route: DOSED FEED Time: 14:42:16 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 6| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 9| 5| 3| 2| 3| 3| 3| 3| 2| 0| 3| 3| 0| 3| 3| 3| 3| | | 6| 6| 6| 6| 6| 2| 5| 5| 7| 6| 5| 7| 5| 5| 5| 6| 1| 2| 6| 6| 5| 7| 7| 7| 7| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A | 312 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | | 1 3.0| Hydronephrosis | 2 | 1 2.0| Hyperplasia, Lymphoid | 3 | 2 3.0| Metaplasia, Osseous | | 1 2.0| Nephropathy | 1 1 4 1 1 1 2 1 1 | 20 1.3| Renal Tubule, Accumulation, Hyaline | | | Droplet | | 2 3.5| Renal Tubule, Necrosis | 2 | 1 2.0| |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemorrhage | 3 | 1 3.0| Hyperplasia, Lymphoid | 2 2 | 3 2.0| Inflammation, Chronic | 3 | 1 3.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 23 NTP Experiment-Test: 92013-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 01/12/04 Route: DOSED FEED Time: 14:42:16 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| DAY ON TEST | 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| | 7| 0| 7| 7| 7| 4| 4| 4| 4| 2| 5| 5| 5| 5| 5| 4| 4| 7| 4| 4| 5| 5| 5| 9| 5| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 625 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Gallbladder | + + + + + + + + + + + + + + + + + I + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | + A + + + + + + + A + + + + + + + + + + + + + + +| Edema | | |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + A + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + A + + + + + + + + + + + + + + + A + + + + + + +| Hyperplasia, Lymphoid | | |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + A + + + + + + + + + + + + + + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 3 2 | Basophilic Focus | | Eosinophilic Focus | | Hematopoietic Cell Proliferation | 4 4 4 3 | Hyperplasia, Lymphoid | | Infiltration Cellular, Mixed Cell | 3 | Mixed Cell Focus | | Necrosis, Focal | 3 | Centrilobular, Necrosis | | Hepatocyte, Vacuolization Cytoplasmic| | Kupffer Cell, Pigmentation | | |__________________________________________________________________________| Mesentery | + + + + | Fat, Necrosis | 4 3 2 | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + M + + + + + + +| |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 24 NTP Experiment-Test: 92013-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 01/12/04 Route: DOSED FEED Time: 14:42:16 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| DAY ON TEST | 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| | 7| 0| 7| 7| 7| 4| 4| 4| 4| 2| 5| 5| 5| 5| 5| 4| 4| 7| 4| 4| 5| 5| 5| 9| 5| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 625 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | Hyperplasia, Lymphoid | | |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Squamous | | Inflammation, Chronic | | Epithelium, Hyperplasia | 2 2 | |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Erosion | 2 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic | | Thrombosis | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Accessory Adrenal Cortical Nodule | X X X X | Hyperplasia, Focal | | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 | |__________________________________________________________________________| Islets, Pancreatic | + A + + + + + + + + + + + + + + + M + + + + + + +| |__________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + M + + + + + + +| Cyst | 3 3 3 3 3| |__________________________________________________________________________| Pituitary Gland | + M + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Cyst | 3 3 | Pars Distalis, Hyperplasia, Focal | 2 | |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Follicle, Cyst | 2 2 2 2 1 2 2 3 1 1 2 1 1 2| Follicular Cell, Hyperplasia | 4 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | __________________________________________|__________________________________________________________________________| Page 25 NTP Experiment-Test: 92013-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 01/12/04 Route: DOSED FEED Time: 14:42:16 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| DAY ON TEST | 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| | 7| 0| 7| 7| 7| 4| 4| 4| 4| 2| 5| 5| 5| 5| 5| 4| 4| 7| 4| 4| 5| 5| 5| 9| 5| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 625 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic | 2 | |__________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 3 3 2 3 | Cyst | 3 3 3 3 3 3 3 | Thecal Cell, Hyperplasia | | |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Cystic | 4 2 2 3 2 3 2 3 3 2 2 2 3 3 4 3 2 2 3 4 4 3 3| Inflammation, Chronic | 3 | Metaplasia, Squamous | 3 | Thrombosis | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 2 2 4 4 3 4 4 | |__________________________________________________________________________| Lymph Node | + + + + + +| Bronchial, Hyperplasia, Lymphoid | 2 | Iliac, Hyperplasia, Lymphoid | 3 | Inguinal, Hyperplasia, Lymphoid | 3 | Renal, Hematopoietic Cell | | Proliferation | 3 | Renal, Hyperplasia, Lymphoid | 2 | |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + M + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 3 | Hemorrhage | | Hyperplasia, Lymphoid | 3 2 4 2 2 | Pigmentation | 2 2 2 2 2 2 2 3 2 3 2 | |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Ectasia | 2 | Hematopoietic Cell Proliferation | 2 1 | Hyperplasia, Lymphoid | 2 2 3 3 2 2 | __________________________________________|__________________________________________________________________________| Page 26 NTP Experiment-Test: 92013-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 01/12/04 Route: DOSED FEED Time: 14:42:16 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| DAY ON TEST | 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| | 7| 0| 7| 7| 7| 4| 4| 4| 4| 2| 5| 5| 5| 5| 5| 4| 4| 7| 4| 4| 5| 5| 5| 9| 5| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 625 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | |__________________________________________________________________________| Spleen | + A + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 1 3 2 4 4 2 4 3 | Hyperplasia, Lymphoid | 4 3 4 4 3 | Pigmentation | 2 | Lymphoid Follicle, Hyperplasia | 2 2 2 3 3 2 | |__________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | | Hyperplasia, Lymphoid | 3 3 | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + M + + + + + + + + + + + + + + +| Hyperplasia | 1 1 1 1 1 2 1 1 1| |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Edema | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperostosis | 2 3 | |__________________________________________________________________________| Skeletal Muscle | + | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 2 | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 2 | Hyperplasia, Lymphoid | 1 2 2 2 | Infiltration Cellular, Histiocyte | | Alveolar Epithelium, Hyperplasia | 1 3 | __________________________________________|__________________________________________________________________________| Page 27 NTP Experiment-Test: 92013-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 01/12/04 Route: DOSED FEED Time: 14:42:16 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| DAY ON TEST | 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| | 7| 0| 7| 7| 7| 4| 4| 4| 4| 2| 5| 5| 5| 5| 5| 4| 4| 7| 4| 4| 5| 5| 5| 9| 5| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 625 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| RESPIRATORY SYSTEM - cont | | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| Cataract | 1 3 | Inflammation, Chronic | 2 | Cornea, Hyperplasia | 2 | Cornea, Mineralization | 1 | Retina, Degeneration | 2 | |__________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal | 2 2| |__________________________________________________________________________| Zymbal's Gland | + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Lymphoid | 2 3 2 2 | Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 1| Renal Tubule, Accumulation, Hyaline | | Droplet | 3 | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Edema | | Hyperplasia, Lymphoid | 2 2 | __________________________________________|__________________________________________________________________________ Page 28 NTP Experiment-Test: 92013-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 01/12/04 Route: DOSED FEED Time: 14:42:16 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 8| 3| 3| 3| | | 5| 5| 5| 5| 5| 6| 5| 1| 6| 6| 5| 5| 5| 5| 4| 5| 5| 5| 5| 5| 5| 4| 5| 5| 5| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 625 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Gallbladder | + + + + + + + + + + + + + + A + + + + + + + + + +| 48 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + M + + + + + + A + + + + + + + + + +| 46 | Edema | 2 2 | 2 2.0| |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + A + + + + + + + + + +| 47 | Hyperplasia, Lymphoid | 3 2 | 2 2.5| |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + A + + + + + + + + + +| 48 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | | 2 2.5| Basophilic Focus | X| 1 | Eosinophilic Focus | X | 1 | Hematopoietic Cell Proliferation | 2 | 5 3.4| Hyperplasia, Lymphoid | 4 | 1 4.0| Infiltration Cellular, Mixed Cell | | 1 3.0| Mixed Cell Focus | X | 1 | Necrosis, Focal | 1 | 2 2.0| Centrilobular, Necrosis | 3 | 1 3.0| Hepatocyte, Vacuolization Cytoplasmic| 3 | 1 3.0| Kupffer Cell, Pigmentation | 4 2 | 2 3.0| |__________________________________________________________________________|____________| Mesentery | + + + | 7 | Fat, Necrosis | | 3 3.0| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 29 NTP Experiment-Test: 92013-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 01/12/04 Route: DOSED FEED Time: 14:42:16 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 8| 3| 3| 3| | | 5| 5| 5| 5| 5| 6| 5| 1| 6| 6| 5| 5| 5| 5| 4| 5| 5| 5| 5| 5| 5| 4| 5| 5| 5| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 625 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + A + + + + + + + + + +| 48 | |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia, Lymphoid | 2 2 2 | 3 2.0| |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia, Squamous | 4 | 1 4.0| Inflammation, Chronic | 2 | 1 2.0| Epithelium, Hyperplasia | | 2 2.0| |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Erosion | 3 | 2 2.5| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic | 1 | 1 1.0| Thrombosis | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Accessory Adrenal Cortical Nodule | X X X X X | 9 | Hyperplasia, Focal | 1 | 1 1.0| |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | | 1 2.0| |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + A + + + + + + + + + +| 47 | |__________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + + M + + + + + + + + +| 48 | Cyst | | 5 3.0| |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 30 NTP Experiment-Test: 92013-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 01/12/04 Route: DOSED FEED Time: 14:42:16 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 8| 3| 3| 3| | | 5| 5| 5| 5| 5| 6| 5| 1| 6| 6| 5| 5| 5| 5| 4| 5| 5| 5| 5| 5| 5| 4| 5| 5| 5| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 625 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Pars Distalis, Cyst | 3 3 | 4 3.0| Pars Distalis, Hyperplasia, Focal | | 1 2.0| |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Follicle, Cyst | 2 1 3 2 2 1 1 1 3 2 2 2 2 2 2 | 29 1.8| Follicular Cell, Hyperplasia | | 1 4.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic | 2 2 4 2 | 5 2.4| |__________________________________________________________________________|____________| Ovary | + + I + + + + + + + + + + + + + + + + + + + + + +| 49 | Angiectasis | 3 3 3 | 7 2.9| Cyst | 3 3 3 3 3 3 3 | 14 3.0| Thecal Cell, Hyperplasia | 3 | 1 3.0| |__________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia, Cystic | 3 3 4 3 4 4 2 4 3 3 4 4 2 3 2 3 3 3 3 2 3 4 3| 46 3.0| Inflammation, Chronic | | 1 3.0| Metaplasia, Squamous | | 1 3.0| Thrombosis | 4 | 1 4.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 4 3 | 10 3.2| |__________________________________________________________________________|____________| Lymph Node | + + + + + +| 12 | Bronchial, Hyperplasia, Lymphoid | | 1 2.0| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 31 NTP Experiment-Test: 92013-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 01/12/04 Route: DOSED FEED Time: 14:42:16 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 8| 3| 3| 3| | | 5| 5| 5| 5| 5| 6| 5| 1| 6| 6| 5| 5| 5| 5| 4| 5| 5| 5| 5| 5| 5| 4| 5| 5| 5| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 625 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | Iliac, Hyperplasia, Lymphoid | | 1 3.0| Inguinal, Hyperplasia, Lymphoid | | 1 3.0| Renal, Hematopoietic Cell | | | Proliferation | | 1 3.0| Renal, Hyperplasia, Lymphoid | | 1 2.0| |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + M + + + + + + +| 48 | Hematopoietic Cell Proliferation | 2 | 2 2.5| Hemorrhage | 2 | 1 2.0| Hyperplasia, Lymphoid | 4 2 | 7 2.7| Pigmentation | 2 2 2 3 2 2 2| 18 2.2| |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 | Ectasia | | 1 2.0| Hematopoietic Cell Proliferation | | 2 1.5| Hyperplasia, Lymphoid | 4 3 2 | 9 2.6| |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hematopoietic Cell Proliferation | 3 4 3 3 1 | 13 2.8| Hyperplasia, Lymphoid | 4 4 4 | 8 3.8| Pigmentation | | 1 2.0| Lymphoid Follicle, Hyperplasia | 3 3 3 2 2 2 | 12 2.4| |__________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | 3 4 | 2 3.5| Hyperplasia, Lymphoid | | 2 3.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hyperplasia | 1 1 1 1 1 | 14 1.1| |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Edema | 2 | 1 2.0| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 32 NTP Experiment-Test: 92013-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 01/12/04 Route: DOSED FEED Time: 14:42:16 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 8| 3| 3| 3| | | 5| 5| 5| 5| 5| 6| 5| 1| 6| 6| 5| 5| 5| 5| 4| 5| 5| 5| 5| 5| 5| 4| 5| 5| 5| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 625 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperostosis | 2 2 2 2 2 3 3 3| 10 2.4| |__________________________________________________________________________|____________| Skeletal Muscle | + | 2 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemorrhage | | 1 2.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemorrhage | 2 1 | 3 1.7| Hyperplasia, Lymphoid | 2 1 2 2 | 8 1.8| Infiltration Cellular, Histiocyte | 1 | 1 1.0| Alveolar Epithelium, Hyperplasia | 1 | 3 1.7| |__________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cataract | | 2 2.0| Inflammation, Chronic | | 1 2.0| Cornea, Hyperplasia | | 1 2.0| Cornea, Mineralization | | 1 1.0| Retina, Degeneration | | 1 2.0| |__________________________________________________________________________|____________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia, Focal | | 2 2.0| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 33 NTP Experiment-Test: 92013-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 01/12/04 Route: DOSED FEED Time: 14:42:16 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 8| 3| 3| 3| | | 5| 5| 5| 5| 5| 6| 5| 1| 6| 6| 5| 5| 5| 5| 4| 5| 5| 5| 5| 5| 5| 4| 5| 5| 5| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 625 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| SPECIAL SENSES SYSTEM - cont | | | |__________________________________________________________________________|____________| Zymbal's Gland | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia, Lymphoid | 2 2 | 6 2.2| Nephropathy | 1 1 1 1 | 17 1.0| Renal Tubule, Accumulation, Hyaline | | | Droplet | | 1 3.0| |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Edema | 3 | 1 3.0| Hyperplasia, Lymphoid | 2 2 | 4 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 34 NTP Experiment-Test: 92013-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 01/12/04 Route: DOSED FEED Time: 14:42:16 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 3| 3| 3| 2| 4| 2| 2| 8| 5| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| | 4| 4| 4| 4| 4| 9| 0| 9| 9| 7| 2| 5| 5| 5| 5| 7| 7| 7| 7| 7| 5| 5| 5| 5| 5| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1250 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + A + + + M + + + + + + + + + + +| Edema | | |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + A + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + A + + + + + + + + + + + + + + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Basophilic Focus | | Cyst | 3 | Hematopoietic Cell Proliferation | 3 | Hemorrhage | 3 | Infiltration Cellular, Mixed Cell | 2 | Necrosis, Focal | 3 1 1 4 | Centrilobular, Necrosis | | Hepatocyte, Vacuolization Cytoplasmic| | |__________________________________________________________________________| Mesentery | | Hemorrhage | | Fat, Necrosis | | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Lymphoid | 2 | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + M + + + + +| Atrophy | | Hyperplasia, Lymphoid | 3 3 2 | __________________________________________|__________________________________________________________________________| Page 35 NTP Experiment-Test: 92013-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 01/12/04 Route: DOSED FEED Time: 14:42:16 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 3| 3| 3| 2| 4| 2| 2| 8| 5| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| | 4| 4| 4| 4| 4| 9| 0| 9| 9| 7| 2| 5| 5| 5| 5| 7| 7| 7| 7| 7| 5| 5| 5| 5| 5| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1250 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic | | Epithelium, Hyperplasia | | |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Erosion | | |__________________________________________________________________________| Tongue | + | |__________________________________________________________________________| Tooth | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization | 1 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Accessory Adrenal Cortical Nodule | X X | Hyperplasia, Focal | | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 3 | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 2 | |__________________________________________________________________________| Parathyroid Gland | + + + + + + + M + + + + + + + + + + + M + + M + +| Cyst | 3 | |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + M + + M + +| Follicle, Cyst | 1 1 3 2 3 3 2 2 2 2 2 3 1 2 3| Follicular Cell, Hyperplasia | 1 | __________________________________________|__________________________________________________________________________| Page 36 NTP Experiment-Test: 92013-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 01/12/04 Route: DOSED FEED Time: 14:42:16 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 3| 3| 3| 2| 4| 2| 2| 8| 5| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| | 4| 4| 4| 4| 4| 9| 0| 9| 9| 7| 2| 5| 5| 5| 5| 7| 7| 7| 7| 7| 5| 5| 5| 5| 5| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1250 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| GENERAL BODY SYSTEM | | |__________________________________________________________________________| Tissue NOS | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic | 3 | |__________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 2 2 3 2 | Cyst | 3 3 3 3 3 | Corpus Luteum, Hyperplasia | | |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 2 2 2| Hyperplasia, Cystic | 4 2 4 4 3 3 2 3 2 3 3 4 4 4 3 2 4 3 2 2 4 4 3 3| Inflammation, Chronic | 2 | Metaplasia, Squamous | 3 2 1 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 3 3 2 2 2 2 2 3 2 2 | |__________________________________________________________________________| Lymph Node | + + + + | Iliac, Hemorrhage | 2 | Iliac, Hyperplasia, Lymphoid | 3 | Iliac, Pigmentation | 3 | Renal, Hyperplasia, Lymphoid | 3 | Renal, Pigmentation | 3 | |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + M + + + + +| Hemorrhage | 1 3 | Hyperplasia, Lymphoid | 3 3 3 2 3 1 3 1 | Pigmentation | 2 2 3 2 2 2 2 2 2 | |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Lymphoid | 2 3 2 2 | __________________________________________|__________________________________________________________________________| Page 37 NTP Experiment-Test: 92013-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 01/12/04 Route: DOSED FEED Time: 14:42:16 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 3| 3| 3| 2| 4| 2| 2| 8| 5| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| | 4| 4| 4| 4| 4| 9| 0| 9| 9| 7| 2| 5| 5| 5| 5| 7| 7| 7| 7| 7| 5| 5| 5| 5| 5| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1250 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + A + + + + +| Hematopoietic Cell Proliferation | 1 2 2 2 2 2 | Hyperplasia, Lymphoid | 2 4 3 3 4 4 3 | Lymphoid Follicle, Atrophy | | Lymphoid Follicle, Hyperplasia | 2 2 2 3 2 3 2| Red Pulp, Congestion | | |__________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 2 | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + A + + + + + + + + + + + + + + +| Galactocele | X | Hyperplasia | 1 1 1 2 2 1 1 1 1 1 | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Edema | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperostosis | 2 2 2 3 2 2 | |__________________________________________________________________________| Skeletal Muscle | + + | Mineralization | 2 | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Compression | 4 | Hemorrhage | 2 | |__________________________________________________________________________| Peripheral Nerve | + + | Atrophy | 3 | |__________________________________________________________________________| Spinal Cord | + | __________________________________________|__________________________________________________________________________| Page 38 NTP Experiment-Test: 92013-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 01/12/04 Route: DOSED FEED Time: 14:42:16 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 3| 3| 3| 2| 4| 2| 2| 8| 5| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| | 4| 4| 4| 4| 4| 9| 0| 9| 9| 7| 2| 5| 5| 5| 5| 7| 7| 7| 7| 7| 5| 5| 5| 5| 5| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1250 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 2 | Hyperplasia, Lymphoid | 2 3 2 2 1 2 | Infiltration Cellular, Histiocyte | 2 1 3 1 3 2 | Alveolar Epithelium, Hyperplasia | 2 3 1 2 3 2 2| |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| Cataract | 2 | Inflammation, Chronic | 1 | |__________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Lymphoid | 2 | Metaplasia, Osseous | | Nephropathy | 1 1 1 1 1 2 1 1 1 1 1 1 | Renal Tubule, Accumulation, Hyaline | | Droplet | | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Edema | 4 | Hyperplasia, Lymphoid | 2 2 2 | __________________________________________|__________________________________________________________________________ Page 39 NTP Experiment-Test: 92013-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 01/12/04 Route: DOSED FEED Time: 14:42:16 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 7| 5| 7| 7| | DAY ON TEST | 6| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 1| 3| 8| 3| 2| 2| 2| 0| 2| 3| 3| 6| 3| 3| | | 5| 5| 5| 5| 7| 4| 4| 4| 4| 4| 6| 1| 6| 5| 6| 9| 9| 9| 9| 9| 3| 5| 9| 5| 5| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A | 1250 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Gallbladder | + + + + + + + + + + + + + + + + + + + + A + + + +| 49 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + A + + + +| 49 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + I + A + + + +| 48 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + A + + + + + + + + A + + + +| 46 | Edema | 2 2 | 2 2.0| |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + A + M + +| 48 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + A + + + + + + + + A + + + +| 47 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + A + + + +| 48 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Basophilic Focus | X | 1 | Cyst | | 1 3.0| Hematopoietic Cell Proliferation | 2 2 | 3 2.3| Hemorrhage | | 1 3.0| Infiltration Cellular, Mixed Cell | | 1 2.0| Necrosis, Focal | 3 4 | 6 2.7| Centrilobular, Necrosis | 4 | 1 4.0| Hepatocyte, Vacuolization Cytoplasmic| 4 | 1 4.0| |__________________________________________________________________________|____________| Mesentery | + + + + | 4 | Hemorrhage | 2 | 1 2.0| Fat, Necrosis | 2 3 3 | 3 2.7| |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + A + + + +| 49 | Hyperplasia, Lymphoid | | 1 2.0| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 40 NTP Experiment-Test: 92013-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 01/12/04 Route: DOSED FEED Time: 14:42:16 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 7| 5| 7| 7| | DAY ON TEST | 6| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 1| 3| 8| 3| 2| 2| 2| 0| 2| 3| 3| 6| 3| 3| | | 5| 5| 5| 5| 7| 4| 4| 4| 4| 4| 6| 1| 6| 5| 6| 9| 9| 9| 9| 9| 3| 5| 9| 5| 5| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A | 1250 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Atrophy | 2 2 | 2 2.0| Hyperplasia, Lymphoid | | 3 2.7| |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic | 2 | 1 2.0| Epithelium, Hyperplasia | 1 1 2 1 4 | 5 1.8| |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + A + + + +| 49 | Erosion | 1 | 1 1.0| |__________________________________________________________________________|____________| Tongue | + + | 3 | |__________________________________________________________________________|____________| Tooth | + | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mineralization | 2 2 3 | 4 2.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Accessory Adrenal Cortical Nodule | X X X | 5 | Hyperplasia, Focal | 3 2 | 2 2.5| |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 2 | 2 2.5| |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + A + + + +| 49 | Hyperplasia | | 2 2.0| |__________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 41 NTP Experiment-Test: 92013-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 01/12/04 Route: DOSED FEED Time: 14:42:16 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 7| 5| 7| 7| | DAY ON TEST | 6| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 1| 3| 8| 3| 2| 2| 2| 0| 2| 3| 3| 6| 3| 3| | | 5| 5| 5| 5| 7| 4| 4| 4| 4| 4| 6| 1| 6| 5| 6| 9| 9| 9| 9| 9| 3| 5| 9| 5| 5| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A | 1250 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | Cyst | 3 | 2 3.0| |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Follicle, Cyst | 3 3 2 2 2 1 3 1 3 2 1 2 2 2 1| 30 2.1| Follicular Cell, Hyperplasia | | 1 1.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | |__________________________________________________________________________|____________| Tissue NOS | + | 1 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic | 2 2 | 3 2.3| |__________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | 4 2 | 6 2.5| Cyst | 3 3 3 3 3 3 3 3 3 3 3 3 3 3 | 19 3.0| Corpus Luteum, Hyperplasia | 3 | 1 3.0| |__________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | | 3 2.0| Hyperplasia, Cystic | 1 4 4 3 4 1 3 3 3 4 4 3 3 3 3 2 4 3 4 4 4 3 3| 47 3.1| Inflammation, Chronic | 3 3 | 3 2.7| Metaplasia, Squamous | 3 2 | 5 2.2| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 2 2 3 2 3 3 2 | 17 2.4| |__________________________________________________________________________|____________| Lymph Node | + + + | 7 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 42 NTP Experiment-Test: 92013-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 01/12/04 Route: DOSED FEED Time: 14:42:16 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 7| 5| 7| 7| | DAY ON TEST | 6| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 1| 3| 8| 3| 2| 2| 2| 0| 2| 3| 3| 6| 3| 3| | | 5| 5| 5| 5| 7| 4| 4| 4| 4| 4| 6| 1| 6| 5| 6| 9| 9| 9| 9| 9| 3| 5| 9| 5| 5| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A | 1250 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | Iliac, Hemorrhage | | 1 2.0| Iliac, Hyperplasia, Lymphoid | | 1 3.0| Iliac, Pigmentation | | 1 3.0| Renal, Hyperplasia, Lymphoid | | 1 3.0| Renal, Pigmentation | | 1 3.0| |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + M + + + + + + + + + + + + + + + +| 48 | Hemorrhage | 1 | 3 1.7| Hyperplasia, Lymphoid | 2 3 2 3 2 | 13 2.4| Pigmentation | 2 2 2 3 2 3 2 2 3 2 | 19 2.2| |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia, Lymphoid | 2 2 2 2 2 2 | 10 2.1| |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hematopoietic Cell Proliferation | 3 1 3 2 1 | 11 1.9| Hyperplasia, Lymphoid | 4 3 3 3 | 11 3.3| Lymphoid Follicle, Atrophy | 2 | 1 2.0| Lymphoid Follicle, Hyperplasia | 3 2 2 2 3 3 | 13 2.4| Red Pulp, Congestion | 3 | 1 3.0| |__________________________________________________________________________|____________| Thymus | + + M + + + + + + + + + + + + + + + + + + + + M +| 48 | Atrophy | 3 3 3 3 | 5 2.8| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Galactocele | | 1 | Hyperplasia | 1 1 1 1 2 2 1 1 2 1 1 1 1 1| 24 1.2| |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Edema | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 43 NTP Experiment-Test: 92013-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 01/12/04 Route: DOSED FEED Time: 14:42:16 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 7| 5| 7| 7| | DAY ON TEST | 6| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 1| 3| 8| 3| 2| 2| 2| 0| 2| 3| 3| 6| 3| 3| | | 5| 5| 5| 5| 7| 4| 4| 4| 4| 4| 6| 1| 6| 5| 6| 9| 9| 9| 9| 9| 3| 5| 9| 5| 5| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A | 1250 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| MUSCULOSKELETAL SYSTEM - cont | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperostosis | | 6 2.2| |__________________________________________________________________________|____________| Skeletal Muscle | | 2 | Mineralization | | 1 2.0| _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Compression | | 1 4.0| Hemorrhage | 1 | 2 1.5| |__________________________________________________________________________|____________| Peripheral Nerve | | 2 | Atrophy | | 1 3.0| |__________________________________________________________________________|____________| Spinal Cord | | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemorrhage | 3 1 1 | 4 1.8| Hyperplasia, Lymphoid | 1 1 | 8 1.8| Infiltration Cellular, Histiocyte | 2 2 | 8 2.0| Alveolar Epithelium, Hyperplasia | 1 1 3 1 | 11 1.9| |__________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cataract | | 1 2.0| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 44 NTP Experiment-Test: 92013-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 01/12/04 Route: DOSED FEED Time: 14:42:16 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 7| 5| 7| 7| | DAY ON TEST | 6| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 1| 3| 8| 3| 2| 2| 2| 0| 2| 3| 3| 6| 3| 3| | | 5| 5| 5| 5| 7| 4| 4| 4| 4| 4| 6| 1| 6| 5| 6| 9| 9| 9| 9| 9| 3| 5| 9| 5| 5| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A | 1250 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| SPECIAL SENSES SYSTEM - cont | | | Inflammation, Chronic | | 1 1.0| |__________________________________________________________________________|____________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia, Lymphoid | 2 2 | 3 2.0| Metaplasia, Osseous | 2 | 1 2.0| Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 | 25 1.0| Renal Tubule, Accumulation, Hyaline | | | Droplet | 3 4 | 2 3.5| |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Edema | | 1 4.0| Hyperplasia, Lymphoid | | 3 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 45 NTP Experiment-Test: 92013-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 01/12/04 Route: DOSED FEED Time: 14:42:16 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 1| 3| 2| 3| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 2| 3| 2| 2| 3| 3| 3| | 5| 3| 9| 0| 9| 9| 9| 0| 3| 0| 3| 0| 3| 0| 0| 0| 9| 3| 9| 0| 9| 9| 0| 0| 3| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Gallbladder | A + + + + + + + + + + + + + + + + + + + + + A + M| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| Edema | | Ulcer | | |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | A + + + + + + + + + + + + + + + + + + + + + A + +| Hyperplasia, Lymphoid | 3 | |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Basophilic Focus | X | Clear Cell Focus | X X | Eosinophilic Focus | X X X | Mixed Cell Focus | X X X| Necrosis, Focal | | Tension Lipidosis | X | Hepatocyte, Vacuolization Cytoplasmic| 3 3 | |__________________________________________________________________________| Mesentery | + + + | Hemorrhage | 4 | Fat, Necrosis | 2 2 | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 46 NTP Experiment-Test: 92013-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 01/12/04 Route: DOSED FEED Time: 14:42:16 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 1| 3| 2| 3| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 2| 3| 2| 2| 3| 3| 3| | 5| 3| 9| 0| 9| 9| 9| 0| 3| 0| 3| 0| 3| 0| 0| 0| 9| 3| 9| 0| 9| 9| 0| 0| 3| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | Epithelium, Hyperplasia | 2 1 2 | |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Erosion | | |__________________________________________________________________________| Tongue | + + | |__________________________________________________________________________| Tooth | + + +| Inflammation, Chronic | 2 2 3| Malformation | X | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic | 2 3 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Accessory Adrenal Cortical Nodule | X | Hyperplasia, Focal | 1 2 2 | Hypertrophy, Focal | 1 2 2 1 1 2 2 1 1 | Capsule, Hyperplasia | | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 2 | |__________________________________________________________________________| Parathyroid Gland | M + + + + + + + + + + + + + + + + + + + + + M + +| Cyst | | |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Cyst | 3 | |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Follicle, Cyst | 2 2 1 1 2 2 | __________________________________________|__________________________________________________________________________| Page 47 NTP Experiment-Test: 92013-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 01/12/04 Route: DOSED FEED Time: 14:42:16 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 1| 3| 2| 3| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 2| 3| 2| 2| 3| 3| 3| | 5| 3| 9| 0| 9| 9| 9| 0| 3| 0| 3| 0| 3| 0| 0| 0| 9| 3| 9| 0| 9| 9| 0| 0| 3| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| GENERAL BODY SYSTEM | | |__________________________________________________________________________| Tissue NOS | + | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Atypia Cellular | | Spermatocele | 2 | |__________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 | Inflammation, Chronic | 2 2 2 3 2 1 2 3 2 2 | |__________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| Degeneration | | |__________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 3 2 2 2 2 2| |__________________________________________________________________________| Lymph Node | | Inguinal, Pigmentation | | |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Lymphoid | 2 2 | Pigmentation | 2 2 2 2 2 | |__________________________________________________________________________| Lymph Node, Mesenteric | M + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | | Hyperplasia, Lymphoid | 3 2 | |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | | __________________________________________|__________________________________________________________________________| Page 48 NTP Experiment-Test: 92013-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 01/12/04 Route: DOSED FEED Time: 14:42:16 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 1| 3| 2| 3| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 2| 3| 2| 2| 3| 3| 3| | 5| 3| 9| 0| 9| 9| 9| 0| 3| 0| 3| 0| 3| 0| 0| 0| 9| 3| 9| 0| 9| 9| 0| 0| 3| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | Hematopoietic Cell Proliferation | 3 2 3 3| Hyperplasia, Lymphoid | | Lymphoid Follicle, Hyperplasia | 2 3 2 2 | |__________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + M + + + + + + +| Atrophy | 3 2 2| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Epidermis, Hyperplasia | 1 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Skeletal Muscle | + | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | | Inflammation, Chronic | 3 | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 2 | Hyperplasia, Lymphoid | 1 2 | Infiltration Cellular, Histiocyte | 2| Thrombosis | | Alveolar Epithelium, Hyperplasia | 2 1 2 | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic | | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 49 NTP Experiment-Test: 92013-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 01/12/04 Route: DOSED FEED Time: 14:42:16 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 1| 3| 2| 3| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 2| 3| 2| 2| 3| 3| 3| | 5| 3| 9| 0| 9| 9| 9| 0| 3| 0| 3| 0| 3| 0| 0| 0| 9| 3| 9| 0| 9| 9| 0| 0| 3| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| RESPIRATORY SYSTEM - cont | | Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| Cataract | 3 | Inflammation, Chronic | 1 | |__________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal | 3 | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 3 3 3 3 3 3 3 | Hyperplasia, Lymphoid | 2 2 | Metaplasia, Osseous | 2 | Nephropathy | 3 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 2| |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Edema | | __________________________________________|__________________________________________________________________________ Page 50 NTP Experiment-Test: 92013-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 01/12/04 Route: DOSED FEED Time: 14:42:16 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 4| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| | DAY ON TEST | 3| 3| 3| 2| 3| 3| 3| 5| 3| 8| 2| 3| 3| 1| 3| 3| 2| 2| 3| 3| 3| 3| 2| 3| 9| | | 0| 3| 3| 9| 3| 3| 0| 9| 3| 5| 9| 3| 0| 3| 0| 0| 9| 9| 0| 3| 0| 3| 9| 3| 5| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | 0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Gallbladder | + + + + + + + + + A + + + M + + + + + + + + + + M| 44 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Edema | 2 2 2 | 3 2.0| Ulcer | 4| 1 4.0| |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Hyperplasia, Lymphoid | 3 | 2 3.0| |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Basophilic Focus | | 1 | Clear Cell Focus | X | 3 | Eosinophilic Focus | X X | 5 | Mixed Cell Focus | | 3 | Necrosis, Focal | 2 2| 2 2.0| Tension Lipidosis | | 1 | Hepatocyte, Vacuolization Cytoplasmic| 3 3 | 4 3.0| |__________________________________________________________________________|____________| Mesentery | + | 4 | Hemorrhage | | 1 4.0| Fat, Necrosis | 4 | 3 2.7| |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 51 NTP Experiment-Test: 92013-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 01/12/04 Route: DOSED FEED Time: 14:42:16 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 4| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| | DAY ON TEST | 3| 3| 3| 2| 3| 3| 3| 5| 3| 8| 2| 3| 3| 1| 3| 3| 2| 2| 3| 3| 3| 3| 2| 3| 9| | | 0| 3| 3| 9| 3| 3| 0| 9| 3| 5| 9| 3| 0| 3| 0| 0| 9| 9| 0| 3| 0| 3| 9| 3| 5| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | 0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + M + + + + + + + + + + + + + + + + + +| 49 | Epithelium, Hyperplasia | | 3 1.7| |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + M + + + + + + + + + + + + + + + + + +| 49 | Erosion | 2 2 | 2 2.0| |__________________________________________________________________________|____________| Tongue | + + | 4 | |__________________________________________________________________________|____________| Tooth | + | 4 | Inflammation, Chronic | | 3 2.3| Malformation | | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic | | 2 2.5| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Accessory Adrenal Cortical Nodule | X | 2 | Hyperplasia, Focal | | 3 1.7| Hypertrophy, Focal | 2 1 2 2 1 2 1 2 | 17 1.5| Capsule, Hyperplasia | 2 | 1 2.0| |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 | Hyperplasia | 2 2 | 4 2.0| |__________________________________________________________________________|____________| Parathyroid Gland | + + + + M + + + + + + + + + + + + + + + + + + + +| 47 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 52 NTP Experiment-Test: 92013-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 01/12/04 Route: DOSED FEED Time: 14:42:16 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 4| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| | DAY ON TEST | 3| 3| 3| 2| 3| 3| 3| 5| 3| 8| 2| 3| 3| 1| 3| 3| 2| 2| 3| 3| 3| 3| 2| 3| 9| | | 0| 3| 3| 9| 3| 3| 0| 9| 3| 5| 9| 3| 0| 3| 0| 0| 9| 9| 0| 3| 0| 3| 9| 3| 5| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | 0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | Cyst | 3 | 1 3.0| |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + M| 49 | Pars Distalis, Cyst | | 1 3.0| |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Follicle, Cyst | 2 2 2 3 2 2 1 | 13 1.8| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | |__________________________________________________________________________|____________| Tissue NOS | | 1 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atypia Cellular | 2 | 1 2.0| Spermatocele | | 1 2.0| |__________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | 3 3 3 3 3 3 3 3 3 3 3 | 29 3.0| Inflammation, Chronic | 2 2 1 2 2 4 2 | 17 2.1| |__________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Degeneration | 3 | 1 3.0| |__________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 2 2 2 3 2 2 2 | 13 2.2| |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 53 NTP Experiment-Test: 92013-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 01/12/04 Route: DOSED FEED Time: 14:42:16 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 4| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| | DAY ON TEST | 3| 3| 3| 2| 3| 3| 3| 5| 3| 8| 2| 3| 3| 1| 3| 3| 2| 2| 3| 3| 3| 3| 2| 3| 9| | | 0| 3| 3| 9| 3| 3| 0| 9| 3| 5| 9| 3| 0| 3| 0| 0| 9| 9| 0| 3| 0| 3| 9| 3| 5| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | 0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | Lymph Node | + + | 2 | Inguinal, Pigmentation | 3 | 1 3.0| |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + M + M + + + + +| 48 | Hyperplasia, Lymphoid | 3 3 2 2 2 2 2 2 | 10 2.2| Pigmentation | 2 2 2 2 3| 10 2.1| |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hemorrhage | 1 1 2 2| 4 1.5| Hyperplasia, Lymphoid | 3 2 2 3 3 | 7 2.6| |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + M + + + + + + + + + + + + +| 49 | Angiectasis | 3 | 1 3.0| Hematopoietic Cell Proliferation | 2 1 3 3 1 3| 10 2.4| Hyperplasia, Lymphoid | 4 | 1 4.0| Lymphoid Follicle, Hyperplasia | 3 3 2 2 3 2 | 10 2.4| |__________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + M + + + + + + + + + + +| 48 | Atrophy | 2 2 3 3| 7 2.4| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Epidermis, Hyperplasia | 1 | 2 1.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Skeletal Muscle | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 54 NTP Experiment-Test: 92013-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 01/12/04 Route: DOSED FEED Time: 14:42:16 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 4| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| | DAY ON TEST | 3| 3| 3| 2| 3| 3| 3| 5| 3| 8| 2| 3| 3| 1| 3| 3| 2| 2| 3| 3| 3| 3| 2| 3| 9| | | 0| 3| 3| 9| 3| 3| 0| 9| 3| 5| 9| 3| 0| 3| 0| 0| 9| 9| 0| 3| 0| 3| 9| 3| 5| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | 0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| NERVOUS SYSTEM - cont | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemorrhage | 2 | 1 2.0| Inflammation, Chronic | | 1 3.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemorrhage | 1 2 | 3 1.7| Hyperplasia, Lymphoid | 2 | 3 1.7| Infiltration Cellular, Histiocyte | 2 3 1 3 | 5 2.2| Thrombosis | 2| 1 2.0| Alveolar Epithelium, Hyperplasia | 2 3 2 2| 7 2.0| |__________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic | 2 | 1 2.0| |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cataract | | 1 3.0| Inflammation, Chronic | | 1 1.0| |__________________________________________________________________________|____________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia, Focal | | 1 3.0| _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | 3 3 3 3 3 3 | 13 3.0| Hyperplasia, Lymphoid | | 2 2.0| Metaplasia, Osseous | 2 | 2 2.0| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 55 NTP Experiment-Test: 92013-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 01/12/04 Route: DOSED FEED Time: 14:42:16 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 4| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| | DAY ON TEST | 3| 3| 3| 2| 3| 3| 3| 5| 3| 8| 2| 3| 3| 1| 3| 3| 2| 2| 3| 3| 3| 3| 2| 3| 9| | | 0| 3| 3| 9| 3| 3| 0| 9| 3| 5| 9| 3| 0| 3| 0| 0| 9| 9| 0| 3| 0| 3| 9| 3| 5| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | 0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| URINARY SYSTEM - cont | | | Nephropathy | 1 1 3 1 1 1 1 1 3 2 3 1 2 1 1 | 34 1.4| |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Edema | 3| 1 3.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 56 NTP Experiment-Test: 92013-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 01/12/04 Route: DOSED FEED Time: 14:42:16 _____________________________________________________________________________________________________________________ | 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| DAY ON TEST | 3| 2| 2| 3| 3| 2| 3| 3| 3| 3| 2| 3| 3| 3| 2| 2| 2| 3| 3| 1| 8| 3| 3| 2| 3| | 5| 9| 9| 3| 0| 9| 0| 3| 3| 3| 9| 0| 0| 0| 9| 9| 9| 0| 3| 6| 6| 3| 3| 9| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 312 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Gallbladder | + + + + + + + + + + + + + + + + + + + A A + + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + I + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + A + + + +| Edema | | |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + A + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | A + + + + + + + + + + + + + + + + + + + A + + + +| Hyperplasia, Lymphoid | 3 | |__________________________________________________________________________| Intestine Small, Ileum | A + + + + + + + + + + + + + + + + M + + A + + M +| Hyperplasia, Lymphoid | 3 | |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Clear Cell Focus | X | Cyst | 3 | Eosinophilic Focus | X | Mixed Cell Focus | X X X | Necrosis, Focal | 1 1 | Hepatocyte, Hypertrophy | | Hepatocyte, Vacuolization Cytoplasmic| 3 4 3 | |__________________________________________________________________________| Mesentery | + + | Fat, Necrosis | 3 1 | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + A + + + +| |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Diverticulum | X X | __________________________________________|__________________________________________________________________________| Page 57 NTP Experiment-Test: 92013-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 01/12/04 Route: DOSED FEED Time: 14:42:16 _____________________________________________________________________________________________________________________ | 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| DAY ON TEST | 3| 2| 2| 3| 3| 2| 3| 3| 3| 3| 2| 3| 3| 3| 2| 2| 2| 3| 3| 1| 8| 3| 3| 2| 3| | 5| 9| 9| 3| 0| 9| 0| 3| 3| 3| 9| 0| 0| 0| 9| 9| 9| 0| 3| 6| 6| 3| 3| 9| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 312 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | Ulcer | | Epithelium, Hyperplasia | | |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Tongue | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Accessory Adrenal Cortical Nodule | X X | Hyperplasia, Focal | | Hypertrophy, Focal | 2 2 2 1 3 3 | Capsule, Hyperplasia | 2 | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + A + + + +| Hyperplasia | 2 | |__________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + M + + + +| Pars Distalis, Cyst | 3 | |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Follicle, Cyst | 2 2 1 2 2 1 | Follicular Cell, Hyperplasia | 3 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 58 NTP Experiment-Test: 92013-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 01/12/04 Route: DOSED FEED Time: 14:42:16 _____________________________________________________________________________________________________________________ | 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| DAY ON TEST | 3| 2| 2| 3| 3| 2| 3| 3| 3| 3| 2| 3| 3| 3| 2| 2| 2| 3| 3| 1| 8| 3| 3| 2| 3| | 5| 9| 9| 3| 0| 9| 0| 3| 3| 3| 9| 0| 0| 0| 9| 9| 9| 0| 3| 6| 6| 3| 3| 9| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 312 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| GENITAL SYSTEM - cont | | Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Atypia Cellular | | |__________________________________________________________________________| Penis | + | |__________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 3 3 3 2 3 3 3 3 3 3 3 3 3| Inflammation, Chronic | 3 2 1 3 2 2 2 | |__________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Germinal Epithelium, Atrophy | 3 2 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 2 2 2 3 2 2| |__________________________________________________________________________| Lymph Node | + + | |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 2 | Hyperplasia, Lymphoid | 2 2 3 | Pigmentation | 2 2 2 | |__________________________________________________________________________| Lymph Node, Mesenteric | M + + + + + + + + + + + + + + + + + + + A + + + +| Hemorrhage | 2 2 3 2| Hyperplasia, Lymphoid | 4 | |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + A + + + +| Angiectasis | | Hematopoietic Cell Proliferation | 1 4 4 1 | Hyperplasia, Lymphoid | | Lymphoid Follicle, Atrophy | 3 | Lymphoid Follicle, Hyperplasia | 2 2 3 2 | __________________________________________|__________________________________________________________________________| Page 59 NTP Experiment-Test: 92013-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 01/12/04 Route: DOSED FEED Time: 14:42:16 _____________________________________________________________________________________________________________________ | 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| DAY ON TEST | 3| 2| 2| 3| 3| 2| 3| 3| 3| 3| 2| 3| 3| 3| 2| 2| 2| 3| 3| 1| 8| 3| 3| 2| 3| | 5| 9| 9| 3| 0| 9| 0| 3| 3| 3| 9| 0| 0| 0| 9| 9| 9| 0| 3| 6| 6| 3| 3| 9| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 312 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | |__________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + M + + + +| Atrophy | 3 3 3 | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Edema | 3 2 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrous Osteodystrophy | 2 | |__________________________________________________________________________| Skeletal Muscle | | Necrosis | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 2 | Hyperplasia, Lymphoid | 2 | Infiltration Cellular, Histiocyte | 1 2 | Alveolar Epithelium, Hyperplasia | 1 1 | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 60 NTP Experiment-Test: 92013-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 01/12/04 Route: DOSED FEED Time: 14:42:16 _____________________________________________________________________________________________________________________ | 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| DAY ON TEST | 3| 2| 2| 3| 3| 2| 3| 3| 3| 3| 2| 3| 3| 3| 2| 2| 2| 3| 3| 1| 8| 3| 3| 2| 3| | 5| 9| 9| 3| 0| 9| 0| 3| 3| 3| 9| 0| 0| 0| 9| 9| 9| 0| 3| 6| 6| 3| 3| 9| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 312 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| SPECIAL SENSES SYSTEM - cont | | |__________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal | 2 | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 3 3 3 3 3 | Hyperplasia, Lymphoid | 3 | Inflammation, Chronic Active | 3 | Metaplasia, Osseous | 1 | Nephropathy | 4 2 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1| |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Edema | | __________________________________________|__________________________________________________________________________ Page 61 NTP Experiment-Test: 92013-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 01/12/04 Route: DOSED FEED Time: 14:42:16 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| | DAY ON TEST | 2| 3| 2| 3| 3| 3| 1| 3| 2| 3| 2| 3| 3| 2| 2| 3| 3| 3| 3| 3| 3| 1| 2| 7| 2| | | 9| 0| 9| 0| 0| 3| 3| 3| 9| 3| 9| 3| 0| 9| 9| 0| 3| 0| 0| 0| 0| 5| 9| 6| 9| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A | 312 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Gallbladder | + + + + + + + + + + + + + + + + + + M + + M + + +| 46 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Edema | 2 | 1 2.0| |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + A +| 47 | Hyperplasia, Lymphoid | 2 | 2 2.5| |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 | Hyperplasia, Lymphoid | | 1 3.0| |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Clear Cell Focus | X X | 3 | Cyst | | 1 3.0| Eosinophilic Focus | 2 | 2 2.0| Mixed Cell Focus | X X X X | 7 | Necrosis, Focal | 1 | 3 1.0| Hepatocyte, Hypertrophy | 3 | 1 3.0| Hepatocyte, Vacuolization Cytoplasmic| 3 4 | 5 3.4| |__________________________________________________________________________|____________| Mesentery | + + + + +| 7 | Fat, Necrosis | 2| 3 2.0| |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 62 NTP Experiment-Test: 92013-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 01/12/04 Route: DOSED FEED Time: 14:42:16 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| | DAY ON TEST | 2| 3| 2| 3| 3| 3| 1| 3| 2| 3| 2| 3| 3| 2| 2| 3| 3| 3| 3| 3| 3| 1| 2| 7| 2| | | 9| 0| 9| 0| 0| 3| 3| 3| 9| 3| 9| 3| 0| 9| 9| 0| 3| 0| 0| 0| 0| 5| 9| 6| 9| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A | 312 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Diverticulum | | 2 | Ulcer | 3 | 1 3.0| Epithelium, Hyperplasia | 4 3 | 2 3.5| |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Tongue | + | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Accessory Adrenal Cortical Nodule | X X | 4 | Hyperplasia, Focal | 3 1 | 2 2.0| Hypertrophy, Focal | 2 1 2 1 2 | 11 1.9| Capsule, Hyperplasia | | 1 2.0| |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hyperplasia | 2 | 2 2.0| |__________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + M +| 49 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + M + + + + + + +| 48 | Pars Distalis, Cyst | 3 3 | 3 3.0| |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 63 NTP Experiment-Test: 92013-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 01/12/04 Route: DOSED FEED Time: 14:42:16 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| | DAY ON TEST | 2| 3| 2| 3| 3| 3| 1| 3| 2| 3| 2| 3| 3| 2| 2| 3| 3| 3| 3| 3| 3| 1| 2| 7| 2| | | 9| 0| 9| 0| 0| 3| 3| 3| 9| 3| 9| 3| 0| 9| 9| 0| 3| 0| 0| 0| 0| 5| 9| 6| 9| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A | 312 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | Follicle, Cyst | 2 1 2 1 2 1 3 | 13 1.7| Follicular Cell, Hyperplasia | | 1 3.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atypia Cellular | 3 | 1 3.0| |__________________________________________________________________________|____________| Penis | | 1 | |__________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | 3 3 3 3 3 3 3 3 3 3 3 3 3 3| 27 3.0| Inflammation, Chronic | 2 2 2 1 2 2 2 2 4 2 3 1 | 19 2.1| |__________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Germinal Epithelium, Atrophy | 2 | 3 2.3| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 2 2 2 2 2 2 2 2 | 15 2.1| |__________________________________________________________________________|____________| Lymph Node | | 2 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hematopoietic Cell Proliferation | 2 | 2 2.0| Hyperplasia, Lymphoid | 2 3 2 2 2 | 8 2.3| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 64 NTP Experiment-Test: 92013-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 01/12/04 Route: DOSED FEED Time: 14:42:16 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| | DAY ON TEST | 2| 3| 2| 3| 3| 3| 1| 3| 2| 3| 2| 3| 3| 2| 2| 3| 3| 3| 3| 3| 3| 1| 2| 7| 2| | | 9| 0| 9| 0| 0| 3| 3| 3| 9| 3| 9| 3| 0| 9| 9| 0| 3| 0| 0| 0| 0| 5| 9| 6| 9| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A | 312 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | Pigmentation | 3 2 | 5 2.2| |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Hemorrhage | 2 1 2 | 7 2.0| Hyperplasia, Lymphoid | 3 2 2 | 4 2.8| |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Angiectasis | 3 | 1 3.0| Hematopoietic Cell Proliferation | 1 2 3 2 4 3 4 2 4 3 | 14 2.7| Hyperplasia, Lymphoid | 3 | 1 3.0| Lymphoid Follicle, Atrophy | | 1 3.0| Lymphoid Follicle, Hyperplasia | 2 2 2 2 | 8 2.1| |__________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Atrophy | 3 2 2 2 | 7 2.6| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Edema | | 2 2.5| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrous Osteodystrophy | | 1 2.0| |__________________________________________________________________________|____________| Skeletal Muscle | + + | 2 | Necrosis | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 65 NTP Experiment-Test: 92013-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 01/12/04 Route: DOSED FEED Time: 14:42:16 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| | DAY ON TEST | 2| 3| 2| 3| 3| 3| 1| 3| 2| 3| 2| 3| 3| 2| 2| 3| 3| 3| 3| 3| 3| 1| 2| 7| 2| | | 9| 0| 9| 0| 0| 3| 3| 3| 9| 3| 9| 3| 0| 9| 9| 0| 3| 0| 0| 0| 0| 5| 9| 6| 9| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A | 312 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemorrhage | 2 | 2 2.0| Hyperplasia, Lymphoid | 2 | 2 2.0| Infiltration Cellular, Histiocyte | 2 2 2 1| 6 1.7| Alveolar Epithelium, Hyperplasia | 1 | 3 1.0| |__________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia, Focal | | 1 2.0| _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | 3 3 3 3 3 3 3| 12 3.0| Hyperplasia, Lymphoid | 3 | 2 3.0| Inflammation, Chronic Active | | 1 3.0| Metaplasia, Osseous | 2 2 | 3 1.7| Nephropathy | 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 2 2| 40 1.2| |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + M + + + + + +| 49 | Edema | 3 | 1 3.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 66 NTP Experiment-Test: 92013-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 01/12/04 Route: DOSED FEED Time: 14:42:16 _____________________________________________________________________________________________________________________ | 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| DAY ON TEST | 3| 3| 3| 3| 3| 3| 2| 3| 2| 2| 2| 2| 3| 2| 2| 2| 3| 2| 2| 3| 3| 3| 3| 3| 3| | 0| 0| 0| 2| 0| 3| 9| 3| 9| 9| 9| 9| 0| 9| 9| 9| 0| 9| 9| 0| 0| 3| 5| 0| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 625 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | M + + + + + + + M + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| Edema | 2 2 | Hyperplasia, Lymphoid | | Inflammation | | Ulcer | | |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | | Hyperplasia, Lymphoid | 2 2 | |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Basophilic Focus | | Clear Cell Focus | | Eosinophilic Focus | | Infiltration Cellular, Mixed Cell | 2 | Mixed Cell Focus | X | Necrosis, Focal | 3 | Tension Lipidosis | | Centrilobular, Necrosis | 1 | Hepatocyte, Vacuolization Cytoplasmic| | |__________________________________________________________________________| Mesentery | | Fat, Necrosis | | |__________________________________________________________________________| Oral Mucosa | | __________________________________________|__________________________________________________________________________| Page 67 NTP Experiment-Test: 92013-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 01/12/04 Route: DOSED FEED Time: 14:42:16 _____________________________________________________________________________________________________________________ | 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| DAY ON TEST | 3| 3| 3| 3| 3| 3| 2| 3| 2| 2| 2| 2| 3| 2| 2| 2| 3| 2| 2| 3| 3| 3| 3| 3| 3| | 0| 0| 0| 2| 0| 3| 9| 3| 9| 9| 9| 9| 0| 9| 9| 9| 0| 9| 9| 0| 0| 3| 5| 0| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 625 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 3 | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Diverticulum | X | Erosion | 1 | Inflammation, Chronic | 3 2 | Ulcer | | Epithelium, Hyperplasia | 3 3 1 | |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Erosion | 2 | |__________________________________________________________________________| Tongue | + + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic | | Mineralization | 1 | Myocardium, Necrosis | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Accessory Adrenal Cortical Nodule | X | Hyperplasia, Focal | 1 | Hypertrophy, Focal | 1 2 1 2| Capsule, Hyperplasia | 2 2 | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 68 NTP Experiment-Test: 92013-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 01/12/04 Route: DOSED FEED Time: 14:42:16 _____________________________________________________________________________________________________________________ | 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| DAY ON TEST | 3| 3| 3| 3| 3| 3| 2| 3| 2| 2| 2| 2| 3| 2| 2| 2| 3| 2| 2| 3| 3| 3| 3| 3| 3| | 0| 0| 0| 2| 0| 3| 9| 3| 9| 9| 9| 9| 0| 9| 9| 9| 0| 9| 9| 0| 0| 3| 5| 0| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 625 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ENDOCRINE SYSTEM - cont | | Cyst | 3 | |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + M + + + + + + + + +| Pars Distalis, Cyst | 3 | |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Follicle, Cyst | 2 1 2 2 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3| Inflammation, Chronic | 2 2 2 2 2 1 1 2 4 1 2 | |__________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Germinal Epithelium, Atrophy | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 2 2 2 2 | |__________________________________________________________________________| Lymph Node | | |__________________________________________________________________________| Lymph Node, Mandibular | M + + + + + + + + + + + + + + + + + + + + + + M +| Hyperplasia, Lymphoid | 2 2 2 2 | Pigmentation | 2 3 2 2 2 | |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 69 NTP Experiment-Test: 92013-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 01/12/04 Route: DOSED FEED Time: 14:42:16 _____________________________________________________________________________________________________________________ | 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| DAY ON TEST | 3| 3| 3| 3| 3| 3| 2| 3| 2| 2| 2| 2| 3| 2| 2| 2| 3| 2| 2| 3| 3| 3| 3| 3| 3| | 0| 0| 0| 2| 0| 3| 9| 3| 9| 9| 9| 9| 0| 9| 9| 9| 0| 9| 9| 0| 0| 3| 5| 0| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 625 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | Hemorrhage | 1 1 2 2| Hyperplasia, Lymphoid | 2 3 | |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 4 2 2 1 2 | Hyperplasia, Lymphoid | | Lymphoid Follicle, Atrophy | | Lymphoid Follicle, Hyperplasia | 3 2 | |__________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + I +| Atrophy | 3 | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Ulcer | | Epidermis, Hyperplasia | 1| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Skeletal Muscle | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | 2 | Hemorrhage | 2 | Hyperplasia, Lymphoid | 2 2 | Infiltration Cellular, Histiocyte | 1 3 2 | Metaplasia, Osseous | 1 | __________________________________________|__________________________________________________________________________| Page 70 NTP Experiment-Test: 92013-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 01/12/04 Route: DOSED FEED Time: 14:42:16 _____________________________________________________________________________________________________________________ | 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| DAY ON TEST | 3| 3| 3| 3| 3| 3| 2| 3| 2| 2| 2| 2| 3| 2| 2| 2| 3| 2| 2| 3| 3| 3| 3| 3| 3| | 0| 0| 0| 2| 0| 3| 9| 3| 9| 9| 9| 9| 0| 9| 9| 9| 0| 9| 9| 0| 0| 3| 5| 0| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 625 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| RESPIRATORY SYSTEM - cont | | Alveolar Epithelium, Hyperplasia | 2 | Bronchiole, Epithelium, Hyperplasia | 1 | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic | 3 | |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal | 3 | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 3 3 3 3 3 | Hydronephrosis | | Mineralization | 3 | Nephropathy | 1 1 1 2 1 1 2 1 3 1 1 1 1 1 1 3 1 3 1 1| Renal Tubule, Necrosis | 2 | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________ Page 71 NTP Experiment-Test: 92013-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 01/12/04 Route: DOSED FEED Time: 14:42:16 __________________________________________________________________________________________________________________________________ | 7| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 6| 6| 5| 7| 7| 7| 7| | DAY ON TEST | 3| 2| 3| 3| 3| 3| 4| 3| 3| 3| 3| 2| 4| 2| 2| 2| 3| 3| 2| 8| 6| 3| 2| 3| 3| | | 3| 2| 0| 3| 3| 3| 1| 3| 3| 0| 3| 9| 8| 9| 9| 9| 3| 0| 3| 6| 9| 0| 9| 3| 0| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | 625 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Gallbladder | + A + + + + + + + + + + + + + + + + + A + + + + +| 48 | |__________________________________________________________________________|____________| Intestine Large, Colon | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + A + + + + + + + + + + + + + + + + A A + + + + +| 47 | Edema | 2 | 3 2.0| Hyperplasia, Lymphoid | 4 | 1 4.0| Inflammation | 4 | 1 4.0| Ulcer | 4 | 1 4.0| |__________________________________________________________________________|____________| Intestine Small, Duodenum | + A + + + + + + + + + + + + + + + + + A + + + + +| 48 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + A + + + + + + + + + + + + + + + + + A + + + + +| 48 | Hemorrhage | 3 | 1 3.0| Hyperplasia, Lymphoid | 4| 3 2.7| |__________________________________________________________________________|____________| Intestine Small, Ileum | + A + + + M + + + + + + + + + + + + + + + + + + +| 48 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Basophilic Focus | X | 1 | Clear Cell Focus | X X | 2 | Eosinophilic Focus | X | 1 | Infiltration Cellular, Mixed Cell | 1 2 | 3 1.7| Mixed Cell Focus | X | 2 | Necrosis, Focal | 1 | 2 2.0| Tension Lipidosis | X | 1 | Centrilobular, Necrosis | | 1 1.0| Hepatocyte, Vacuolization Cytoplasmic| 4 3| 2 3.5| |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 72 NTP Experiment-Test: 92013-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 01/12/04 Route: DOSED FEED Time: 14:42:16 __________________________________________________________________________________________________________________________________ | 7| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 6| 6| 5| 7| 7| 7| 7| | DAY ON TEST | 3| 2| 3| 3| 3| 3| 4| 3| 3| 3| 3| 2| 4| 2| 2| 2| 3| 3| 2| 8| 6| 3| 2| 3| 3| | | 3| 2| 0| 3| 3| 3| 1| 3| 3| 0| 3| 9| 8| 9| 9| 9| 3| 0| 3| 6| 9| 0| 9| 3| 0| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | 625 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | Mesentery | + + | 2 | Fat, Necrosis | 3 2 | 2 2.5| |__________________________________________________________________________|____________| Oral Mucosa | + | 1 | |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | | 1 3.0| |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Diverticulum | | 1 | Erosion | | 1 1.0| Inflammation, Chronic | | 2 2.5| Ulcer | 3 | 1 3.0| Epithelium, Hyperplasia | 2 | 4 2.3| |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + A + + + + +| 49 | Erosion | | 1 2.0| |__________________________________________________________________________|____________| Tongue | | 2 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic | 2 1 | 2 1.5| Mineralization | 3 | 2 2.0| Myocardium, Necrosis | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Accessory Adrenal Cortical Nodule | X X X X X | 6 | Hyperplasia, Focal | | 1 1.0| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 73 NTP Experiment-Test: 92013-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 01/12/04 Route: DOSED FEED Time: 14:42:16 __________________________________________________________________________________________________________________________________ | 7| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 6| 6| 5| 7| 7| 7| 7| | DAY ON TEST | 3| 2| 3| 3| 3| 3| 4| 3| 3| 3| 3| 2| 4| 2| 2| 2| 3| 3| 2| 8| 6| 3| 2| 3| 3| | | 3| 2| 0| 3| 3| 3| 1| 3| 3| 0| 3| 9| 8| 9| 9| 9| 3| 0| 3| 6| 9| 0| 9| 3| 0| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | 625 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | Hypertrophy, Focal | 1 4 1 1 1 1| 10 1.5| Capsule, Hyperplasia | | 2 2.0| |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + M| 49 | Cyst | | 1 3.0| |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Pars Distalis, Cyst | 3 3 | 3 3.0| |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Follicle, Cyst | 2 2 3 2 2 1 2 1 1 | 13 1.8| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | 3 3 3 3 3 3 3 3 3 3 3 3 3 | 31 3.0| Inflammation, Chronic | 2 1 2 2 2 3 2 4 1 2 2 2 4 | 24 2.1| |__________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Germinal Epithelium, Atrophy | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 74 NTP Experiment-Test: 92013-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 01/12/04 Route: DOSED FEED Time: 14:42:16 __________________________________________________________________________________________________________________________________ | 7| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 6| 6| 5| 7| 7| 7| 7| | DAY ON TEST | 3| 2| 3| 3| 3| 3| 4| 3| 3| 3| 3| 2| 4| 2| 2| 2| 3| 3| 2| 8| 6| 3| 2| 3| 3| | | 3| 2| 0| 3| 3| 3| 1| 3| 3| 0| 3| 9| 8| 9| 9| 9| 3| 0| 3| 6| 9| 0| 9| 3| 0| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | 625 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 3 3 2 2 3 4 2 2 3 | 14 2.4| |__________________________________________________________________________|____________| Lymph Node | + | 1 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Hyperplasia, Lymphoid | 3 2 2 2 2 | 9 2.1| Pigmentation | 2 2 | 7 2.1| |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + M + + + + + + + + + + + + + + + + + A + + + + +| 48 | Hemorrhage | | 4 1.5| Hyperplasia, Lymphoid | 3 3 | 4 2.8| |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hematopoietic Cell Proliferation | 4 2 4 3 | 9 2.7| Hyperplasia, Lymphoid | 3 3| 2 3.0| Lymphoid Follicle, Atrophy | 4 | 1 4.0| Lymphoid Follicle, Hyperplasia | | 2 2.5| |__________________________________________________________________________|____________| Thymus | + M + M + + + + + + + + + + + + + + M M + + + + +| 45 | Atrophy | 2 3 3 2 | 5 2.6| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Ulcer | 4 | 1 4.0| Epidermis, Hyperplasia | 3 | 2 2.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 75 NTP Experiment-Test: 92013-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 01/12/04 Route: DOSED FEED Time: 14:42:16 __________________________________________________________________________________________________________________________________ | 7| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 6| 6| 5| 7| 7| 7| 7| | DAY ON TEST | 3| 2| 3| 3| 3| 3| 4| 3| 3| 3| 3| 2| 4| 2| 2| 2| 3| 3| 2| 8| 6| 3| 2| 3| 3| | | 3| 2| 0| 3| 3| 3| 1| 3| 3| 0| 3| 9| 8| 9| 9| 9| 3| 0| 3| 6| 9| 0| 9| 3| 0| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | 625 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| MUSCULOSKELETAL SYSTEM - cont | | | |__________________________________________________________________________|____________| Skeletal Muscle | + | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Congestion | | 1 2.0| Hemorrhage | | 1 2.0| Hyperplasia, Lymphoid | 2 2 2 1 | 6 1.8| Infiltration Cellular, Histiocyte | 2 1 | 5 1.8| Metaplasia, Osseous | | 1 1.0| Alveolar Epithelium, Hyperplasia | | 1 2.0| Bronchiole, Epithelium, Hyperplasia | | 1 1.0| |__________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic | 2 | 2 2.5| |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia, Focal | | 1 3.0| _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | 3 3 3 3 3 3 3 | 12 3.0| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 76 NTP Experiment-Test: 92013-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 01/12/04 Route: DOSED FEED Time: 14:42:16 __________________________________________________________________________________________________________________________________ | 7| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 6| 6| 5| 7| 7| 7| 7| | DAY ON TEST | 3| 2| 3| 3| 3| 3| 4| 3| 3| 3| 3| 2| 4| 2| 2| 2| 3| 3| 2| 8| 6| 3| 2| 3| 3| | | 3| 2| 0| 3| 3| 3| 1| 3| 3| 0| 3| 9| 8| 9| 9| 9| 3| 0| 3| 6| 9| 0| 9| 3| 0| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | 625 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| URINARY SYSTEM - cont | | | Hydronephrosis | 2 | 1 2.0| Mineralization | 3 | 2 3.0| Nephropathy | 1 2 1 2 1 2 1 1 2 1 1 1 1 1 1 1 2 1| 38 1.3| Renal Tubule, Necrosis | | 1 2.0| |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + I + + + + + + + +| 49 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 77 NTP Experiment-Test: 92013-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 01/12/04 Route: DOSED FEED Time: 14:42:16 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 2| 2| 3| 2| 3| 3| 3| 2| 2| 3| 3| 3| | 3| 3| 3| 3| 3| 0| 0| 7| 0| 0| 3| 9| 3| 9| 9| 0| 9| 0| 0| 0| 8| 9| 3| 3| 3| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1250 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + I + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| Edema | 2 2 | |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Lymphoid | | |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Basophilic Focus | | Clear Cell Focus | | Cyst | | Eosinophilic Focus | X | Hyperplasia, Lymphoid | | Infiltration Cellular, Mixed Cell | | Hepatocyte, Hypertrophy | | |__________________________________________________________________________| Mesentery | | Fat, Necrosis | | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Acinus, Hyperplasia, Focal | 2 | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Diverticulum | | __________________________________________|__________________________________________________________________________| Page 78 NTP Experiment-Test: 92013-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 01/12/04 Route: DOSED FEED Time: 14:42:16 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 2| 2| 3| 2| 3| 3| 3| 2| 2| 3| 3| 3| | 3| 3| 3| 3| 3| 0| 0| 7| 0| 0| 3| 9| 3| 9| 9| 0| 9| 0| 0| 0| 8| 9| 3| 3| 3| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1250 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | Hyperplasia | 4 | |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Erosion | 2 | Glands, Hyperplasia | | |__________________________________________________________________________| Tongue | + + | |__________________________________________________________________________| Tooth | + + + | Inflammation, Chronic | 2 3 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + | |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic | | Thrombosis | 4 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Accessory Adrenal Cortical Nodule | X | Hyperplasia, Focal | | Hypertrophy, Focal | 2 2 1 1 2 4 | Capsule, Hyperplasia | 2 2 | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 | |__________________________________________________________________________| Parathyroid Gland | + + + + + + + M + + + + + + + + + + + + + + + + +| Cyst | 3 | |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Cyst | 3 | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 79 NTP Experiment-Test: 92013-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 01/12/04 Route: DOSED FEED Time: 14:42:16 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 2| 2| 3| 2| 3| 3| 3| 2| 2| 3| 3| 3| | 3| 3| 3| 3| 3| 0| 0| 7| 0| 0| 3| 9| 3| 9| 9| 0| 9| 0| 0| 0| 8| 9| 3| 3| 3| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1250 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ENDOCRINE SYSTEM - cont | | Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Follicle, Cyst | 2 2 1 2 2 2 1 3 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Spermatocele | | |__________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3| Inflammation, Chronic | 4 2 2 2 3 2 2 3 2 1| |__________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Germinal Epithelium, Atrophy | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 3 3 2 3 2 3 2 2| |__________________________________________________________________________| Lymph Node | + + | Inguinal, Hyperplasia, Lymphoid | 2 | Pancreatic, Hyperplasia, Lymphoid | 2 | |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + M + + + + + M + + + + + M + M + + + +| Hematopoietic Cell Proliferation | | Hyperplasia, Lymphoid | 2 2 2 2 3| Pigmentation | 2 2 2 | |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | | __________________________________________|__________________________________________________________________________| Page 80 NTP Experiment-Test: 92013-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 01/12/04 Route: DOSED FEED Time: 14:42:16 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 2| 2| 3| 2| 3| 3| 3| 2| 2| 3| 3| 3| | 3| 3| 3| 3| 3| 0| 0| 7| 0| 0| 3| 9| 3| 9| 9| 0| 9| 0| 0| 0| 8| 9| 3| 3| 3| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1250 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | Hemorrhage | 2 1 2 3 2 | Hyperplasia, Lymphoid | 4 2 2 3 2 3 | |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | | Hematopoietic Cell Proliferation | 2 3 2 4 2 2 1 3 | Hyperplasia, Lymphoid | | Lymphoid Follicle, Atrophy | 3 | Lymphoid Follicle, Hyperplasia | 2 2 2 | |__________________________________________________________________________| Thymus | + + + + M + + + + + + + M + + + + + + + + + M + +| Atrophy | 3 3 2 3 3 | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst Epithelial Inclusion | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrous Osteodystrophy | 2 | |__________________________________________________________________________| Skeletal Muscle | | Atrophy | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Peripheral Nerve | + | Atrophy | | |__________________________________________________________________________| Spinal Cord | + | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | __________________________________________|__________________________________________________________________________| Page 81 NTP Experiment-Test: 92013-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 01/12/04 Route: DOSED FEED Time: 14:42:16 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 2| 2| 3| 2| 3| 3| 3| 2| 2| 3| 3| 3| | 3| 3| 3| 3| 3| 0| 0| 7| 0| 0| 3| 9| 3| 9| 9| 0| 9| 0| 0| 0| 8| 9| 3| 3| 3| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1250 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| RESPIRATORY SYSTEM - cont | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | | Hemorrhage | 2 1 1 | Hyperplasia, Lymphoid | 2 | Infiltration Cellular, Histiocyte | 1 4 3 2 1 | Alveolar Epithelium, Hyperplasia | 2 3 1 2 2 2| Bronchiole, Epithelium, Hyperplasia | | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| Cataract | 2 | Inflammation, Chronic | 2 | |__________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal | 2 | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 3 | Hydronephrosis | | Hyperplasia, Lymphoid | 2 2 | Metaplasia, Osseous | | Nephropathy | 1 1 2 2 3 1 1 1 1 1 2 1 1 2 4 2 1 1| |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________ Page 82 NTP Experiment-Test: 92013-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 01/12/04 Route: DOSED FEED Time: 14:42:16 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 4| 3| 3| 3| 3| 2| 3| 2| 3| 3| 5| 3| 3| 2| 3| 2| 3| 3| 3| 3| 3| 3| 3| | | 0| 3| 5| 0| 3| 3| 0| 9| 0| 9| 0| 0| 5| 0| 0| 9| 3| 9| 0| 3| 3| 3| 0| 3| 3| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A | 1250 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Gallbladder | + + + + + + + + + + + + M + + + + + + + + + + + M| 48 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Edema | 2 2 | 4 2.0| |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia, Lymphoid | 3 | 1 3.0| |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + M + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Basophilic Focus | X | 1 | Clear Cell Focus | X X X | 3 | Cyst | 3 | 1 3.0| Eosinophilic Focus | | 1 | Hyperplasia, Lymphoid | 4 | 1 4.0| Infiltration Cellular, Mixed Cell | 2 | 1 2.0| Hepatocyte, Hypertrophy | 3 | 1 3.0| |__________________________________________________________________________|____________| Mesentery | + + + | 3 | Fat, Necrosis | 2 2 | 2 2.0| |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Acinus, Hyperplasia, Focal | | 1 2.0| |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 83 NTP Experiment-Test: 92013-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 01/12/04 Route: DOSED FEED Time: 14:42:16 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 4| 3| 3| 3| 3| 2| 3| 2| 3| 3| 5| 3| 3| 2| 3| 2| 3| 3| 3| 3| 3| 3| 3| | | 0| 3| 5| 0| 3| 3| 0| 9| 0| 9| 0| 0| 5| 0| 0| 9| 3| 9| 0| 3| 3| 3| 0| 3| 3| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A | 1250 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Diverticulum | X | 1 | Hyperplasia | | 1 4.0| |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Erosion | | 1 2.0| Glands, Hyperplasia | 3 | 1 3.0| |__________________________________________________________________________|____________| Tongue | + + | 4 | |__________________________________________________________________________|____________| Tooth | | 3 | Inflammation, Chronic | | 2 2.5| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | | 1 | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic | 2 | 1 2.0| Thrombosis | | 1 4.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Accessory Adrenal Cortical Nodule | X X X X X X X | 8 | Hyperplasia, Focal | 1 | 1 1.0| Hypertrophy, Focal | 1 1 1 3 2 4 1 1 | 14 1.9| Capsule, Hyperplasia | 2 2 2 | 5 2.0| |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 84 NTP Experiment-Test: 92013-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 01/12/04 Route: DOSED FEED Time: 14:42:16 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 4| 3| 3| 3| 3| 2| 3| 2| 3| 3| 5| 3| 3| 2| 3| 2| 3| 3| 3| 3| 3| 3| 3| | | 0| 3| 5| 0| 3| 3| 0| 9| 0| 9| 0| 0| 5| 0| 0| 9| 3| 9| 0| 3| 3| 3| 0| 3| 3| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A | 1250 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | Hyperplasia | | 1 2.0| |__________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Cyst | | 1 3.0| |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Pars Distalis, Cyst | 3 | 2 3.0| |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Follicle, Cyst | 2 3 2 3 2 1 | 14 2.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Spermatocele | 3 | 1 3.0| |__________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | 3 3 3 3 3 3 2 3 3 2 3 3 3 3 3 3| 36 2.9| Inflammation, Chronic | 2 2 1 2 2 3 4 1 1 2 1 1 3| 23 2.1| |__________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Germinal Epithelium, Atrophy | 2 3 3 | 3 2.7| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 2 2 2 2 3 2| 15 2.3| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 85 NTP Experiment-Test: 92013-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 01/12/04 Route: DOSED FEED Time: 14:42:16 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 4| 3| 3| 3| 3| 2| 3| 2| 3| 3| 5| 3| 3| 2| 3| 2| 3| 3| 3| 3| 3| 3| 3| | | 0| 3| 5| 0| 3| 3| 0| 9| 0| 9| 0| 0| 5| 0| 0| 9| 3| 9| 0| 3| 3| 3| 0| 3| 3| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A | 1250 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | |__________________________________________________________________________|____________| Lymph Node | | 2 | Inguinal, Hyperplasia, Lymphoid | | 1 2.0| Pancreatic, Hyperplasia, Lymphoid | | 1 2.0| |__________________________________________________________________________|____________| Lymph Node, Mandibular | + M + + + + + + + + + + + + + + + + + + + + + + +| 45 | Hematopoietic Cell Proliferation | 2| 1 2.0| Hyperplasia, Lymphoid | 2 2 2 2 2 2 2 | 12 2.1| Pigmentation | 2 2 2 2 2 2 2 2 2 | 12 2.0| |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hematopoietic Cell Proliferation | 2 | 1 2.0| Hemorrhage | 1 3 3 1 1 2 2 2 3 | 14 2.0| Hyperplasia, Lymphoid | 2 | 7 2.6| |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | 3 | 1 3.0| Hematopoietic Cell Proliferation | 4 3 4 2| 12 2.7| Hyperplasia, Lymphoid | 4 4 | 2 4.0| Lymphoid Follicle, Atrophy | | 1 3.0| Lymphoid Follicle, Hyperplasia | 2 2 2 2| 7 2.0| |__________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + + + + + + + + + + M + I| 45 | Atrophy | 3 2 3 | 8 2.8| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + I + + + + + + + +| 49 | Cyst Epithelial Inclusion | X | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 86 NTP Experiment-Test: 92013-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 01/12/04 Route: DOSED FEED Time: 14:42:16 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 4| 3| 3| 3| 3| 2| 3| 2| 3| 3| 5| 3| 3| 2| 3| 2| 3| 3| 3| 3| 3| 3| 3| | | 0| 3| 5| 0| 3| 3| 0| 9| 0| 9| 0| 0| 5| 0| 0| 9| 3| 9| 0| 3| 3| 3| 0| 3| 3| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A | 1250 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| MUSCULOSKELETAL SYSTEM - cont | | | Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrous Osteodystrophy | | 1 2.0| |__________________________________________________________________________|____________| Skeletal Muscle | + | 1 | Atrophy | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Peripheral Nerve | + | 2 | Atrophy | 3 | 1 3.0| |__________________________________________________________________________|____________| Spinal Cord | + | 2 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Congestion | 4 | 1 4.0| Hemorrhage | 1 1 | 5 1.2| Hyperplasia, Lymphoid | 2 | 2 2.0| Infiltration Cellular, Histiocyte | 1 1 2 2 1 1 | 11 1.7| Alveolar Epithelium, Hyperplasia | 1 3 1 | 9 1.9| Bronchiole, Epithelium, Hyperplasia | 1 | 1 1.0| |__________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cataract | 1 | 2 1.5| Inflammation, Chronic | | 1 2.0| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 87 NTP Experiment-Test: 92013-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 01/12/04 Route: DOSED FEED Time: 14:42:16 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 4| 3| 3| 3| 3| 2| 3| 2| 3| 3| 5| 3| 3| 2| 3| 2| 3| 3| 3| 3| 3| 3| 3| | | 0| 3| 5| 0| 3| 3| 0| 9| 0| 9| 0| 0| 5| 0| 0| 9| 3| 9| 0| 3| 3| 3| 0| 3| 3| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A | 1250 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| SPECIAL SENSES SYSTEM - cont | | | |__________________________________________________________________________|____________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia, Focal | 2 3 | 3 2.3| _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | 3 3 3 3 3 3 | 7 3.0| Hydronephrosis | 2| 1 2.0| Hyperplasia, Lymphoid | | 2 2.0| Metaplasia, Osseous | 2 2 | 2 2.0| Nephropathy | 1 1 1 2 2 1 1 2 3 1 1 1 1 1 1 4 4| 35 1.6| |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 88 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------
Web page last updated on August 07, 2005
The National Institute of Environmental Health Sciences is one of the National Institutes of Health within the U.S. Department of Health and Human Services. The National Toxicology Program is headquartered on the NIEHS campus in Research Triangle Park, NC.