Pathology Tables for Peer Review
The National Toxicology Program
NTP Experiment-Test: 89002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PENTACHLOROPHENOL Date: 10/28/97 Route: DOSED FEED Time: 08:30:52 27 WEEK SSAC Facility: Battelle Columbus Laboratory Chemical CAS #: 87-86-5 Lock Date: 07/13/95 Cage Range: All Reasons For Removal: 25017 Scheduled Sacrifice Removal Date Range: All Treatment Groups: Include 002 0 PPM Include 010 1000 PPM Include 001 0 PPM Include 009 1000 PPM Page 1 NTP Experiment-Test: 89002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PENTACHLOROPHENOL Date: 10/28/97 Route: DOSED FEED Time: 08:30:52 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | | | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| | A | 0 PPM | 7| 7| 7| 7| 8| 8| 9| 1| 2| 2| | L | | 4| 5| 6| 8| 0| 3| 9| 5| 0| 2| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + | 10 | Basophilic Focus | X X X X | 4 | Inflammation, Chronic | 1 1 1 1 1 1 1 1 1 1 | 10 1.0| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + | 10 | Acinus, Atrophy | 1 | 1 1.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + | 10 | Cardiomyopathy, Chronic | 1 1 | 2 1.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + M + M + + + | 8 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + | 10 | Pars Distalis, Cyst | 2 | 1 2.0| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + | 10 | Inflammation, Chronic Active | 1 1 1 1 1 2 | 6 1.2| __________________________________________________________________________|____________| Ovary | + + + + + + + + + + | 10 | Cyst | 3 | 1 3.0| __________________________________________________________________________|____________| Uterus | + + + + + + + + + + | 10 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 2 NTP Experiment-Test: 89002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PENTACHLOROPHENOL Date: 10/28/97 Route: DOSED FEED Time: 08:30:52 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | | | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| | A | 0 PPM | 7| 7| 7| 7| 8| 8| 9| 1| 2| 2| | L | | 4| 5| 6| 8| 0| 3| 9| 5| 0| 2| | | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Thymus | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + | 10 | Inflammation, Chronic Active | 1 1 1 1 1 1 1 | 7 1.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + | 10 | Inflammation, Chronic Active | 2 3 2 2 | 4 2.3| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 10 | Mineralization | 1 1 1 1 1 1 1 1 1 1 | 10 1.0| Nephropathy, Chronic | 1 1 1 | 3 1.0| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + | 10 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 3 NTP Experiment-Test: 89002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PENTACHLOROPHENOL Date: 10/28/97 Route: DOSED FEED Time: 08:30:52 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | | | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| | A | 1000 PPM | 8| 8| 9| 9| 1| 2| 2| 2| 2| 3| | L | | 6| 9| 0| 2| 4| 4| 5| 7| 9| 4| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + | 10 | Hepatodiaphragmatic Nodule | X X X | 3 | Inflammation, Chronic | 1 1 1 1 1 1 1 1 1 1 | 10 1.0| Centrilobular, Hypertrophy | 1 1 | 2 1.0| Hepatocyte, Necrosis | 1 1 1 | 3 1.0| Hepatocyte, Centrilobular, | | | Hypertrophy | 2 1 2 1 1 2 | 6 1.5| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + | 10 | Cardiomyopathy, Chronic | 1 | 1 1.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Parathyroid Gland | + M + + + M + + + + | 8 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + | 10 | Inflammation, Chronic Active | 1 1 | 2 1.0| __________________________________________________________________________|____________| Ovary | + + + + + + + + + + | 10 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 4 NTP Experiment-Test: 89002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PENTACHLOROPHENOL Date: 10/28/97 Route: DOSED FEED Time: 08:30:52 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | | | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| | A | 1000 PPM | 8| 8| 9| 9| 1| 2| 2| 2| 2| 3| | L | | 6| 9| 0| 2| 4| 4| 5| 7| 9| 4| | | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | Cyst | 3 2 | 2 2.5| __________________________________________________________________________|____________| Uterus | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Thymus | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + | 10 | Inflammation, Chronic Active | 1 1 1 1 1 | 5 1.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + | 10 | Inflammation, Chronic Active | 2 | 1 2.0| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 10 | Mineralization | 1 1 1 1 1 1 1 1 1 1 | 10 1.0| Nephropathy, Chronic | 1 1 1 | 3 1.0| Renal Tubule, Pigmentation | 1 1 1 1 1 1 1 1 1 1 | 10 1.0| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + | 10 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 5 NTP Experiment-Test: 89002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PENTACHLOROPHENOL Date: 10/28/97 Route: DOSED FEED Time: 08:30:52 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | | | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 0 PPM | 1| 1| 2| 3| 3| 3| 4| 4| 5| 5| | L | | 1| 3| 6| 3| 4| 9| 7| 9| 2| 7| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + | 10 | Basophilic Focus | X | 1 | Hepatodiaphragmatic Nodule | X | 1 | Inflammation, Chronic | 1 1 1 1 1 1 1 | 7 1.0| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + | 10 | Acinus, Atrophy | 2 1 | 2 1.5| Acinus, Inflammation, Chronic Active | 2 2 | 2 2.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + | 10 | Cardiomyopathy, Chronic | 2 2 1 2 2 2 2 1 2 | 9 1.8| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Parathyroid Gland | M M M M M M + M + + | 3 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + | 10 | Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 2 1 | 10 1.1| __________________________________________________________________________|____________| Prostate | + + + + + + + + + + | 10 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 6 NTP Experiment-Test: 89002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PENTACHLOROPHENOL Date: 10/28/97 Route: DOSED FEED Time: 08:30:52 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | | | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 0 PPM | 1| 1| 2| 3| 3| 3| 4| 4| 5| 5| | L | | 1| 3| 6| 3| 4| 9| 7| 9| 2| 7| | | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | Inflammation, Chronic Active | 1 1 1 2 1 | 5 1.2| __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Thymus | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + | 10 | Inflammation, Chronic Active | 1 1 1 1 1 1 1 | 7 1.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + | 10 | Fungus | X | 1 | Inflammation, Chronic Active | 3 2 2 2 1 1 | 6 1.8| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 10 | Mineralization | 1 1 1 1 1 1 1 1 | 8 1.0| Nephropathy, Chronic | 1 1 1 1 2 1 1 1 1 1 | 10 1.1| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + | 10 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 7 NTP Experiment-Test: 89002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PENTACHLOROPHENOL Date: 10/28/97 Route: DOSED FEED Time: 08:30:52 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | | | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A | 1000 PPM | 2| 3| 4| 4| 4| 4| 4| 4| 5| 6| | L | | 9| 5| 1| 4| 6| 7| 8| 9| 8| 8| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + | 10 | Basophilic Focus | X | 1 | Inflammation, Chronic | 1 1 1 1 1 | 5 1.0| Artery, Inflammation, Chronic | 1 1 | 2 1.0| Bile Duct, Hyperplasia | 1 1 | 2 1.0| Centrilobular, Hypertrophy | 1 1 1 | 3 1.0| Hepatocyte, Hypertrophy | 1 | 1 1.0| Hepatocyte, Vacuolization Cytoplasmic| 2 1 2 1 1 1 1 1 | 8 1.3| Hepatocyte, Centrilobular, | | | Hypertrophy | 1 2 2 1 2 2 | 6 1.7| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + | 10 | Cardiomyopathy, Chronic | 2 2 1 2 1 1 2 1 1 1 | 10 1.4| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + M + + + + | 9 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + | 10 | Pars Distalis, Hyperplasia | 2 | 1 2.0| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 8 NTP Experiment-Test: 89002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PENTACHLOROPHENOL Date: 10/28/97 Route: DOSED FEED Time: 08:30:52 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | | | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A | 1000 PPM | 2| 3| 4| 4| 4| 4| 4| 4| 5| 6| | L | | 9| 5| 1| 4| 6| 7| 8| 9| 8| 8| | | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + | 10 | Atrophy | 3 | 1 3.0| Inflammation, Chronic Active | 2 | 1 2.0| __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + | 10 | Inflammation, Chronic Active | 2 2 1 1 1 2 1 2 2 1 | 10 1.5| __________________________________________________________________________|____________| Prostate | + + + + + + + + + + | 10 | Inflammation, Chronic Active | 2 2 1 1 1 2 1 | 7 1.4| __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + | 10 | Mineralization | 3 | 1 3.0| Necrosis | 4 | 1 4.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Thymus | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + M + + + + + + + | 9 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + | 10 | Inflammation, Chronic Active | 1 1 2 1 1 1 | 6 1.2| __________________________________________________________________________|____________| Nose | + + + + + + + + + + | 10 | Fungus | X | 1 | Inflammation, Chronic Active | 3 | 1 3.0| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | None | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 9 NTP Experiment-Test: 89002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PENTACHLOROPHENOL Date: 10/28/97 Route: DOSED FEED Time: 08:30:52 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | | | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A | 1000 PPM | 2| 3| 4| 4| 4| 4| 4| 4| 5| 6| | L | | 9| 5| 1| 4| 6| 7| 8| 9| 8| 8| | | __________________________________________________________________________________________________________________________________ URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 10 | Mineralization | 1 1 1 1 1 1 1 1 1 | 9 1.0| Nephropathy, Chronic | 1 1 1 1 1 1 1 1 1 | 9 1.0| Renal Tubule, Pigmentation | 2 2 2 2 2 2 2 2 2 2 | 10 2.0| Transitional Epithelium, Hyperplasia | 1 | 1 1.0| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + | 10 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 10 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------
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